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Erschienen in: Pediatric Nephrology 3/2011

01.03.2011 | Original Article

Influenza vaccine after pediatric kidney transplant: a Midwest Pediatric Nephrology Consortium study

verfasst von: Corina Nailescu, Xiyan Xu, Hong Zhou, Henrietta Hall, Amy C. Wilson, Jeffrey D. Leiser, Deepa H. Chand, Rudolph P. Valentini, Diane Hebert, John D. Mahan

Erschienen in: Pediatric Nephrology | Ausgabe 3/2011

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Abstract

The main aim of this study was to compare the response to trivalent inactivated influenza vaccine in children who received a kidney transplant and were on steroid-free versus steroid-based immunosuppression. Groups: 1. Kidney transplant recipients on steroid-free immunosuppression (n = 27); 2. Kidney transplant recipients on steroid-based immunosuppression (n = 39); 3. Healthy controls (n = 21). Hemagglutination inhibition titers against 2007–2008 A/H1N1 and A/H3N2 and B strains were measured before and 8 weeks postvaccination. Postvaccination geometric mean titers to A/H1N1 were significantly lower among both transplant groups than controls (p = 0.025 and 0.015, respectively). Postvaccination titers to H3N2 and B strains were not statistically different between groups. Proportions of participants developing seroprotection were not different among groups. Both kidney transplant groups seroconverted less than controls for A/H1N1 (p = 0.0002) and were no different from controls for B. For A/H3N2, the steroid-free group had the weakest seroconversion (p = 0.008), possibly due to mycophenolate-enhanced exposure and a younger age. Overall, children after kidney transplantation demonstrated a good serologic response to the inactivated influenza vaccine although somewhat lower than controls. Steroid-free immunosuppression did not seem to present an advantage in antibody response. Data on inactivated influenza vaccine safety and efficacy was collected and demonstrated absence of acute rejection or laboratory-proven influenza for 6 months postvaccination.
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Metadaten
Titel
Influenza vaccine after pediatric kidney transplant: a Midwest Pediatric Nephrology Consortium study
verfasst von
Corina Nailescu
Xiyan Xu
Hong Zhou
Henrietta Hall
Amy C. Wilson
Jeffrey D. Leiser
Deepa H. Chand
Rudolph P. Valentini
Diane Hebert
John D. Mahan
Publikationsdatum
01.03.2011
Verlag
Springer-Verlag
Erschienen in
Pediatric Nephrology / Ausgabe 3/2011
Print ISSN: 0931-041X
Elektronische ISSN: 1432-198X
DOI
https://doi.org/10.1007/s00467-010-1729-1

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