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01.06.2015 | Original Article - Cancer Research | Ausgabe 6/2015

Journal of Cancer Research and Clinical Oncology 6/2015

Influence of tumor volume on survival in patients with oral squamous cell carcinoma

Zeitschrift:
Journal of Cancer Research and Clinical Oncology > Ausgabe 6/2015
Autoren:
Thomas Mücke, David A. Mitchell, Lucas M. Ritschl, Andrea Tannapfel, Klaus-Dietrich Wolff, Marco R. Kesting, Denys J. Loeffelbein, Anastasios Kanatas

Abstract

Purpose

The TNM classification is used to assess cancers of the oral cavity, and advancements in imaging techniques have revealed clear variations in tumor volume at presentation. This study therefore aimed to clarify whether preoperative imaging, with exact measurements of the tumor, could affect post-surgery survival after controlling for demographic, clinical, and tumor characteristics.

Methods

We included 437 patients with histologically confirmed, stage T1–4, N1–3, M0, invasive squamous cell carcinoma of the tongue. Participants were assessed for recurrence every 3 months for the first 2 years, every 6 months for another 2 years, and annually thereafter; routine computed tomography was performed annually. Associations were determined using the Kaplan–Meier estimator, univariate log-rank test, and Cox proportional hazards regression models.

Results

The mean survival of all patients was 68.1 ± 48.2 months. The 2- and 5-year overall survival rates were 82.2 and 66.7 %, respectively. The mean primary tumor volume was 7.14 cm3 with a range of 1.3–24.21 cm3. The ROC curve and Youden Index analysis revealed that the optimal cutoff volume was between ≤5.9 and ≤18.3 cm3 for three different volume groups (p < 0.0001). Large tumor volume was associated with a significantly poorer overall survival (p < 0.0001).

Conclusions

Tumor volume was significantly associated with the overall survival of patients. This has both prognostic and reconstructive implications that will affect health-related quality of life. In addition, this will inform surgical planning and the allocation of resources.

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