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Erschienen in: European Journal of Clinical Microbiology & Infectious Diseases 6/2016

15.03.2016 | Original Article

Influenza A and B co-infection: a case–control study and review of the literature

verfasst von: F. Pérez-García, V. Vásquez, V. de Egea, P. Catalán, B. Rodríguez-Sánchez, E. Bouza

Erschienen in: European Journal of Clinical Microbiology & Infectious Diseases | Ausgabe 6/2016

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Abstract

Influenza virus infection remains a major cause of morbidity and mortality during winter seasons. Bacterial and virus co-infection is a commonly described situation in these patients. However, data on co-infection by influenza A and B viruses are lacking. In this study, we present the cases of co-infection by influenza A and B viruses during the winter season of 2014–2015 in our institution. We analyzed 2759 samples from 2111 patients and found that 625 samples corresponding to 609 patients were positive for influenza A or B virus. A total of 371 patients had influenza A, 228 had influenza B, and 10 (1.6 %) had influenza A and B virus detection in the same sample. The median age of co-infected patients was 78.6 years, and only one of the co-infected patients died because of the infection. Comparison with a control group of mono-infected patients revealed that co-infection was significantly associated with nosocomial acquisition [odds ratio (OR) = 4.5, 95 % confidence interval (CI) = 1.05–19.25, p = 0.042]. However, co-infection was not associated with worse outcome, previous underlying condition, or vaccination status. Multivariate analysis revealed that co-infection was not an independent risk factor for death and that no single risk factor could predict co-infection.
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Metadaten
Titel
Influenza A and B co-infection: a case–control study and review of the literature
verfasst von
F. Pérez-García
V. Vásquez
V. de Egea
P. Catalán
B. Rodríguez-Sánchez
E. Bouza
Publikationsdatum
15.03.2016
Verlag
Springer Berlin Heidelberg
Erschienen in
European Journal of Clinical Microbiology & Infectious Diseases / Ausgabe 6/2016
Print ISSN: 0934-9723
Elektronische ISSN: 1435-4373
DOI
https://doi.org/10.1007/s10096-016-2620-1

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