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Rheumatology International

Erschienen in:

01.02.2016 | Review Article - Pathogenesis Reviews

Innate immune cells in the pathogenesis of primary systemic vasculitis

verfasst von: Durga Prasanna Misra, Vikas Agarwal

Erschienen in: Rheumatology International | Ausgabe 2/2016

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Abstract

Innate immune system forms the first line of defense against foreign substances. Neutrophils, eosinophils, erythrocytes, platelets, monocytes, macrophages, dendritic cells, γδ T cells, natural killer and natural killer T cells comprise the innate immune system. Genetic polymorphisms influencing the activation of innate immune cells predispose to development of vasculitis and influence its severity. Abnormally activated innate immune cells cross-talk with other cells of the innate immune system, present antigens more efficiently and activate T and B lymphocytes and cause tissue destruction via cell-mediated cytotoxicity and release of pro-inflammatory cytokines. These secreted cytokines further recruit other cells to the sites of vascular injury. They are involved in both the initiation as well as the perpetuation of vasculitis. Evidences suggest reversal of aberrant activation of immune cells in response to therapy. Understanding the role of innate immune cells in vasculitis helps understand the potential of therapeutic modulation of their activation to treat vasculitis.

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Titel: Innate immune cells in the pathogenesis of primary systemic vasculitis
verfasst von: Durga Prasanna Misra
Vikas Agarwal
Publikationsdatum: 01.02.2016
Verlag: Springer Berlin Heidelberg
Erschienen in: Rheumatology International / Ausgabe 2/2016
Print ISSN: 0172-8172
Elektronische ISSN: 1437-160X
DOI: https://doi.org/10.1007/s00296-015-3367-1

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