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Critical Care
Erschienen in: Critical Care 3/2009

01.06.2009 | Commentary

Inhaled activated protein C: a novel therapy for acute lung injury?

verfasst von: Kathleen D Liu, Mark R Looney, Michael A Matthay

Erschienen in: Critical Care | Ausgabe 3/2009

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Abstract

Acute lung injury (ALI) is characterized by the presence of dysregulated coagulation and inflammation. Therefore, Waerhaug and colleagues hypothesized that administration of activated protein C (APC) via the inhaled route would be a novel and effective treatment for ALI. They demonstrated that inhaled APC improved oxygenation and lung aeration in a sheep model of lipopolysaccharide-induced ALI, but did not alter lung water or hemodynamics. Future studies are needed to determine plasma and airspace APC levels when administered by the inhaled route, and to determine if inhaled APC has a similar effect in other models of ALI.
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Metadaten
Titel
Inhaled activated protein C: a novel therapy for acute lung injury?
verfasst von
Kathleen D Liu
Mark R Looney
Michael A Matthay
Publikationsdatum
01.06.2009
Verlag
BioMed Central
Erschienen in
Critical Care / Ausgabe 3/2009
Elektronische ISSN: 1364-8535
DOI
https://doi.org/10.1186/cc7869

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