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Rheumatology International

Erschienen in:

01.08.2009 | Original Article

Inflammatory response in patients with active and inactive osteoarthritis

verfasst von: Antoaneta Toncheva, Mimi Remichkova, Krassimira Ikonomova, Petya Dimitrova, Nina Ivanovska

Erschienen in: Rheumatology International | Ausgabe 10/2009

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Abstract

In the present study, we have investigated comparatively the inflammatory response of patients with active and inactive osteoarthritis. The sera from 31 healthy individuals, 37 patients with active OA, and 19 patients with inactive OA were assayed for TNF-α, IL-6, sRANKL, RANTES, and MRP8 using ELISA in order to evaluate their potential as markers of disease activity. Also, the spontaneous and LSP-induced release of TNF-α and IL-6 by peripheral blood neutrophils was determined. The activation of OA is associated with elevated TNF-α, IL-6, and RANTES serum levels while sRANKL and MRP8 appeared to be increased in both active and inactive OA. The neutrophil spontaneous and up-regulated by LPS cytokine release can contribute to the exacerbation of OA.

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Titel: Inflammatory response in patients with active and inactive osteoarthritis
verfasst von: Antoaneta Toncheva
Mimi Remichkova
Krassimira Ikonomova
Petya Dimitrova
Nina Ivanovska
Publikationsdatum: 01.08.2009
Verlag: Springer-Verlag
Erschienen in: Rheumatology International / Ausgabe 10/2009
Print ISSN: 0172-8172
Elektronische ISSN: 1437-160X
DOI: https://doi.org/10.1007/s00296-009-0864-0

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