The online version of this article (doi:10.1186/1752-1947-8-411) contains supplementary material, which is available to authorized users.
The authors declare that they have no competing interests.
MT drafted the manuscript and performed histopathological and immunohistochemical analysis of the tumour. NB and BK provided the clinical information for the manuscript. AWHB revised the manuscript, approved the histopathological diagnosis of the tumour, and took the photomicrographs. All authors read and approved the final manuscript.
Inflammatory myofibroblastic tumour arising in the adrenal gland is exceptional. As far as we are aware, there have been only three previous reports in the literature. We report a fourth case.
A 29-year-old Caucasian man presented with upper quadrant pain due to a 15cm heterogenous adrenal mass that displaced his liver. He underwent an open right adrenalectomy. Histopathological examination showed the mass to be an inflammatory myofibroblastic tumour, a histologically distinctive lesion composed of myofibroblasts, plasma cells, lymphocytes and histiocytes. Ten months later he is well with no sign of recurrence.
The lesion was indistinguishable on imaging from an adrenal cortical tumour. Surgical treatment is the same but inflammatory myofibroblastic tumour carries a favourable prognosis.
Authors’ original file for figure 113256_2014_3060_MOESM1_ESM.tif
Authors’ original file for figure 213256_2014_3060_MOESM2_ESM.tif
Authors’ original file for figure 313256_2014_3060_MOESM3_ESM.tif
Authors’ original file for figure 413256_2014_3060_MOESM4_ESM.tif
Authors’ original file for figure 513256_2014_3060_MOESM5_ESM.tif
Luo LK, Shen HF, Zhou SY, Li JM, Xu WX: Inflammatory myofibroblastic tumour of adrenal. Zhonghua Bing Li Xue Za Zhi. 2006, 35 (4): 252-253. PubMed
Wang T-Y, Chou J-W, Shih Y-S: Inflammatory myofibroblastic tumour mimicking adrenal incidentaloma. Inter Med. 2011, 50: 165-166. 10.2169/internalmedicine.50.4545. CrossRef
Chawla A, Hameed Z, Mishra D, Monappa V: Adrenal inflammatory myofibroblastic tumour. BMJ Case Rep. 2013,: doi:10.1136/bcr-2013-010122
Brunn H: Two interesting benign lung tumours of contradictory histopathology: remarks on the necessity for maintaining the chest tumour registry. J Thorac Cardiovasc Surg. 1939, 9: 119-131.
Umiker WO, Iverson L: Postinflammatory ‘tumours’ of the lung: report of four cases simulating xanthoma, fibroma, or plasma cell tumour. J Thorac Cardiovasc Surg. 1954, 28: 55-63.
Marino-Enriquez A, Wang WL, Roy A, Lopez-Terrada D, Lazar AJ, Fletcher CD, Coffin CM, Hornick JL: Epithelioid inflammatory myofibroblastic sarcoma; an aggressive intra-abdominal variant of inflammatory myofibroblastic tumour with nuclear membrane or perinuclear ALK. Am J Surg Pathol. 2011, 35: 135-144. 10.1097/PAS.0b013e318200cfd5. CrossRefPubMed
- Inflammatory myofibroblastic tumour arising in the adrenal gland: a case report
Alan WH Bates
- BioMed Central