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Archives of Virology

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10.02.2018 | Brief Report

Inhibitory effect of the green tea molecule EGCG against dengue virus infection

verfasst von: Muhareva Raekiansyah, Corazon C. Buerano, Mark Anthony D. Luz, Kouichi Morita

Erschienen in: Archives of Virology | Ausgabe 6/2018

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Abstract

Dengue virus (DENV) infection is a major public health problem worldwide; however, specific antiviral drugs against it are not available. Hence, identifying effective antiviral agents for the prevention of DENV infection is important. In this study, we showed that the reportedly highly biologically active green-tea component epigallocatechin gallate (EGCG) inhibited dengue virus infection regardless of infecting serotype, but no or minimal inhibition was observed with other flaviviruses, including Japanese encephalitis virus, yellow fever virus, and Zika virus. EGCG exerted its antiviral effect mainly at the early stage of infection, probably by interacting directly with virions to prevent virus infection. Our results suggest that EGCG specifically targets DENV and might be used as a lead structure to develop an antiviral drug for use against the virus.

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Titel: Inhibitory effect of the green tea molecule EGCG against dengue virus infection
verfasst von: Muhareva Raekiansyah
Corazon C. Buerano
Mark Anthony D. Luz
Kouichi Morita
Publikationsdatum: 10.02.2018
Verlag: Springer Vienna
Erschienen in: Archives of Virology / Ausgabe 6/2018
Print ISSN: 0304-8608
Elektronische ISSN: 1432-8798
DOI: https://doi.org/10.1007/s00705-018-3769-y

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Inhibitory effect of the green tea molecule EGCG against dengue virus infection

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