Ausgabe 8/2025
Inhalt (41 Artikel)
Phytochemical modulation of mTOR signaling: emerging nanotechnology-driven therapeutics for rheumatoid arthritis management
- Review
Deepa Mandlik, Prapti Adgaonkar, Satish Mandlik
Advancing osteoarthritis management: integrating new insights and addressing persistent roadblocks
- Review
Aditi Kaushik, Vrinda Gupta, Manish Kaushik, Amardeep Ankalgi, M. S. Ashawat, C. P. S. Verma, Deewakar Baral
Neuroprotective effects of rutin in ischemic stroke: a review
- Review
Ali Mohammad Pourbagher-Shahri, Fatemeh Forouzanfar, Ehsan Saburi, Hanie Mahaki
Berberine as a natural immunomodulator of B lymphocytes
- Review
Saeed Mohammadian Haftcheshmeh, Maryam Musavi, Shadi Lotfi, Anvar Soleimani, Masoumeh Dodangeh, Asadollah Mohammadi, Amir Abbas Momtazi-Borojeni
New insights on pharmacological potential of montelukast: a comprehensive review
- Review
Karan Goel, Dhirendra Singh, Rajat Goyal, Seema Bansal, Sukhbir Singh, Neelam Sharma, Sumeet Gupta
A systematic review of the role of interleukin inhibitors in lichen planus: therapeutic and paradoxical effects
- Review
Amirhossein Heidari, Fatemeh Fathabadi, Kimia Ghanavati, Asma Rasouli, Sanaz Soleimani, Nazila Heidari
Psoriatic arthritis in transition: cytokine signaling, immune dysregulation, and therapeutic innovation
- Review
Sanjana Sahu, Parag Jain, Rohitas Deshmukh, Pradeep Kumar Samal, Trilochan Satapathy, Ajazuddin
Immunopharmacology of senescence: targeting the senescence-associated secretory phenotype (SASP)—a mechanism-based review
- Review
Poonam Sahu, Trilochan Satapathy
Asperuloside as a promising multi-target agent for Alzheimer’s disease: molecular mechanisms and therapeutic perspectives
- Review
Kanika Vashisht, Himanshu Kumar, Amardeep Ankalgi, Mahendra Singh Ashawat, Rimpi, Shiv Kumar Kushawaha, Ashish Baldi
Traumatic Brian Injury (TBI) unraveled: molecular disruptions and therapeutic avenues
- Review
Nisha Kumari, Kajal Bagri, Shilpa Kumari, Rahul Deshmukh
Phytotherapeutic insights into hyperuricemia: a mechanistic and clinical perspective
- Review
Kanika Kaushal, Nishant Goutam, Abhishashi Sharma, Shivani
From the Amazon to modern pharmacology: medicinal plants as metabolic and cardiovascular modulators in cardiodiabesity
- Review
Bruno Portela Dias, Henrick Vinícius Prado Dantas, João de Barros Neto, Thiago Afonso Carvalho Celestino Teixeira, Heitor Ribeiro da Silva, Erdi Can Aytar, José Carlos Tavares Carvalho
Semaphorin-3A in autoimmune rheumatic diseases: immunological and pathological aspects
- Review
Ramin Lotfi, Hoda Rahmani, Alireza Nasirifar
Targeting JAK/STAT signaling pathway by curcumin: implications for spinal cord injury neuroprotection
- Review
Abroumand Gholami Arman, Fatemeh Tahmasebi, Hossein Haghir, Hamideh Babaloo
Deciphering the iridoids' boundaries: from soil ecology to anti-inflammatory medicines
- Review
M. V. N. L. Chaitanya, Hemanth Kumar Manikyam, Neerugatti Dora Babu, Sachin Kumar Singh, Avijit Mazumder, Sanjesh Kumar, Ramanjireddy Tatiparthi, T. Prabha, Sakshi Sharma
Insights into ion channels to identify drug target for neuropathic pain management
- Review
Shiwani Sharma, Priyanka Rana, Neelima Dhingra, Tanzeer Kaur
Chemokine receptor type-5: a key regulator of immunity, disease pathogenesis, and emerging therapeutic target
- Review
Vaishali Bambal, Priyanka Kodihalli Basavaraj, Kenchappa Vanaja
Anti-arthritic and immunomodulatory effects of geniposide: a systematic review and meta-analysis of preclinical studies
- Review
Muhammad Muzammil Nazir, Asma Ashraf, Muhammad Mubashir Nazir, Mohammad Rameez Hashmi
Modulating endoplasmic reticulum stress and NLRP3 inflammasome in polycystic ovary syndrome: a review of natural and synthetic compounds
- Review
Arfah Siddiqua, Abdul Malik, Urooj Iqbal
Polyphenolic protection: the role of mangiferin in mitigating neurodegeneration and neuroinflammation
- Open Access
- Review
Aya M. Mustafa, Ghadir A. Bastawesy, Shymaa Hatem, Roxane Abdel-Gawad Moussa, Dina M. Hal, Mariam H. Fawzy, Mahmoud A. Mansour, Mohamed S. Abd El Hafeez
Therapeutic potential of melatonin-induced mitophagy in the pathogenesis of Alzheimer’s disease
- Review
Pouya Goleij, Mohammad Amin Khazeei Tabari, Mohadeseh Poudineh, Pantea Majma Sanaye, Haroon Khan, Alan Prem Kumar, Danaé S Larsen, Maria Daglia
Antidiabetic drugs in Parkinson’s disease: a comprehensive meta-analysis on efficacy and safety with trial sequential analysis and GRADE evaluation
- Open Access
- Review
Amr M. Abou Elezz, Kareem Khalefa, Ahmed Farid Gadelmawla, Youssef A. Khattab, Mohamed Abo Zeid
Recent advancement in molecular pathways and receptor targeting using natural products for wound healing activity
- Review
Ankita Sinha, Parag Jain, Ajazuddin
Associations of genetic proxies for non-steroidal anti-inflammatory drugs with increased kidney stone risk: a Mendelian randomization study
- Open Access
- Original Article
Junfa Liu, Kaiyi Dong, Gang Qin, Chunyan Ye, Jinghan Wu, E. Wang, Zhitao Dong
Therapeutic efficacy of celastrol in experimental polyarthritis: insights from a meta-analysis of in vivo studies
- Original Article
Muhammad Muzammil Nazir, Iqra Farzeen, Asma Ashraf
Is dolichol pathway dysfunction a significant factor in Alzheimer’s disease?
- Open Access
- Original Article
John V. Schloss
The use of statins can reduce the risk of osteoarthritis and osteoporosis
- Original Article
Xin Zeng, Fei Luo, Xiao-dong Wang, Wan-jun Cao, Yong-jie Chen, Qiang Su
Safety profile of glucokinase activator AZD1656: systematic review and meta-analysis of 23 randomised trials in diabetic and healthy volunteers with relevance to immunomodulatory therapy
- Open Access
- Original Article
Mohamed M. Elsayed, Mohamed M. Abdalla
Stabilizing effect of green tea extract and epigallocatechin-3-gallate (EGCG) on mast cell : an in vivo study
- Original Article
Md. Mominul Islam, Nadiah Syafiqah Nor Azman, Sreemoy kanti Das, Mohd Gousuddin, Md. Abu Hasan Rasel, Md. Robiul Islam, Nadia Izbeta Bini
Antioxidative and anti-inflammatory effects of Carvacrol against polycystic ovary syndrome associated complications using high fat diet and Letrozole challenged rat model: a multidisciplinary study cascading in vivo, in vitro, in silico and network pharmacology approaches
- Original Article
Arfah Siddiqua, Abdul Malik, Urooj Iqbal, Nabeela Tabassum Sial, Malik Hassan Mehmood, Muhammad Fayyaz ur Rehman
Intact glycoconjugates from Taenia crassiceps excreted/secreted products ameliorate chemically induced colitis by modulating inflammation and strengthening adherens junctions
- Open Access
- Original Article
Yadira Ledesma-Soto, Ilse Chávez-Soto, Marissa Calderón-Torres, Andrea Monserrat Rodríguez-Lozoya, Jonadab E. Olguin, Luis B. Hernández-Portilla, César M. Flores-Ortíz, Fernando Candanedo, Miriam Rodriguez-Sosa, Sonia E. Hernández-Navia, Luis I. Terrazas
Neuroinflammation and metabolic dysregulation as predictors of cognitive impairment, depression, and quality of life in type 2 diabetes mellitus patients on SGLT2 inhibitors and sulfonylureas
- Original Article
Haya Majid, Sajad Ul Islam, Sunil Kohli, Nidhi
A novel in vivo adjuvant activity of hydrocarbon isolated from Hippophae rhamnoides
- Original Article
Himanshi Tanwar, Shruti Shukla, Lilly Ganju
Anti-inflammatory and gastroprotective effects of Fagonia bruguieri var. laxa (Zygophyllaceae) via attenuating biochemical alterations and cellular damage in experimental animals
- Original Article
Faraza Javaid, Humaira Gul, Farhan Mukhtar, Salman Farsi, Sana Ghafoor, Hafiza Maida Arshad
Synaptamide regulates astroglial functional activity after cerebral cortex injury
- Original Article
Igor Manzhulo, Anastasia Egoraeva, Darya Ivashkevich, Olga Manzhulo, Arina Ponomarenko
Fenchone attenuates CD68-dependent 7-ketocholesterol accumulation, cholesterol dyshomeostasis and inflammatory responses via modulation of macrophage polarization
- Original Article
Sangeetha Ravi, Livya Catherene Martin, Manikandan Kumaresan, Jaya Suriya Mani, Beulaja Manikandan, Manikandan Ramar
Is ibuprofen associated with upper gastrointestinal bleeding? A systematic review and meta-analysis
- Original Article
Konstantinos Gkiouras, Ioannis Myrogiannis, Dimitrios Kouvelas
Exploring the potential of Moringa oleifera seed extract-loaded microemulsion hydrogel in the DNCB-induced atopic dermatitis model
- Original Article
Prakrati Garg, Aaliya Ali, Sewa Singh, Kanika Thakur, Kaisar Raza, Bigul Yogeshver Bhardwaj, Saurabh Kulshrestha, Poonam Negi
Gastroprotective effect of Arabincoside B isolated from Caralluma arabica against ethanol-induced gastric injury via modulating oxidative stress/SP/NK-1R/NF-κB loop
- Open Access
- Short Communication
Dalia E. Ali, Othman S. S. Al-Hawshabi, Sarah A. Abd El-Aal, Eman Sheta, Sherihan Salaheldin Abdelhamid Ibrahim, Amira A. El-Gazar, Essam Abdel-Sattar, Ghada M. Ragab
Effect of N-Acetylcysteine on mortality in COVID-19 patients: A systematic review and meta-analysis of randomized controlled trials
- Short Communication
Chia Siang Kow, Dinesh Sangarran Ramachandram, Syed Shahzad Hasan, Kaeshaelya Thiruchelvam
Concerning BPC-157, a natural pentadecapeptide, that acts as a cytoprotectant and is believed to protect the gastro-intestinal tract (GIT)
- Open Access
- Commentary
Michael Whitehouse
