Erschienen in:
19.06.2018
Innate immune cells in the adipose tissue
verfasst von:
Kyoung-Jin Chung, Marina Nati, Triantafyllos Chavakis, Antonios Chatzigeorgiou
Erschienen in:
Reviews in Endocrine and Metabolic Disorders
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Ausgabe 4/2018
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Abstract
Immune cells are present in the adipose tissue (AT) and regulate its function. Under lean conditions, immune cells predominantly of type 2 immunity, including eosinophils, M2-like anti-inflammatory macrophages and innate lymphoid cells 2, contribute to the maintenance of metabolic homeostasis within the AT. In the course of obesity, pro-inflammatory immune cells, such as M1-like macrophages, prevail in the AT. Inflammation in the obese AT is associated with the development of metabolic complications such as insulin resistance, type 2 diabetes and cardiovascular disease. Thus, the immune cell-adipocyte crosstalk in the AT is an important regulator of AT function and systemic metabolism. We discuss herein this crosstalk with a special focus on the role of innate immune cells in AT inflammation and metabolic homeostasis in obesity.