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08.08.2023 | Original Article

Inflammatory human leucocyte antigen genotypes are not a risk factor in chronic subdural hematoma development

verfasst von: Thorbjørn Søren Rønn Jensen, Kåre Fugleholm, Claus Thorn Ekstrøm, Helle Bruunsgaard

Erschienen in: Acta Neurochirurgica | Ausgabe 9/2023

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Abstract

Background

Chronic subdural hematoma (CSDH) pathophysiology has undergone a paradigm shift from being regarded as solely traumatic to be driven mainly by inflammation. Human leucocyte antigen (HLA) is a gene complex involved in antigen processing and presentation to T lymphocytes, thereby mediating the adaptive immune responses. As specific HLA profiles are associated with inflammatory diseases, patients with a specific HLA profile may have a lower threshold for subdural inflammation, and therefore are predisposed for CSDH development.
We hypothesized that (1) CSDH patients have a specific HLA profile compared to a Danish background population, and (2) patients with recurrent CSDH have a specific HLA profile compared to CSDH patients without recurrent CSDH.

Methods

Three specific HLA class II haplotypes known to drive inflammatory-mediated diseases were determined in 68 patients with CSDH. The distribution of these three haplotypes in our CSDH population was compared to a Danish population of blood donors using Monte Carlo Pearson’s chi-square test. Furthermore, the distribution of the haplotypes was compared between CSDH patients with and without recurrent CSDH.

Results

We found no significant association between either of the haplotypes and the risk of CSDH, and neither of the haplotypes were associated with increased risk of CSDH recurrence.

Conclusion

This study did not show an association between selected HLA class II haplotypes and the risk of CSDH or recurrence of CSDH compared with a healthy background population.
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Metadaten
Titel
Inflammatory human leucocyte antigen genotypes are not a risk factor in chronic subdural hematoma development
verfasst von
Thorbjørn Søren Rønn Jensen
Kåre Fugleholm
Claus Thorn Ekstrøm
Helle Bruunsgaard
Publikationsdatum
08.08.2023
Verlag
Springer Vienna
Erschienen in
Acta Neurochirurgica / Ausgabe 9/2023
Print ISSN: 0001-6268
Elektronische ISSN: 0942-0940
DOI
https://doi.org/10.1007/s00701-023-05745-w

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