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Virchows Archiv

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18.11.2016 | Brief Report

Infrequent mismatch repair protein loss in gallbladder cancer patients in Japan

verfasst von: Hiroshi Yoshida, Kazuaki Shimada, Nobuyoshi Hiraoka

Erschienen in: Virchows Archiv | Ausgabe 1/2017

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Excerpt

Gallbladder cancer (GBC) represents a rare malignancy worldwide. Its prognosis is poor, and in Chile and East Asia, including Japan and China, a relative increase in the incidence of GBC has been observed [1]. The development of new therapies is required for the treatment of this aggressive and intractable type of cancer. Recently, novel immunotherapy approaches against cancers with microsatellite instability (MSI) have been developed, and MSI is reported to be a predictive biomarker of response to treatment with pembrolizumab, an antibody against programmed cell death protein (PD-1) [2, 3]. In biliary tract cancers with MSI, this therapy might hold promise, which had increased the need for identification of MSI cancers. …

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Titel: Infrequent mismatch repair protein loss in gallbladder cancer patients in Japan
verfasst von: Hiroshi Yoshida
Kazuaki Shimada
Nobuyoshi Hiraoka
Publikationsdatum: 18.11.2016
Verlag: Springer Berlin Heidelberg
Erschienen in: Virchows Archiv / Ausgabe 1/2017
Print ISSN: 0945-6317
Elektronische ISSN: 1432-2307
DOI: https://doi.org/10.1007/s00428-016-2043-5

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