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01.12.2017 | Review | Ausgabe 1/2017 Open Access

Radiation Oncology 1/2017

Influence of autophagy on the efficacy of radiotherapy

Zeitschrift:
Radiation Oncology > Ausgabe 1/2017
Autoren:
Shing Yau Tam, Vincent Wing Cheung Wu, Helen Ka Wai Law

Abstract

Autophagy is an important catabolic process in which cells digest and recycle their own cytoplasmic contents for maintaining cellular homeostasis. Interestingly, autophagy could play both pro-death and pro-survival roles in influencing the development of cancer via various signal pathways. As radiotherapy is one of the main treatment modalities for cancer, we reviewed the effect of autophagy modulations on radiosensitivity and radiotherapy efficacy in various cancer types. The future development of autophagy modifications for improving radiotherapy efficacy and cancer prognosis will also be discussed.
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