Erschienen in:
16.11.2016 | Original Article
Influenza virus infection induces translocation of apoptosis-inducing factor (AIF) in A549 cells: role of AIF in apoptosis and viral propagation
verfasst von:
Xinyan Qu, Xiaoran Ding, Ming Duan, Jing Yang, Ruxian Lin, Zhe Zhou, Shengqi Wang
Erschienen in:
Archives of Virology
|
Ausgabe 3/2017
Einloggen, um Zugang zu erhalten
Abstract
It is recognized that influenza virus induces caspase-dependent apoptosis by activating caspase-3. Apoptosis-inducing factor (AIF) is a caspase-independent cell death effector, and its mitochondrial-nuclear translocation plays an important role in apoptosis. It is demonstrated in this study how influenza virus infection can induce caspase-independent apoptosis in the human alveolar epithelial cell line A549. AIF is translocated from the mitochondria to the nucleus in a caspase-independent manner in response to infection with influenza virus. Knockdown of AIF expression by small interfering RNA (siRNA) led to a reduction in virus-infection-induced apoptosis and virus yield. These results indicate that AIF translocation has a role in influenza-virus-induced apoptosis.