Ausgabe 11/2025
Inhalt (41 Artikel)
Curcumin: multifaceted biological actions and therapeutic implications—a narrative review
- Review
Behnam Ghorbani-nejad, Matin Baghani, Sajad Amiri, Nasim Agaei Delche, Mohammad Hossein Darijani, Motahareh Soltani, Alireza Nezami, Milad Rahimzadegan
Biochemical investigations, in silico study and targeted delivery aspects of plant phytosterols: β-sitosterol
- Review
Tejaswini V. Jagtap, Ashwini R. Madgulkar, Mangesh R. Bhalekar
Modulating inflammation and oxidative stress in rheumatoid arthritis: a systematic review of nutraceutical interventions
- Open Access
- Review
Camila Leiva-Castro, Ana M. Múnera-Rodríguez, Gádor Torres-Joya, Francisca Palomares-Jerez, Soledad López-Enríquez
Therapeutic potential of purpurin, a natural anthraquinone dye, in neuroprotection and neurological disorders
- Open Access
- Review
Aya M. Mustafa, Ghadir A. Sayed, Shymaa Hatem, Roxane Abdel-Gawad Moussa, Dina M. Hal, Mahmoud A. Mansour, Mohamed S. Abd El Hafeez
Asperuloside: an emerging therapeutic candidate for Parkinson’s disease through molecular mechanistic insights
- Review
Shiv Kumar Kushawaha, Kanika Vashisht, Himanshu Kumar, Mahendra Singh Ashawat, Ashish Baldi
Innovative polymer-based therapeutics targeting inflammation for responsive drug delivery in disease treatment
- Review
Km Lipsi, Milind Pande
Nrf2 signaling in bone health: unlocking new avenues for osteoporosis management
- Review
Mitali P. Lavhale, Satish K. Mandlik, Vaibhav M. Shinde, Deepa S. Mandlik
Exploring herbal synergies in the management of rheumatoid arthritis: a multifaceted approach to inflammation and joint health
- Review
Shikhar Verma, Mitali Panchpuri, Vagish Dwibedi, Santosh Kumar Rath, Arti Devi
Neurodegeneration and aging: pathophysiology, diagnosis, and therapeutic targets
- Review
Abhay Thakur, Rahul Sharma, Rohit Sharma, Anjana Devi
Inflammation and immune biomarkers: new frontiers in understanding and managing diabetes complications
- Review
Polu Picheswara Rao, Shubham Mishra, Jaya Gupta, Manish Vyas, Malakapogu Ravindra Babu
URAT1 and GLUT9 as drug targets in gout: progress in transporter-directed therapies and delivery technologies
- Review
Soumya Mishra, Ranjit K. Harwansh, Rupa Mazumder
Targeting the senescence-associated secretory phenotype to modify osteoarthritis in aging
- Review
Muhammad Afzal, M. M. Rekha, Samir Sahoo, Surya Nath Pandey, Chandana Maji, Kavita Goyal, Haider Ali, Sachin Kumar Singh, Gaurav Gupta, Md Sadique Hussain
Targeting the NLRP3 inflammasome with natural products for ischemia–reperfusion injury across organs: mechanisms, structure–activity relationships, and delivery innovations
- Review
Rajnish Kumar, Archna Singh, Shrishti Tripathi, Salahuddin, Mohd. Mustaqeem Abdullah
Enterogenic dementia: defining the gut–brain axis and the role of inflammatory bowel disease in cognitive impairment
- Review
Faisal Alshammari, Hayder M. Al-Kuraishy, Mustafa M. Shokr, Marios Papadakis, Athanasios Alexiou, Gaber El-Saber Batiha
Chloroquine protects against mesenteric ischemia: insights into the role of nitrergic and opioidergic systems
- Original Article
Seyed Amir Mahdi Emami, Amirabbas Mohammadi Hamaneh, Moein Ghasemi, Alireza Abdollahi, Kimiya Jouyban, Razieh Mohammad Jafari, Amir Hossein Abdolghaffari, Ahmad Reza Dehpour
Quinic acid alleviates inflammatory responses and oxidative stress in Freund’s complete adjuvant-induced arthritic rat model and associated risk factors of atherosclerosis
- Open Access
- Original Article
Iqra, Ali Sharif, Bushra Akhtar, Chuxiao Shao, Shuanghu Wang, Ayesha Younas
Impact of Psidium guajava bark extract on inflammatory biomarkers in Wistar rat models of inflammation
- Original Article
Eleazar Chukwuemeka Anorue, Amaechi L. Ogara, Parker Elijah Joshua, Divine Godswill Ibekwe, Anthony Ikechukwu Igbokwe
Nanoencapsulated Syzygium aromaticum oil alleviates acetic acid-induced ulcerative colitis in rats by influencing critical redox, NF-κB/iNOS, and Keap1/Nrf2/HO-1 signaling pathways
- Open Access
- Original Article
Gehad E. Elshopakey, Shaymaa Rezk, Ahmed Ateya, Tarek A. Elkhooly, Alaa A. Omar, Ali El-Far, Ekramy M. Elmorsy, Hala Magdy Anwer, Mona M. Elghareeb
Salvia argentea L. extract inhibits the production of NO, and pro-inflammatory cytokines (IL-1β, IL-6, and TNF-α), alleviates the inflammatory response of LPS-induced macrophages cells, and reduces the CRP level on carrageenan-induced paw edema
- Original Article
Almonther Alhamedi, Tugce Demiroz Akbulut, Sura Baykan, Barış Gümüştaş, Ebru Sanci, Karrar Ali Mohammed Hasan Alsakini, Ayşe Nalbantsoy, Aylin Buhur, Altuğ Yavasoğlu, N. Ülkü Karabay Yavasoğlu
Genetic changes in regulatory immune cells induced by pramipexole and rotigotine: implications for the treatment of Parkinson’s disease
- Original Article
Diana Denisse Álvarez-Luquín, Adrián Guevara-Salinas, Edgar Sevilla-Reyes, Jorge Rosas-García, Miriam Bravo-Martinez, Gloria Erandi Pérez-Figueroa, Vera Teresa Vega-Angeles, Dafne Díaz-Rivera, Carlos Castellanos-Barba, Laura Adalid-Peralta
Boswellic acids as an adjunct therapy in Parkinson’s disease: a double-blind clinical trial investigating on its effects on motor symptoms and inflammatory markers
- Original Article
Somayyeh Shateri, Seyyed Hossein Khatami, Sajad Ehtiati, Mohammad Reza Talebzadeh, Sadegh Nikakhtar, Monir Hassani Parvar, Seyedeh Ozra Hosseini, Gholamali Shahidi, Amir Hossein Habibi, Farzaneh Salmani, Fatemeh Namvarjah, Ali Riazi, Abbas Tafakhori, Saeed Karima
L-carnitine as a novel approach for pain and inflammation relief in rheumatoid arthritis
- Open Access
- Original Article
Abdallah A. Eldisouky, Sahar K. Hegazy, Salwa Elmorsy Abd Elghany
Adjunctive zinc supplementation with methotrexate improves therapeutic outcomes in an animal model of arthritis
- Original Article
Mohammad Hasan, Manu Sharma, Abul Vafa, Mairaj Ahmed Ansari, Shakir Ali, Haider A. Khan
Clinical study evaluating the gastroprotective effect of carvedilol in patients with ischemic heart disease on aspirin therapy
- Open Access
- Original Article
Sarah M. Elkablawy, Aliaa E. Shaban, Tarek M. Mostafa
Fabrication of bergapten loaded microneedle patch and assessment of its anti-arthritic potential against complete Freund’s adjuvant induced arthritis in Wistar rat
- Original Article
Qadeer Ahmad, Ammara Saleem, Zulcaif Ahmad, Muhammad Furqan Akhtar
Kaempferol prevents Nrf2 from ubiquitin-mediated proteolysis to mitigate both NLRP3 inflammation and oxidative stress: implications for alleviating DSS-induced colitis in mice
- Original Article
Wentian Hua, Minrui Li, Ziwei Yan, Yingchao Wang, Xiang Zhou, Zhiwen Fu, Yi Wang, Shujing Zhang, Jing Qian
Resveratrol supplementation improves functional performance in knee osteoarthritis by upregulating sirtuin 1: a randomized study
- Original Article
Asima Karim, Haroon Ahmed Khan, Firdos Ahmad, Rizwan Qaisar
The potential protective effect of Empagliflozin against Cisplatin-induced ovarian damage via upregulation of SIRT1/Nrf2 and amelioration ER Stress
- Open Access
- Original Article
Magda E. El-Sayad, Sally E. Abu-Risha, Sarah S. El-sisi, Hanaa A. Ibrahim
Diallyl disulfide attenuates DSS-induced colonic fibrosis in mice by modulating gut microbiota and Nrf2 signaling
- Original Article
Shuangshuang Hai, Yan Chen, Meiyan Zhang, Weixin Liu, Xiaohong Sun
Unveiling the antioxidant and anti-inflammatory potentials of Gomphostigma virgatum and analyzing its phytochemical profile
- Original Article
Emmanuel Mfotie Njoya, Gaetan T. Tabakam, Chika I. Chukwuma, Tshepiso J. Makhafola
Efficacy and safety of cyclosporine in colitis: An updated meta-analysis of randomized control trials (1998 to 2024)
- Original Article
Aqsa Mehreen, Faiza Batool, Uzma Azeem Awan, Shaista Aslam, Adnan Haider, Muneeb Ullah, Jin-Wook Yoo, Rida Fatima Saeed, Muhammad Naeem
Sodium hydrogen sulfide restores H2S-synthesizing and degrading enzymes to alleviate glial activation after traumatic brain injury in male mice
- Original Article
Farheen Nasir, Priyanka Yadav, Thamil Mani Sivanandam
Pretreatment with probiotics (Bacillus safensis NMCC-189 and Bacillus clausii) prevents epileptogenesis in mice via modulation of BBB integrity, oxidative stress, and neurotransmitter balance
- Original Article
Maryam Khan Sherwani, Jehan Zeb Khan, Shakira Ghazanfar, Fahim Hilal, Rimsha Noor, Muhammad Khalid Tipu
Anti-inflammatory potential of telmisartan compared to other antihypertensives: secondary outcomes from a randomized trial
- Original Article
Simi Bridjit Gomaz, Jaykaran Charan, Amal Mohandas, Pravesh Aggarwal, Deepak Kumar, Dharmveer Yadav, Ravindra Shukla, Sneha Ambwani, Rimple Jeet Kaur
Silybum marianum seeds mitigate pro-inflammatory functions of human neutrophils and alleviate ulcerative colitis in rats
- Original Article
Ahmed Kouki, Riadh Marrouchi, Abdelaziz Souli, Salwa Bouabdallah, Wafa Ferjani, Pham My-Chan Dang, Amadou Dicko, Jamel El-Benna, Mossadok Ben-Attia
Dual evaluation of Citrullus colocynthis fruit extract for anti-rheumatic activity: integrating in silico docking and in vivo murine RA model analysis
- Original Article
Jawad Ashfaq, Muti-Ur-Rehman Khan, Asim Aslam, Arfan Ahmad, Adeel Sattar, Waqas Ahmad
Phlomoides molucelloides (Bunge) Salmaki essential oil: a traditional remedy revitalized for modern antimicrobial challenges
- Original Article
Mansureh Ghavam, Gianluigi Bacchetta, Ines Castangia, Maria Letizia Manca
Evaluating pomegranate seed oil for potential topical applications: safety, anti-inflammatory activity and wound healing in skin cell models
- Original Article
Eduardo M. Costa, Manuela Machado, Manuela Pintado, Sara Silva
Trypsin inhibitor isolated from the seeds of Inga laurina (sw.) Willd decreased inflammatory and nociceptive responses in mice
- Original Article
Iluska Senna Bonfá, Dalila dos Santos Lencina, Jéssica de Araújo Isaías Muller, Paloma Kênia de Moraes Berenguel Lossavaro, Mila Marluce Lima Fernandes, Joyce dos Santos Lencina, Gabriel Silvino de Oliveira Venâncio, Kamylla Fernanda Souza de Souza, Julia Lopes Ribeiro Fredo, Maria Inês Lenz Souza, Saulo Euclides Silva Filho, Edgar Julian Paredes Gamero, Ana Cristina Jocobowski, Maria Ligia Rodrigues Macedo, Mônica Cristina Toffoli Kadri
Ozone therapy for temporomandibular joint osteoarthritis: a comment on the mechanistic insights and clinical translation
- Commentary
DuJiang Yang, Jian Wu, Junjie Chen, Shuang Wang, Gaowen Gong, GuoYou Wang
