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29.11.2024 | Note

Inhibition of amyloid β aggregation and BACE1, and protective effect on SH-SY5Y cells, by p-terphenyl compounds from mushroom Thelephora aurantiotincta

verfasst von: Shuntaro Hirabayashi, Koji Fujihara, Takehito Saito, Hiroaki Sasaki, Shin Koike, Yuki Ogasawara, Kiyotaka Koyama, Kaoru Kinoshita

Erschienen in: Journal of Natural Medicines | Ausgabe 1/2025

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Abstract

The number of patients with Alzheimer’s disease (AD) is expected to increase as the population ages. The amyloid cascade hypothesis is proposed as the pathogenic mechanism of AD. We report the isolation and structural determination of three new p-terphenyl compounds, thelephantin P (1), thelephantin Q (2), and thelephantin R (3), with four known compounds (4–7), from the fruiting bodies of Thelephora aurantiotincta Corner. We evaluated Aβ aggregation and BACE1 inhibitory activities and neuroprotective activities of these isolated compounds. Compound 1 was shown to be multi-inhibitors for AD. Compound 1 had an IC₅₀ = 12.9 μM (Aβ), 6.3 μM (BACE1), and EC₅₀ = 8.0 μM (neuroprotection), respectively. Therefore, these compounds are potential therapeutic agents for AD.

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Titel: Inhibition of amyloid β aggregation and BACE1, and protective effect on SH-SY5Y cells, by p-terphenyl compounds from mushroom Thelephora aurantiotincta
verfasst von: Shuntaro Hirabayashi
Koji Fujihara
Takehito Saito
Hiroaki Sasaki
Shin Koike
Yuki Ogasawara
Kiyotaka Koyama
Kaoru Kinoshita
Publikationsdatum: 29.11.2024
Verlag: Springer Nature Singapore
Erschienen in: Journal of Natural Medicines / Ausgabe 1/2025
Print ISSN: 1340-3443
Elektronische ISSN: 1861-0293
DOI: https://doi.org/10.1007/s11418-024-01865-4

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