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Erschienen in: Graefe's Archive for Clinical and Experimental Ophthalmology 4/2021

16.10.2020 | Retinal Disorders

Influence of vitrectomy on the progression of dry age-related macular degeneration

verfasst von: Ilkay Kilic Muftuoglu, Tiezhu Lin, Dirk-Uwe Bartsch, William R. Freeman

Erschienen in: Graefe's Archive for Clinical and Experimental Ophthalmology | Ausgabe 4/2021

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Abstract

Purpose

To demonstrate whether pars plana vitrectomy (PPV) changes the progression of dry age-related macular degeneration (AMD) by assessing longitudinal changes in drusen volume over follow-up.

Methods

Dry AMD patients who had undergone unilateral PPV for symptomatic vitreomacular disorders were evaluated for the progression of disease by spectral domain-optical coherence tomography (SD-OCT) features including drusen volume, development of geographic atrophy, or choroidal neovascularization during follow-up. Drusen volume was manually calculated using an image processing software (ImageJ, NIH) on raster SD-OCT scans. Mean change in drusen volume of surgery eyes was compared with values of the fellow eyes of the same subjects (control group).

Results

Among 183 eyes with both vitreoretinal disorder and dry AMD, 48 eyes of 24 patients met the inclusion criteria and were included. The mean drusen volume change during a mean of 25.49 ± 23.35 months of follow-up (range: 6.00–86.87 months) was 4.236.899 ± 20.488.913 μm3 in the study eye and 7.796.357 ± 34.798.519 μm3 in the fellow eye (p = 0.297). Best-corrected visual acuity (BCVA) significantly increased from 0.40 ± 0.18 logMAR (≈ 20/50 Snellen equivalent) to 0.32 ± 0.31 (≈ 20/41 Snellen equivalent) after surgery (p = 0.012) in the study group while BCVA remained stable in the control group (0.19 ± 0.34 logMAR [≈ 20/30 Snellen equivalent] at baseline and 0.20 ± 0.31 logMAR [≈ 20/31 Snellen equivalent], p = 0.432). Choroidal neovascularization developed in 1 vitrectomized eye (4.54%) and in 1 eye (4.54%) from the control group during follow-up.

Conclusion

Vitrectomy did not seem to worsen dry AMD progression; even more visual acuity may improve despite a slight increase in drusen volume following surgery.
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Metadaten
Titel
Influence of vitrectomy on the progression of dry age-related macular degeneration
verfasst von
Ilkay Kilic Muftuoglu
Tiezhu Lin
Dirk-Uwe Bartsch
William R. Freeman
Publikationsdatum
16.10.2020
Verlag
Springer Berlin Heidelberg
Erschienen in
Graefe's Archive for Clinical and Experimental Ophthalmology / Ausgabe 4/2021
Print ISSN: 0721-832X
Elektronische ISSN: 1435-702X
DOI
https://doi.org/10.1007/s00417-020-04943-x

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