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01.06.2014 | Magnetic Resonance

Influence of Calcium on Choline Measurements by 1H MR Spectroscopy of Thigh Muscles

verfasst von: Pedro A. Gondim Teixeira, Gabriela Hossu, François Kauffmann, Anou Sewonu, Jean-Marc Constans, Alain Blum, Jacques Felblinger

Erschienen in: European Radiology | Ausgabe 6/2014

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Abstract

Objective

To study the effects of calcium on the choline peak measurements with 1H MR spectroscopy.

Material and methods

The thigh muscles of two cadaveric specimens were prospectively evaluated on a 3 T MR unit before and after the injection of calcium carbonate (up to 0.4322 g). The choline peaks of 147 spectra from 10 different anatomic locations were quantitatively evaluated. The influence of the calcium concentration and its disposition with respect to the main magnetic field were considered. B₀ phase maps were used to evaluate field inhomogeneities.

Results

The presence of calcium led to a 43 % underestimation of the choline peak and the choline concentration (p = 0.0002 and 0.0036). The mean choline concentrations before and after CaCO3 injection were 3.53 ± 1.72 mmol/l and 1.58 ± 0.63 mmol/l. The influence of calcium carbonate on the choline peak estimations was proportional to the calcium concentration. There was a significant position-dependent difference in the estimation of the choline peak amplitude (p < 0.0154). Calcium injection led to a measurable increase in field inhomogeneities.

Conclusion

There was a significant underestimation of the choline peak amplitude and concentration in the presence of calcium, which might cause misinterpretations of MR spectra.

Key Points

• The presence of calcium led to significant underestimation of choline measurements.

• The influence of calcium is dependent on its concentration and distribution.

• Quantitative MR spectroscopy of calcified tumours should be interpreted with caution.

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Titel: Influence of Calcium on Choline Measurements by 1H MR Spectroscopy of Thigh Muscles
verfasst von: Pedro A. Gondim Teixeira
Gabriela Hossu
François Kauffmann
Anou Sewonu
Jean-Marc Constans
Alain Blum
Jacques Felblinger
Publikationsdatum: 01.06.2014
Verlag: Springer Berlin Heidelberg
Erschienen in: European Radiology / Ausgabe 6/2014
Print ISSN: 0938-7994
Elektronische ISSN: 1432-1084
DOI: https://doi.org/10.1007/s00330-014-3131-z

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Influence of Calcium on Choline Measurements by 1H MR Spectroscopy of Thigh Muscles

Abstract

Objective

Material and methods

Results

Conclusion

Key Points

Neu im Fachgebiet Radiologie

Fünf Dinge, die im Kindernotfall besser zu unterlassen sind

Wie toxische Männlichkeit der Gesundheit von Männern schadet

Studie bestätigt Potenzial von KI in der Radiologie

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Update Radiologie

Live-Webinar: Aktuelle Leitlinien bei Herz-Kreislauf-Erkrankungen

Springer Medizin

Abstract

Objective

Material and methods

Results

Conclusion

Key Points

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