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Journal of Clinical Immunology

Erschienen in:

01.05.2008

Inflammatory Manifestations in Chronic Granulomatous Disease (CGD)

verfasst von: S. D. Rosenzweig

Erschienen in: Journal of Clinical Immunology | Sonderheft 1/2008

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Abstract

Chronic granulomatous disease (CGD) is a genetically heterogeneous disease characterized by recurrent life-threatening infections with bacteria and fungi as well as dysregulated inflammatory mechanisms. CGD is caused by defects in the NADPH oxidase, the enzyme complex responsible for generation of superoxide and other reactive oxygen species (ROS) in phagocytic cells. In this review we will focus our attention on those particular inflammatory manifestations associated with CGD, their frequencies and the underlying immunologic mechanisms favoring it occurrence.

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Titel: Inflammatory Manifestations in Chronic Granulomatous Disease (CGD)
verfasst von: S. D. Rosenzweig
Publikationsdatum: 01.05.2008
Verlag: Springer US
Erschienen in: Journal of Clinical Immunology / Ausgabe Sonderheft 1/2008
Print ISSN: 0271-9142
Elektronische ISSN: 1573-2592
DOI: https://doi.org/10.1007/s10875-007-9160-5

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Inflammatory Manifestations in Chronic Granulomatous Disease (CGD)

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