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29.05.2019 | Original Article

Influence of chronic diseases on the olfactory function in children

verfasst von: Janine Gellrich, Marie-Luise Dabow, Christian Vogelberg, Felix Reschke, Andrea Näke, Maja von der Hagen, Valentin A. Schriever

Erschienen in: European Journal of Pediatrics | Ausgabe 8/2019

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Abstract

The association between smell impairment and chronic diseases has been reported in some studies in adults. Such information is not available for chronic diseases in children. The aim of this study was to examine olfactory function of children with chronic diseases such as diabetes mellitus type 1, hypothyroidism, and bronchial asthma in combination with allergic rhinitis in comparison to healthy controls. The data were obtained from n = 205 participants (104 boys, 101 girls) between the age of 6 and 17 years. Seventy-eight of the participants were healthy controls, n = 43 had diabetes mellitus type 1, n = 50 suffer from allergic rhinitis or bronchial asthma, and 34 presented a reduced function of their thyroid in medical history. All participants underwent olfactory testing including olfactory threshold using “Sniffin’ Sticks” and odor identification using the “U-Sniff” test. In addition, a depression inventory and cognitive testing using the Ravens Progressive Matrices was performed. No significant difference in olfactory function was observed for any of the chronic diseases in children in comparison to healthy controls. Further analysis showed a trend in significance for a subpopulation of children with bronchial asthma and comorbidities performed worse on the olfactory threshold test compared to patients with bronchial asthma without comorbidities. Pediatric patients suffering from chronic diseases scored higher on the depression inventory compared to healthy controls.

Conclusion: In conclusion, this study demonstrates that the influence of chronic diseases (bronchial asthma, diabetes mellitus type 1 and hypothyroidism) on olfactory function in childhood, if any, seems to be insignificant. This is partly in contrast to adult patients. Further research should be conducted in a subgroup of patients with bronchial asthma, allergic rhinitis, and atopic dermatitis or other comorbidities to better understand the association of allergic diathesis and olfactory function and the putative pathogenesis of olfactory dysfunction.

What is known:
• The association between smell impairment and chronic diseases has been reported in some studies in adults.
• Such information is not available for chronic diseases in children.
What is new:
• The influence of chronic diseases (bronchial asthma, diabetes mellitus type 1, and hypothyroidism) on olfactory function in childhood, if any, seems to be insignificant.
• In patients with bronchial asthma and allergic rhinitis, only a subgroup of patients with additional comorbidity (atopic dermatitis) showed a tendency to a reduced sense of smell.

Aj A, Ae M, Me F, Jm C (1995) Allergic rhinitis and olfactory loss. Ann Allergy Asthma Immunol 75:311–316

Altundag A, Cayonu M, Kayabasoglu G, Salihoglu M, Tekeli H, Saglam O, Hummel T (2015) Modified olfactory training in patients with postinfectious olfactory loss. Laryngoscope 125:1763–1766. https://doi.org/10.1002/lary.25245 CrossRefPubMed

Altundag A, Ay SA, Hira S, Salıhoglu M, Baskoy K, Denız F, Tekelı H, Kurt O, Yonem A, Hummel T (2017) Olfactory and gustatory functions in patients with non-complicated type 1 diabetes mellitus. Eur Arch Otorhinolaryngol 274:2621–2627. https://doi.org/10.1007/s00405-017-4497-8 CrossRefPubMed

Armstrong JE, Laing DG, Wilkes FJ, Kainer G (2010) Smell and taste function in children with chronic kidney disease. Pediatr Nephrol Berl Ger 25:1497–1504. https://doi.org/10.1007/s00467-010-1529-7 CrossRef

Beard MD, Mackay-Sim A (1987) Loss of sense of smell in adult, hypothyroid mice. Dev Brain Res 36:181–189. https://doi.org/10.1016/0165-3806(87)90022-8 CrossRef

Brosvic GM, Risser JM, Mackay-Sim A, Doty RL (1996) Odor detection performance in hypothyroid and euthyroid rats. Physiol Behav 59:117–121. https://doi.org/10.1016/0031-9384(95)00145-X CrossRefPubMed

Cowart B, Flynnrodden K, Mcgeady S, Lowry L (1993) Hyposmia in allergic rhinitis. J Allergy Clin Immunol 91:747–751. https://doi.org/10.1016/0091-6749(93)90194-K CrossRef

Croy I, Symmank A, Schellong J, Hummel C, Gerber J, Joraschky P, Hummel T (2014) Olfaction as a marker for depression in humans. J Affect Disord 160:80–86. https://doi.org/10.1016/j.jad.2013.12.026 CrossRef

Deniz F, Ay SA, Salihoglu M, Kurt O, Baskoy K, Altundag A, Tekeli H, Yonem A, Hummel T (2016) Thyroid hormone replacement therapy improves olfaction and taste sensitivity in primary hypothyroid patients: a prospective randomised clinical trial. Exp Clin Endocrinol Diabetes 124:562–567. https://doi.org/10.1055/s-0042-108446 CrossRefPubMed

10.

Doty RL, Mishra A (2001) Olfaction and its alteration by nasal obstruction, rhinitis, and rhinosinusitis. Laryngoscope 111:409–423. https://doi.org/10.1097/00005537-200103000-00008 CrossRefPubMed

11.

Enwere E, Shingo T, Gregg C, Fujikawa H, Ohta S, Weiss S (2004) Aging results in reduced epidermal growth factor receptor signaling, diminished olfactory neurogenesis, and deficits in fine olfactory discrimination. J Neurosci 24:8354–8365. https://doi.org/10.1523/JNEUROSCI.2751-04.2004 CrossRefPubMed

12.

Fischer M, Zopf Y, Elm C, Pechmann G, Hahn EG, Schwab D, Kornhuber J, Thuerauf NJ (2014) Subjective and objective olfactory abnormalities in Crohn’s disease. Chem Senses 39:529–538. https://doi.org/10.1093/chemse/bju022 CrossRefPubMed

13.

Floch J-PL, Lièvre GL, Labroue M, Paul M, Peynegre R, Perlemuter L (1993) Smell dysfunction and related factors in diabetic patients. Diabetes Care 16:934–937. https://doi.org/10.2337/diacare.16.6.934 CrossRefPubMed

14.

Gellrich J, Stetzler C, Oleszkiewicz A, Hummel T, Schriever VA (2017) Olfactory threshold and odor discrimination ability in children – evaluation of a modified “Sniffin’ Sticks” test. Sci Rep 7(1928):1928. https://doi.org/10.1038/s41598-017-01465-1 CrossRefPubMedPubMedCentral

15.

Gouveri E, Katotomichelakis M, Gouveris H, Danielides V, Maltezos E, Papanas N (2014) Olfactory dysfunction in type 2 diabetes mellitus: an additional manifestation of microvascular disease? Angiology 65:869–876. https://doi.org/10.1177/0003319714520956 CrossRefPubMed

16.

Guilemany JM, García-Piñero A, Alobid I, Cardelús S, Centellas S, Bartra J, Valero A, Picado C, Mullol J (2009) Persistent allergic rhinitis has a moderate impact on the sense of smell, depending on both nasal congestion and inflammation. Laryngoscope 119:233–238. https://doi.org/10.1002/lary.20075 CrossRef

17.

Guss J, Doghramji L, Reger C, Chiu AG (2009) Olfactory dysfunction in allergic rhinitis. ORL J Oto-Rhino-Laryngol Relat Spec 71:268–272. https://doi.org/10.1159/000242429 CrossRef

18.

Härter MC (2000) Psychische Störungen bei körperlichen Erkrankungen. PPmP - Psychother Psychosom Med Psychol 50:274–286. https://doi.org/10.1055/s-2000-8822 CrossRef

19.

Hedner M, Larsson M, Arnold N, Zucco GM, Hummel T (2010) Cognitive factors in odor detection, odor discrimination, and odor identification tasks. J Clin Exp Neuropsychol 32:1062–1067. https://doi.org/10.1080/13803391003683070 CrossRef

20.

Hummel T, Nordin S (2005) Olfactory disorders and their consequences for quality of life. Acta Otolaryngol (Stockh) 125:116–121. https://doi.org/10.1080/00016480410022787 CrossRef

21.

Hummel T, Sekinger B, Wolf SR, Pauli E, Kobal G (1997) ‘Sniffin’ Sticks’: olfactory performance assessed by the combined testing of odour identification, odor discrimination and olfactory threshold. Chem Senses 22:39–52. https://doi.org/10.1093/chemse/22.1.39 CrossRef

22.

Hummel T, Kobal G, Gudziol H, Mackay-Sim A (2007) Normative data for the “Sniffin’ Sticks” including tests of odor identification, odor discrimination, and olfactory thresholds: an upgrade based on a group of more than 3,000 subjects. Eur Arch Otorhinolaryngol 264:237–243. https://doi.org/10.1007/s00405-006-0173-0 CrossRef

23.

Hüttenbrink KB (2008) Riech- und Schmeckstörungen - Bewährtes und Neues zu Diagnostik und Therapie*. Laryngo-Rhino-Otol. 76:506–514. https://doi.org/10.1055/s-2007-997469 CrossRef

24.

Izquierdo-Dominguez A, Jauregui I, Del Cuvillo A, Montoro J, Davila I, Sastre J, Bartra J, Ferrer M, Alobid I, Mullol J, Valero AL (2017) Allergy rhinitis: similarities and differences between children and adults. Rhinology. 55:326–331. https://doi.org/10.4193/Rhin17.074 CrossRefPubMed

25.

Keller F, Grieb J, Ernst M, Spröber N, Fegert JM, Kölch M (2011) Children’s depression rating scale – revised (CDRS-R). Z Für Kinder- Jugendpsychiatrie Psychother 39:179–185. https://doi.org/10.1024/1422-4917/a000090 CrossRef

26.

Kobal G, Hummel T, Sekinger B, Barz S, Roscher S, Wolf S (1996) “Sniffin’ Sticks”: screening of olfactory performance. Rhinology 34:222–226

27.

Koseoglu S, Derin S, Huddam B, Sahan M (2017) The effect of non-diabetic chronic renal failure on olfactory function. Eur Ann Otorhinolaryngol Head Neck Dis 134:161–164. https://doi.org/10.1016/j.anorl.2016.04.022 CrossRefPubMed

28.

Kratzmeier H, Horn R (1988) Standard progressive matrices manual. Auflage. ed. Beltz Test Gesellschaft, Weinheim, p 2

29.

Kutlug S, Gunbey E, Sogut A, Celiksoy MH, Kardas S, Yildirim U, Karli R, Murat N, Sancak R (2016) Evaluation of olfactory function in children with allergic rhinitis and nonallergic rhinitis. Int J Pediatr Otorhinolaryngol 86:172–176. https://doi.org/10.1016/j.ijporl.2016.04.038 CrossRefPubMed

30.

Langdon C, Guilemany JM, Valls M, Alobid I, Bartra J, Dávila I, Del Cuvillo A, Ferrer M, Jáuregui I, Montoro J, Sastre J, Valero A, Mullol J (2016) Allergic rhinitis causes loss of smell in children: the OLFAPEDRIAL study. Pediatr Allergy Immunol 27:867–870. https://doi.org/10.1111/pai.12655 CrossRefPubMed

31.

Loo AT, Youngentob SL, Kent PF, Schwob JE (1996) The aging olfactory epithelium: neurogenesis, response to damage, and odorant-induced activity. Int J Dev Neurosci 14:881–900. https://doi.org/10.1016/S0736-5748(96)00046-9 CrossRefPubMed

32.

Mackay-Sim A, Beard MD (1987) Hypothyroidism disrupts neural development in the olfactory epithelium of adult mice. Dev Brain Res 36:190–198. https://doi.org/10.1016/0165-3806(87)90023-X CrossRef

33.

Marschner H, Gudziol H, Guntinas-Lichius O (2010) Riechstörungen sind wesentlich häufiger als sie beklagt werden. Laryngo-Rhino-Otol. 89:654–659. https://doi.org/10.1055/s-0030-1262779 CrossRef

34.

McConnell RJ, Menendez CE, Smith FR, Henkin RI, Rivlin RS (1975) Defects of taste and smell in patients with hypothyroidism. Am J Med 59:354–364. https://doi.org/10.1016/0002-9343(75)90394-0 CrossRefPubMed

35.

Naka A, Riedl M, Luger A, Hummel T, Mueller CA (2010) Clinical significance of smell and taste disorders in patients with diabetes mellitus. Eur Arch Otorhinolaryngol 267:547–550. https://doi.org/10.1007/s00405-009-1123-4 CrossRefPubMed

36.

Oral E, Aydin MD, Aydin N, Ozcan H, Hacimuftuoglu A, Sipal S, Demirci E (2013) How olfaction disorders can cause depression? The role of habenular degeneration. Neuroscience 240:63–69. https://doi.org/10.1016/j.neuroscience.2013.02.026 CrossRefPubMed

37.

Pind J, Gunnarsdóttir EK, Jóhannesson HS (2003) Raven’s standard progressive matrices: new school age norms and a study of the test’s validity. Personal Individ Differ 34:375–386. https://doi.org/10.1016/S0191-8869(02)00058-2 CrossRef

38.

Raven J (2000) The Raven’s progressive matrices: change and stability over culture and time. Cognit Psychol 41:1–48. https://doi.org/10.1006/cogp.1999.0735 CrossRefPubMed

39.

Raven JC, Raven J, Court JH (2001) Coloured progressive matrices Stephan Bulheller, Hartmut Häcke

40.

Schriever VA, Agosin E, Altundag A, Avni H, Cao Van H, Cornejo C, de Los Santos G, Fishman G, Fragola C, Guarneros M, Gupta N, Hudson R, Kamel R, Knaapila A, Konstantinidis I, Landis BN, Larsson M, Lundström JN, Macchi A, Mariño-Sánchez F, Martinec Nováková L, Mori E, Mullol J, Nord M, Parma V, Philpott C, Propst EJ, Rawan A, Sandell M, Sorokowska A, Sorokowski P, Sparing-Paschke L-M, Stetzler C, Valder C, Vodicka J, Hummel T (2018) Development of an international odor identification test for children: the universal sniff test. J Pediatr 198:265–272.e3. https://doi.org/10.1016/j.jpeds.2018.03.011 CrossRef

41.

Schwob JE (2002) Neural regeneration and the peripheral olfactory system. Anat Rec 269:33–49. https://doi.org/10.1002/ar.10047 CrossRefPubMed

42.

Simola M, Malmberg H (1998) Sense of smell in allergic and nonallergic rhinitis. Allergy 53:190–194CrossRef

43.

Steinbach S, Reindl W, Dempfle A, Schuster A, Wolf P, Hundt W, Huber W (2013) Smell and taste in inflammatory bowel disease. PLoS One 8:e73454. https://doi.org/10.1371/journal.pone.0073454 CrossRefPubMedPubMedCentral

44.

Stevenson RJ (2010) An initial evaluation of the functions of human olfaction. Chem Senses 35:3–20. https://doi.org/10.1093/chemse/bjp083 CrossRef

45.

Stuck BA, Hummel T (2015) Olfaction in allergic rhinitis: a systematic review. J Allergy Clin Immunol 136:1460–1470. https://doi.org/10.1016/j.jaci.2015.08.003 CrossRefPubMed

46.

Weinstock RS, Wright HN, Smith DU (1993) Olfactory dysfunction in diabetes mellitus. Physiol Behav 53:17–21. https://doi.org/10.1016/0031-9384(93)90005-Z CrossRefPubMed

47.

Whitcroft KL, Cuevas M, Haehner A, Hummel T (2017) Patterns of olfactory impairment reflect underlying disease etiology. Laryngoscope 127:291–295. https://doi.org/10.1002/lary.26229 CrossRef

Titel: Influence of chronic diseases on the olfactory function in children
verfasst von: Janine Gellrich
Marie-Luise Dabow
Christian Vogelberg
Felix Reschke
Andrea Näke
Maja von der Hagen
Valentin A. Schriever
Publikationsdatum: 29.05.2019
Verlag: Springer Berlin Heidelberg
Erschienen in: European Journal of Pediatrics / Ausgabe 8/2019
Print ISSN: 0340-6199
Elektronische ISSN: 1432-1076
DOI: https://doi.org/10.1007/s00431-019-03380-1

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