Influence of Severe Vitamin D Deficiency on the Clinical Course of Inflammatory Bowel Disease
- 26.03.2020
- Original Article
Erschienen in:
- Verfasst von
- Nam Seok Ham
- Sung Wook Hwang
- Eun Hye Oh
- Jeongseok Kim
- Ho-Su Lee
- Sang Hyoung Park
- Dong-Hoon Yang
- Byong Duk Ye
- Jeong-Sik Byeon
- Seung-Jae Myung
- Suk-Kyun Yang
- Erschienen in
- Digestive Diseases and Sciences | Ausgabe 2/2021
Abstract
Background
Previous studies have shown vitamin D status to be associated with disease activity in patients with inflammatory bowel disease (IBD), but its influence on the clinical course of IBD has not been established.
Aims
We aimed to analyze whether the serum 25-hydroxyvitamin D3 [25(OH)D] status is associated with clinical characteristics and affects the risk of surgery in patients with IBD.
Methods
From the IBD registry of the Asan Medical Center, we identified all patients who had at least one 25(OH)D measurement; we then analyzed the association between clinical factors and 25(OH)D status. 25(OH)D was considered borderline deficient, deficient, and severely deficient at levels of < 30, < 20, and < 10 ng/mL, respectively.
Results
We included 711 Crohn’s disease (CD) and 764 ulcerative colitis (UC) patients who had not undergone surgery before 25(OH)D was measured. Both in CD and in UC patients, reduced 25(OH)D was associated with higher disease activity scores and CRP levels (p < 0.001). Severe 25(OH)D deficiency was associated with ileocolonic disease and complicated behavior in CD (p < 0.05) and was relevant to the disease extent in UC (p < 0.001). Additionally, severe 25(OH)D deficiency was associated with CMV colitis in patients with UC (p < 0.001). In multivariable analysis, severe deficiency of 25(OH)D was an independent risk factor for surgery in both CD (HR 1.93, 95% confidence interval [CI] 1.38–2.70) and UC (HR 2.77, 95% CI 1.14–6.74).
Conclusion
Severe 25(OH)D deficiency may be a marker of a more aggressive clinical course of IBD.
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- Titel
- Influence of Severe Vitamin D Deficiency on the Clinical Course of Inflammatory Bowel Disease
- Verfasst von
-
Nam Seok Ham
Sung Wook Hwang
Eun Hye Oh
Jeongseok Kim
Ho-Su Lee
Sang Hyoung Park
Dong-Hoon Yang
Byong Duk Ye
Jeong-Sik Byeon
Seung-Jae Myung
Suk-Kyun Yang
- Publikationsdatum
- 26.03.2020
- Verlag
- Springer US
- Erschienen in
-
Digestive Diseases and Sciences / Ausgabe 2/2021
Print ISSN: 0163-2116
Elektronische ISSN: 1573-2568 - DOI
- https://doi.org/10.1007/s10620-020-06207-4
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