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Targeted Oncology

Erschienen in:

07.12.2017 | Review Article

Inhibiting CDK in Cancer Therapy: Current Evidence and Future Directions

verfasst von: Smruthi Vijayaraghavan, Stacy Moulder, Khandan Keyomarsi, Rachel M. Layman

Erschienen in: Targeted Oncology | Ausgabe 1/2018

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Abstract

Cell cycle dysregulation is a hallmark of all cancers, resulting in uncontrolled proliferation. Cyclin dependent kinases (CDKs), a family of proteins that are involved in the regulation of the cell cycle, are frequently overexpressed or mutated in cancer. Hence, CDK-inhibiting drugs have been developed and evaluated as cancer therapeutics. Clinical trials have shown CDK4/6 inhibitors (CDK4/6i) to be relatively safe and effective, and these are now standard of care treatment for advanced hormone receptor positive breast cancer. Some CDK4/6i drugs are also able to cross the blood brain barrier and may, therefore, offer effective therapy for primary and metastatic central nervous system malignancies. Ongoing research is also evaluating CDK4/6i for additional breast cancer subtypes and non-breast malignancies with promising early phase clinical trial results. Finally, pre-clinical research has identified potential biomarkers for CDK4/6i efficacy and is exploring potential resistance mechanisms to this treatment. Further clinical-translational research is needed to advance patient selection and combinatorial treatment strategies with CDK4/6i in breast cancer and other malignancies.

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Titel: Inhibiting CDK in Cancer Therapy: Current Evidence and Future Directions
verfasst von: Smruthi Vijayaraghavan
Stacy Moulder
Khandan Keyomarsi
Rachel M. Layman
Publikationsdatum: 07.12.2017
Verlag: Springer International Publishing
Erschienen in: Targeted Oncology / Ausgabe 1/2018
Print ISSN: 1776-2596
Elektronische ISSN: 1776-260X
DOI: https://doi.org/10.1007/s11523-017-0541-2

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23.04.2024 | Medikamente in Schwangerschaft und Stillzeit | Nachrichten

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Springer Medizin

Inhibiting CDK in Cancer Therapy: Current Evidence and Future Directions

Abstract

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Live-Webinar: Aktuelle Leitlinien bei Herz-Kreislauf-Erkrankungen

Springer Medizin

Abstract

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