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Journal of Cancer Research and Clinical Oncology

Erschienen in:

26.12.2016 | Review – Cancer Research

Influence of vitamin D signaling on hormone receptor status and HER2 expression in breast cancer

verfasst von: Xi Zhang, Nadia Harbeck, Udo Jeschke, Sophie Doisneau-Sixou

Erschienen in: Journal of Cancer Research and Clinical Oncology | Ausgabe 7/2017

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Abstract

Purpose

Breast cancer is a significant global public health issue. It is the leading cause of death among women around the world, with an incidence increasing annually. In recent years, there has been more and more information in the literature regarding a protective role of vitamin D in cancer. Increasingly preclinical and clinical studies suggest that vitamin D optimal levels can reduce the risk of breast cancer development and regulate cancer-related pathways.

Method

In this review, we focus on the importance of vitamin D in breast cancers, discussing especially the influence of vitamin D signaling on estrogen receptor and human epidermal growth factor receptor 2 (HER2), two major biomarkers of breast cancer today.

Conclusion

We discuss the possibility of actual and future targeted therapeutic approaches for vitamin D signaling in breast cancer.

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Titel: Influence of vitamin D signaling on hormone receptor status and HER2 expression in breast cancer
verfasst von: Xi Zhang
Nadia Harbeck
Udo Jeschke
Sophie Doisneau-Sixou
Publikationsdatum: 26.12.2016
Verlag: Springer Berlin Heidelberg
Erschienen in: Journal of Cancer Research and Clinical Oncology / Ausgabe 7/2017
Print ISSN: 0171-5216
Elektronische ISSN: 1432-1335
DOI: https://doi.org/10.1007/s00432-016-2325-y

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Influence of vitamin D signaling on hormone receptor status and HER2 expression in breast cancer

Abstract

Purpose

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Conclusion

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Live-Webinar: Aktuelle Leitlinien bei Herz-Kreislauf-Erkrankungen

Springer Medizin

Abstract

Purpose

Method

Conclusion

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