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Erschienen in: European Orthopaedics and Traumatology 1/2015

01.03.2015 | Original Article

Influence of pre-operative computerized tomography on the results of surgical treatment of secondary chondrosarcomas arising on osteochondromas: a retrospective sequential cohort study

verfasst von: Jean-Charles Aurégan, Frédérique Larousserie, Valérie Dumaine, Antoine Babinet, Bernard Tomeno, Philippe Anract, Frédéric Sailhan

Erschienen in: European Orthopaedics and Traumatology | Ausgabe 1/2015

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Abstract

Purpose

Computerized tomography (CT) is routinely used for diagnosis of secondary chondrosarcomas arising on osteochondromas but its actual influence on the surgical treatment is unknown. We hypothesized that pre-operative CT helped to lower the incidence of death, local recurrence, and post-operative complications after surgical treatment of secondary chondrosarcomas.

Methods

We conducted a single center retrospective analysis on a cohort of patients treated before and after systematic utilization of pre-operative CT. We included 26 cases of secondary chondrosarcoma arising on osteochondromas (21 cases of multiple exostoses and 5 cases of a solitary exostosis) among 24 patients (10 females and 14 males, mean age of 34.5 years) at a mean follow-up of 12 years. Fourteen cases were operated on before and 12 after beginning systematic utilization of CT. We compared the two groups with a Student’s t test regarding the rates of death, recurrence, and post-operative complications.

Results

We reported a lower rate of death and recurrences in the group with pre-operative CT, but the differences were not statistically significant.

Conclusion

Despite the retrospective design and the low number of patients in this study, systematic pre-operative CT helped to improve the results of the surgical treatment of secondary chondrosarcomas arising on osteochondromas.
Literatur
1.
Zurück zum Zitat Unni KK (1996) Chondrosarcoma. In: Unni KK (ed) Dahlin’s bone tumors: general aspects and data on 11,087 cases, 5th edn. Lippincott-Raven, Philadelphia, pp 71–108 Unni KK (1996) Chondrosarcoma. In: Unni KK (ed) Dahlin’s bone tumors: general aspects and data on 11,087 cases, 5th edn. Lippincott-Raven, Philadelphia, pp 71–108
2.
Zurück zum Zitat Henderson ED, Dahlin DC (1963) Chondrosarcoma of bone: a study of two hundred and eighty-eight cases. J Bone Joint Surg Am 45-A:1450–1458 Henderson ED, Dahlin DC (1963) Chondrosarcoma of bone: a study of two hundred and eighty-eight cases. J Bone Joint Surg Am 45-A:1450–1458
3.
Zurück zum Zitat Campanacci M (1990) Peripheral chondrosarcoma. In: Campanacci M (ed) Bone and soft tissue tumors. Springer, Wien, pp 305–327CrossRef Campanacci M (1990) Peripheral chondrosarcoma. In: Campanacci M (ed) Bone and soft tissue tumors. Springer, Wien, pp 305–327CrossRef
5.
Zurück zum Zitat Jaffe HL (1958) Tumors and tumorous conditions of the bones and joints. Lea & Febiger, Philadelphia Jaffe HL (1958) Tumors and tumorous conditions of the bones and joints. Lea & Febiger, Philadelphia
6.
Zurück zum Zitat Barnes R, Catto M (1966) Chondrosarcoma of bone. J Bone Joint Surg (Br) 48-B:729–764 Barnes R, Catto M (1966) Chondrosarcoma of bone. J Bone Joint Surg (Br) 48-B:729–764
7.
Zurück zum Zitat Lichtenstein L (1972) Bone tumors, 4th edn. CV Mosby, St Louis Lichtenstein L (1972) Bone tumors, 4th edn. CV Mosby, St Louis
8.
Zurück zum Zitat Gitelis S, Bertoni F, Picci P et al (1981) Chondrosarcoma of bone: the experience at the Istituto Ortopedico Rizzoli. J Bone Joint Surg Am 63-A:1248–1257 Gitelis S, Bertoni F, Picci P et al (1981) Chondrosarcoma of bone: the experience at the Istituto Ortopedico Rizzoli. J Bone Joint Surg Am 63-A:1248–1257
9.
Zurück zum Zitat Garrison RC, Unni KK, McLeod RA et al (1982) Chondrosarcoma arising in osteochondroma. Cancer 49:1890–1897CrossRefPubMed Garrison RC, Unni KK, McLeod RA et al (1982) Chondrosarcoma arising in osteochondroma. Cancer 49:1890–1897CrossRefPubMed
10.
Zurück zum Zitat Solomon L (1974) Chondrosarcoma in hereditary multiple exostosis. S Afr Med J 48:671–676PubMed Solomon L (1974) Chondrosarcoma in hereditary multiple exostosis. S Afr Med J 48:671–676PubMed
11.
Zurück zum Zitat Schajowicz F (1994) Cartilage-forming tumors. In: Schajowicz F (ed) Tumors and tumorlike lesions of bone: pathology, radiology, and treatment. Springer, Berlin, pp 220–229CrossRef Schajowicz F (1994) Cartilage-forming tumors. In: Schajowicz F (ed) Tumors and tumorlike lesions of bone: pathology, radiology, and treatment. Springer, Berlin, pp 220–229CrossRef
12.
Zurück zum Zitat Ahmed AR, Tan TS, Unni KK et al (2003) Secondary chondrosarcoma in osteochondroma: report of 107 patients. Clin Orthop Relat Res 411:193–206CrossRefPubMed Ahmed AR, Tan TS, Unni KK et al (2003) Secondary chondrosarcoma in osteochondroma: report of 107 patients. Clin Orthop Relat Res 411:193–206CrossRefPubMed
13.
Zurück zum Zitat Giuffrida AY, Burgueno JE, Koniaris LG et al (2009) Chondrosarcoma in the United States (1973 to 2003): an analysis of 2890 cases from the SEER database. J Bone Joint Surg Am 93-A:1063–1072CrossRef Giuffrida AY, Burgueno JE, Koniaris LG et al (2009) Chondrosarcoma in the United States (1973 to 2003): an analysis of 2890 cases from the SEER database. J Bone Joint Surg Am 93-A:1063–1072CrossRef
14.
Zurück zum Zitat Lin PP, Moussallem CD, Deavers MT (2010) Secondary chondrosarcoma. J Am Acad Orthop Surg 18:608–615PubMed Lin PP, Moussallem CD, Deavers MT (2010) Secondary chondrosarcoma. J Am Acad Orthop Surg 18:608–615PubMed
15.
Zurück zum Zitat Hudson TM, Springfield DS, Spanier SS et al (1984) Benign exostoses and exostotic chondrosarcomas: evaluation of cartilage thickness by CT. Radiology 152:595–599CrossRefPubMed Hudson TM, Springfield DS, Spanier SS et al (1984) Benign exostoses and exostotic chondrosarcomas: evaluation of cartilage thickness by CT. Radiology 152:595–599CrossRefPubMed
16.
Zurück zum Zitat Hendel HW, Daugaard S, Kjaer A (2002) Utility of planar bone scintigraphy to distinguish benign osteochondromas from malignant chondrosarcomas. Clin Nucl Med 27:622–624CrossRefPubMed Hendel HW, Daugaard S, Kjaer A (2002) Utility of planar bone scintigraphy to distinguish benign osteochondromas from malignant chondrosarcomas. Clin Nucl Med 27:622–624CrossRefPubMed
17.
Zurück zum Zitat Bernard SA, Murphey MD, Flemming DJ et al (2010) Improved differentiation of benign osteochondromas from secondary chondrosarcomas with standardized measurement of cartilage cap at CT and MR imaging. Radiology 255:857–865CrossRefPubMed Bernard SA, Murphey MD, Flemming DJ et al (2010) Improved differentiation of benign osteochondromas from secondary chondrosarcomas with standardized measurement of cartilage cap at CT and MR imaging. Radiology 255:857–865CrossRefPubMed
18.
Zurück zum Zitat Feldman F, Vanheertum R, Saxena C (2006) 18-fluoro-deoxyglucose positron emission tomography evaluation of benign versus malignant osteochondromas: preliminary observations. J Comput Assist Tomogr 30:858–864CrossRefPubMed Feldman F, Vanheertum R, Saxena C (2006) 18-fluoro-deoxyglucose positron emission tomography evaluation of benign versus malignant osteochondromas: preliminary observations. J Comput Assist Tomogr 30:858–864CrossRefPubMed
19.
Zurück zum Zitat Lee FY, Yu J, Chang SS et al (2004) Diagnostic value and limitations of fluorine-18 fluorodeoxyglucose positron emission tomography for cartilaginous tumors of bone. J Bone Joint Surg Am 86-A:2677–2685PubMed Lee FY, Yu J, Chang SS et al (2004) Diagnostic value and limitations of fluorine-18 fluorodeoxyglucose positron emission tomography for cartilaginous tumors of bone. J Bone Joint Surg Am 86-A:2677–2685PubMed
20.
Zurück zum Zitat Staals EL, Bacchini P, Mercuri M et al (2007) Dedifferentiated chondrosarcomas arising in preexisting osteochondromas. J Bone Joint Surg Am 89-A:987–993CrossRef Staals EL, Bacchini P, Mercuri M et al (2007) Dedifferentiated chondrosarcomas arising in preexisting osteochondromas. J Bone Joint Surg Am 89-A:987–993CrossRef
21.
Zurück zum Zitat Peterson HA (1989) Multiple hereditary osteochondromata. Clin Orthop Relat Res 239:222–230PubMed Peterson HA (1989) Multiple hereditary osteochondromata. Clin Orthop Relat Res 239:222–230PubMed
22.
Zurück zum Zitat Pannier S, Legeai-Mallet L (2008) Hereditary multiple exostoses and enchondromatosis. Best Pract Res Clin Rheumatol 22:45–54CrossRefPubMed Pannier S, Legeai-Mallet L (2008) Hereditary multiple exostoses and enchondromatosis. Best Pract Res Clin Rheumatol 22:45–54CrossRefPubMed
23.
Zurück zum Zitat Norman A, Sissons HA (1984) Radiographic hallmarks of peripheral chondrosarcoma. Radiology 151:589–596CrossRefPubMed Norman A, Sissons HA (1984) Radiographic hallmarks of peripheral chondrosarcoma. Radiology 151:589–596CrossRefPubMed
24.
Zurück zum Zitat Lee FY, Mankin HJ, Fondren G et al (1999) Chondrosarcoma of bone: an assessment of outcome. J Bone Joint Surg Am 81-A:326–338 Lee FY, Mankin HJ, Fondren G et al (1999) Chondrosarcoma of bone: an assessment of outcome. J Bone Joint Surg Am 81-A:326–338
25.
Zurück zum Zitat Wuisman PI, Jutte PC, Ozaki T (1997) Secondary chondrosarcoma in osteochondromas: medullary extension in 15 of 45 cases. Acta Orthop Scand 68:396–400CrossRefPubMed Wuisman PI, Jutte PC, Ozaki T (1997) Secondary chondrosarcoma in osteochondromas: medullary extension in 15 of 45 cases. Acta Orthop Scand 68:396–400CrossRefPubMed
26.
Zurück zum Zitat Evans HL, Ayala AG, Romsdahl MM (1977) Prognostic factors in chondrosarcoma of bone: a clinicopathologic analysis with emphasis on histologic grading. Cancer 40:818–831CrossRefPubMed Evans HL, Ayala AG, Romsdahl MM (1977) Prognostic factors in chondrosarcoma of bone: a clinicopathologic analysis with emphasis on histologic grading. Cancer 40:818–831CrossRefPubMed
27.
Zurück zum Zitat Mankin HJ, Cantley KP, Schiller AL et al (1980) The biology of human chondrosarcoma. II. Variation in chemical composition among types and subtypes of benign and malignant cartilage tumors. J Bone Joint Surg Am 62-A:176–188 Mankin HJ, Cantley KP, Schiller AL et al (1980) The biology of human chondrosarcoma. II. Variation in chemical composition among types and subtypes of benign and malignant cartilage tumors. J Bone Joint Surg Am 62-A:176–188
28.
Zurück zum Zitat Donati D, El Ghoneimy A, Bertoni F et al (2005) Surgical treatment and outcome of conventional pelvic chondrosarcoma. J Bone Joint Surg (Br) 87-B:1527–1530CrossRef Donati D, El Ghoneimy A, Bertoni F et al (2005) Surgical treatment and outcome of conventional pelvic chondrosarcoma. J Bone Joint Surg (Br) 87-B:1527–1530CrossRef
29.
Zurück zum Zitat Björnsson J, McLeod RA, Unni KK et al (1998) Primary chondrosarcoma of long bones and limb girdles. Cancer 83:2105–2119CrossRefPubMed Björnsson J, McLeod RA, Unni KK et al (1998) Primary chondrosarcoma of long bones and limb girdles. Cancer 83:2105–2119CrossRefPubMed
Metadaten
Titel
Influence of pre-operative computerized tomography on the results of surgical treatment of secondary chondrosarcomas arising on osteochondromas: a retrospective sequential cohort study
verfasst von
Jean-Charles Aurégan
Frédérique Larousserie
Valérie Dumaine
Antoine Babinet
Bernard Tomeno
Philippe Anract
Frédéric Sailhan
Publikationsdatum
01.03.2015
Verlag
Springer Berlin Heidelberg
Erschienen in
European Orthopaedics and Traumatology / Ausgabe 1/2015
Print ISSN: 1867-4569
Elektronische ISSN: 1867-4577
DOI
https://doi.org/10.1007/s12570-014-0284-9

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