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Erschienen in: Current Bladder Dysfunction Reports 2/2018

28.04.2018 | Overactive Bladder (U Lee and S Adelstein, Section Editors)

Insight Into the Central Control of Overactive Bladder Symptoms by Functional Brain Imaging

verfasst von: Justina Tam, Tal Cohen, Jason Kim, Steven Weissbart

Erschienen in: Current Bladder Dysfunction Reports | Ausgabe 2/2018

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Abstract

Purpose of Review

The goal of this paper is to review the data on brain activity in individuals with overactive bladder that has been gleaned by the use of functional neuroimaging.

Recent Findings

Recent studies have demonstrated that there are differences in brain activity in individuals with overactive bladder (including anterior cingulate cortex, insula, and prefrontal cortex activation) and have shown that treatment of overactive bladder results in brain activity changes.

Summary

Functional neuroimaging has provided considerable insight into central nervous system control of micturition and the alterations seen in individuals with overactive bladder. Further work may improve our understanding of the pathogenesis of overactive bladder and how its treatments work and thereby allow identification of patient factors that permit individualized counseling.
Literatur
1.
Zurück zum Zitat Stewart W, Van Rooyen J, Cundiff G, Abrams P, Herzog A, Corey R, et al. Prevalence and burden of overactive bladder in the United States. World J Urol. 2003;20(6):327–36.PubMed Stewart W, Van Rooyen J, Cundiff G, Abrams P, Herzog A, Corey R, et al. Prevalence and burden of overactive bladder in the United States. World J Urol. 2003;20(6):327–36.PubMed
3.
Zurück zum Zitat Coyne KS, Sexton CC, Thompson CL, Clemens JQ, Chen CI, Bavendam T, et al. Impact of overactive bladder on work productivity. Urology. 2012;80(1):97–103.CrossRefPubMed Coyne KS, Sexton CC, Thompson CL, Clemens JQ, Chen CI, Bavendam T, et al. Impact of overactive bladder on work productivity. Urology. 2012;80(1):97–103.CrossRefPubMed
4.
Zurück zum Zitat Hanna-Mitchell AT, Kashyap M, Chan WV, Andersson KE, Tannenbaum C. Pathophysiology of idiopathic overactive bladder and the success of treatment: a systematic review from ICI-RS 2013. Neurourol Urodyn. 2014;33(5):611–7.CrossRefPubMed Hanna-Mitchell AT, Kashyap M, Chan WV, Andersson KE, Tannenbaum C. Pathophysiology of idiopathic overactive bladder and the success of treatment: a systematic review from ICI-RS 2013. Neurourol Urodyn. 2014;33(5):611–7.CrossRefPubMed
5.
Zurück zum Zitat Fukuyama H, Matsuzaki S, Ouchi Y, Yamauchi H, Nagahama Y, Kimura J, et al. Neural control of micturition in man examined with single photon emission computed tomography using 99mTc-HMPAO. Neuroreport. 1996;7(18):3009–12.CrossRefPubMed Fukuyama H, Matsuzaki S, Ouchi Y, Yamauchi H, Nagahama Y, Kimura J, et al. Neural control of micturition in man examined with single photon emission computed tomography using 99mTc-HMPAO. Neuroreport. 1996;7(18):3009–12.CrossRefPubMed
6.
Zurück zum Zitat Blok BF, Willemsen AT, Holstege G. A PET study on brain control of micturition in humans. Brain J Neurol. 1997;120(1):111–21.CrossRef Blok BF, Willemsen AT, Holstege G. A PET study on brain control of micturition in humans. Brain J Neurol. 1997;120(1):111–21.CrossRef
7.
Zurück zum Zitat Zhang H, Reitz A, Kollias S, Summers P, Curt A, Schurch B. An fMRI study of the role of suprapontine brain structures in the voluntary voiding control induced by pelvic floor contraction. NeuroImage. 2005;24(1):174–80.CrossRefPubMed Zhang H, Reitz A, Kollias S, Summers P, Curt A, Schurch B. An fMRI study of the role of suprapontine brain structures in the voluntary voiding control induced by pelvic floor contraction. NeuroImage. 2005;24(1):174–80.CrossRefPubMed
8.
Zurück zum Zitat Mayer EA, Naliboff BD, Craig AB. Neuroimaging of the brain-gut axis: from basic understanding to treatment of functional GI disorders. Gastroenterology. 2006;131(6):1925–42.CrossRefPubMed Mayer EA, Naliboff BD, Craig AB. Neuroimaging of the brain-gut axis: from basic understanding to treatment of functional GI disorders. Gastroenterology. 2006;131(6):1925–42.CrossRefPubMed
9.
Zurück zum Zitat Blok BF, Holstege G. The central nervous system control of micturition in cats and humans. Behav Brain Res. 1998;92(2):119–25.CrossRefPubMed Blok BF, Holstege G. The central nervous system control of micturition in cats and humans. Behav Brain Res. 1998;92(2):119–25.CrossRefPubMed
10.
Zurück zum Zitat Matsuura S, Kakizaki H, Mitsui T, Shiga T, Tamaki N, Koyanagi T. Human brain region response to distention or cold stimulation of the bladder: a positron emission tomography study. J Urol. 2002;168(5):2035–9.CrossRefPubMed Matsuura S, Kakizaki H, Mitsui T, Shiga T, Tamaki N, Koyanagi T. Human brain region response to distention or cold stimulation of the bladder: a positron emission tomography study. J Urol. 2002;168(5):2035–9.CrossRefPubMed
11.
Zurück zum Zitat Griffiths D, Tadic SD, Schaefer W, Resnick NM. Cerebral control of the bladder in normal and urge-incontinent women. NeuroImage. 2007;37(1):1–7.CrossRefPubMedPubMedCentral Griffiths D, Tadic SD, Schaefer W, Resnick NM. Cerebral control of the bladder in normal and urge-incontinent women. NeuroImage. 2007;37(1):1–7.CrossRefPubMedPubMedCentral
12.
Zurück zum Zitat Craig AD. How do you feel? Interoception: the sense of the physiological condition of the body. Nat Rev Neurosci. 2002;3(8):655–66.CrossRefPubMed Craig AD. How do you feel? Interoception: the sense of the physiological condition of the body. Nat Rev Neurosci. 2002;3(8):655–66.CrossRefPubMed
13.
Zurück zum Zitat Fowler C. Brain activation during micturition. Brain J Neurol. 1998;121(11):2031–2.CrossRef Fowler C. Brain activation during micturition. Brain J Neurol. 1998;121(11):2031–2.CrossRef
15.
Zurück zum Zitat Griffiths D. Neural control of micturition in humans: a working model. Nat Rev Urol. 2015;12(12):695–705.CrossRefPubMed Griffiths D. Neural control of micturition in humans: a working model. Nat Rev Urol. 2015;12(12):695–705.CrossRefPubMed
16.
Zurück zum Zitat Athwal BS, Berkley KJ, Hussain I, Brennan A, Craggs M, Sakakibara R, et al. Brain responses to changes in bladder volume and urge to void in healthy men. Brain. 2001;124(2):369–77.CrossRefPubMed Athwal BS, Berkley KJ, Hussain I, Brennan A, Craggs M, Sakakibara R, et al. Brain responses to changes in bladder volume and urge to void in healthy men. Brain. 2001;124(2):369–77.CrossRefPubMed
17.
Zurück zum Zitat Kavia RBC, Dasgupta R, Fowler CJ. Functional imaging and the central control of the bladder. J Comp Neurol. 2005;493(1):27–32.CrossRefPubMed Kavia RBC, Dasgupta R, Fowler CJ. Functional imaging and the central control of the bladder. J Comp Neurol. 2005;493(1):27–32.CrossRefPubMed
18.
Zurück zum Zitat •• Arya NG, Weissbart SJ, Xu S, Rao H. Brain activation in response to bladder filling in healthy adults: an activation likelihood estimation meta-analysis of neuroimaging studies. Neurourol Urodyn. 2017;36(4):960–5. Meta-analysis identifying brain regions that are often identified during bladder filling in healthy adults. CrossRefPubMed •• Arya NG, Weissbart SJ, Xu S, Rao H. Brain activation in response to bladder filling in healthy adults: an activation likelihood estimation meta-analysis of neuroimaging studies. Neurourol Urodyn. 2017;36(4):960–5. Meta-analysis identifying brain regions that are often identified during bladder filling in healthy adults. CrossRefPubMed
19.
Zurück zum Zitat Portas CM, Rees G, Howseman A, Josephs O, Turner R, Frith CD. A specific role for the thalamus in mediating the interaction of attention and arousal in humans. J Neurosci. 1998;18(21):8979–89.CrossRefPubMed Portas CM, Rees G, Howseman A, Josephs O, Turner R, Frith CD. A specific role for the thalamus in mediating the interaction of attention and arousal in humans. J Neurosci. 1998;18(21):8979–89.CrossRefPubMed
20.
Zurück zum Zitat Michels L, Blok BF, Gregorini F, Kurz M, Schurch B, Kessler TM, et al. Supraspinal control of urine storage and micturition in men—an fMRI study. Cereb Cortex. 2014;25(10):3369–80.CrossRefPubMedPubMedCentral Michels L, Blok BF, Gregorini F, Kurz M, Schurch B, Kessler TM, et al. Supraspinal control of urine storage and micturition in men—an fMRI study. Cereb Cortex. 2014;25(10):3369–80.CrossRefPubMedPubMedCentral
21.
Zurück zum Zitat Griffiths D, Derbyshire S, Stenger A, Resnick N. Brain control of normal and overactive bladder. J Urol. 2005;174(5):1862–7.CrossRefPubMed Griffiths D, Derbyshire S, Stenger A, Resnick N. Brain control of normal and overactive bladder. J Urol. 2005;174(5):1862–7.CrossRefPubMed
22.
Zurück zum Zitat Kuhtz-Buschbeck J, Van der Horst C, Wolff S, Filippow N, Nabavi A, Jansen O, et al. Activation of the supplementary motor area (SMA) during voluntary pelvic floor muscle contractions—an fMRI study. NeuroImage. 2007;35(2):449–57.CrossRefPubMed Kuhtz-Buschbeck J, Van der Horst C, Wolff S, Filippow N, Nabavi A, Jansen O, et al. Activation of the supplementary motor area (SMA) during voluntary pelvic floor muscle contractions—an fMRI study. NeuroImage. 2007;35(2):449–57.CrossRefPubMed
23.
Zurück zum Zitat Griffiths D, Tadic SD. Bladder control, urgency, and urge incontinence: evidence from functional brain imaging. Neurourol Urodyn. 2008;27(6):466–74.CrossRefPubMed Griffiths D, Tadic SD. Bladder control, urgency, and urge incontinence: evidence from functional brain imaging. Neurourol Urodyn. 2008;27(6):466–74.CrossRefPubMed
24.
Zurück zum Zitat Komesu YM, Ketai LH, Mayer AR, Teshiba TM, Rogers RG. Functional MRI of the brain in women with overactive bladder: brain activation during urinary urgency. Female Pelvic Med Reconstr Surg. 2011;17(1):50.CrossRefPubMedPubMedCentral Komesu YM, Ketai LH, Mayer AR, Teshiba TM, Rogers RG. Functional MRI of the brain in women with overactive bladder: brain activation during urinary urgency. Female Pelvic Med Reconstr Surg. 2011;17(1):50.CrossRefPubMedPubMedCentral
25.
Zurück zum Zitat Pfisterer MHD, Griffiths DJ, Resnick NM. The effect of age on lower urinary tract function: a study in women. J Am Geriatr Soc. 2006;54(3):405–12.CrossRefPubMed Pfisterer MHD, Griffiths DJ, Resnick NM. The effect of age on lower urinary tract function: a study in women. J Am Geriatr Soc. 2006;54(3):405–12.CrossRefPubMed
26.
Zurück zum Zitat Griffiths DJ, Tadic SD, Schaefer W, Resnick NM. Cerebral control of the lower urinary tract: how age-related changes might predispose to urge incontinence. NeuroImage. 2009;47(3):981–6.CrossRefPubMedPubMedCentral Griffiths DJ, Tadic SD, Schaefer W, Resnick NM. Cerebral control of the lower urinary tract: how age-related changes might predispose to urge incontinence. NeuroImage. 2009;47(3):981–6.CrossRefPubMedPubMedCentral
27.
Zurück zum Zitat Kuchel GA, Moscufo N, Guttmann CR, Zeevi N, Wakefield D, Schmidt J, et al. Localization of brain white matter hyperintensities and urinary incontinence in community-dwelling older adults. J Gerontol Series A: Biomed Sci Med Sci. 2009;64((8):902–9.CrossRef Kuchel GA, Moscufo N, Guttmann CR, Zeevi N, Wakefield D, Schmidt J, et al. Localization of brain white matter hyperintensities and urinary incontinence in community-dwelling older adults. J Gerontol Series A: Biomed Sci Med Sci. 2009;64((8):902–9.CrossRef
28.
Zurück zum Zitat Tadic SD, Griffiths D, Murrin A, Schaefer W, Aizenstein HJ, Resnick NM. Brain activity during bladder filling is related to white matter structural changes in older women with urinary incontinence. NeuroImage. 2010;51(4):1294–302.CrossRefPubMedPubMedCentral Tadic SD, Griffiths D, Murrin A, Schaefer W, Aizenstein HJ, Resnick NM. Brain activity during bladder filling is related to white matter structural changes in older women with urinary incontinence. NeuroImage. 2010;51(4):1294–302.CrossRefPubMedPubMedCentral
29.
Zurück zum Zitat Tadic SD, Griffiths D, Schaefer W, Resnick NM. Abnormal connections in the supraspinal bladder control network in women with urge urinary incontinence. NeuroImage. 2008;39(4):1647–53.CrossRefPubMed Tadic SD, Griffiths D, Schaefer W, Resnick NM. Abnormal connections in the supraspinal bladder control network in women with urge urinary incontinence. NeuroImage. 2008;39(4):1647–53.CrossRefPubMed
30.
Zurück zum Zitat Yin Y, Shuke N, Okizaki A, Sato J, Aburano T, Li Y, et al. Cerebral activation during withholding urine with full bladder in healthy men using 99mTc-HMPAO SPECT. J Nucl Med. 2006;47(7):1093–8.PubMed Yin Y, Shuke N, Okizaki A, Sato J, Aburano T, Li Y, et al. Cerebral activation during withholding urine with full bladder in healthy men using 99mTc-HMPAO SPECT. J Nucl Med. 2006;47(7):1093–8.PubMed
31.
Zurück zum Zitat Kuhtz-Buschbeck JP, van der HORSTC, Pott C, Wolff S, Nabavi A, Jansen O, et al. Cortical representation of the urge to void: a functional magnetic resonance imaging study. J Urol. 2005;174(4):1477–81.CrossRefPubMed Kuhtz-Buschbeck JP, van der HORSTC, Pott C, Wolff S, Nabavi A, Jansen O, et al. Cortical representation of the urge to void: a functional magnetic resonance imaging study. J Urol. 2005;174(4):1477–81.CrossRefPubMed
32.
Zurück zum Zitat • Nardos R, Karstens L, Carpenter S, Aykes K, Krisky C, Stevens C, et al. Abnormal functional connectivity in women with urgency urinary incontinence: Can we predict disease presence and severity in individual women using Rs-fcMRI. Neurourol Urodyn. 2016;35(5):564–73. Cross-sectional study comparing brain functional connectivity in subjects with and without urgency urinary incontinence demonstrated that connectivity data may be used to differentiate normal subjects from those with urgency urinary incontinence. CrossRefPubMed • Nardos R, Karstens L, Carpenter S, Aykes K, Krisky C, Stevens C, et al. Abnormal functional connectivity in women with urgency urinary incontinence: Can we predict disease presence and severity in individual women using Rs-fcMRI. Neurourol Urodyn. 2016;35(5):564–73. Cross-sectional study comparing brain functional connectivity in subjects with and without urgency urinary incontinence demonstrated that connectivity data may be used to differentiate normal subjects from those with urgency urinary incontinence. CrossRefPubMed
33.
Zurück zum Zitat • Arya NG, Weissbart SJ, Xu S, Bhavsar R, Rao H. Quantitative changes in cerebral perfusion during urinary urgency in women with overactive bladder. BioMed Research International. 2017;2017. First study using arterial spin labeling to study changes in cerebral perfusion in subjects with overactive bladder, and demonstrated changes in regional cerebral blood flow in subjects with OAB may be associated with with abnormal processing of afferent input in the limbic cortex. • Arya NG, Weissbart SJ, Xu S, Bhavsar R, Rao H. Quantitative changes in cerebral perfusion during urinary urgency in women with overactive bladder. BioMed Research International. 2017;2017. First study using arterial spin labeling to study changes in cerebral perfusion in subjects with overactive bladder, and demonstrated changes in regional cerebral blood flow in subjects with OAB may be associated with with abnormal processing of afferent input in the limbic cortex.
34.
Zurück zum Zitat Pontari MA, Mohamed FB, Lebovitch S, Moonat S, Lebed B, Ruggieri MR, et al. Central nervous system findings on functional magnetic resonance imaging in patients before and after treatment with anticholinergic medication. J Urol. 2010;183(5):1899–905.CrossRefPubMed Pontari MA, Mohamed FB, Lebovitch S, Moonat S, Lebed B, Ruggieri MR, et al. Central nervous system findings on functional magnetic resonance imaging in patients before and after treatment with anticholinergic medication. J Urol. 2010;183(5):1899–905.CrossRefPubMed
35.
Zurück zum Zitat • Griffiths D, Clarkson B, Tadic SD, Resnick NM. Brain mechanisms underlying urge incontinence and its response to pelvic floor muscle training. J Urol. 2015;194(3):708–15. Demonstrated that brain response to bladder filling may be able to predict the success or failure of a behavioral treatment for urgency urinary incontinence. CrossRefPubMedPubMedCentral • Griffiths D, Clarkson B, Tadic SD, Resnick NM. Brain mechanisms underlying urge incontinence and its response to pelvic floor muscle training. J Urol. 2015;194(3):708–15. Demonstrated that brain response to bladder filling may be able to predict the success or failure of a behavioral treatment for urgency urinary incontinence. CrossRefPubMedPubMedCentral
36.
Zurück zum Zitat Blok BF, Groen J, Bosch J, Veltman DJ, Lammertsma AA. Different brain effects during chronic and acute sacral neuromodulation in urge incontinent patients with implanted neurostimulators. BJU Int. 2006;98(6):1238–43.CrossRefPubMed Blok BF, Groen J, Bosch J, Veltman DJ, Lammertsma AA. Different brain effects during chronic and acute sacral neuromodulation in urge incontinent patients with implanted neurostimulators. BJU Int. 2006;98(6):1238–43.CrossRefPubMed
37.
Zurück zum Zitat • Gill BC, Pizarro-Berdichevsky J, Bhattacharyya PK, Brink TS, Marks BK, Quirouet A, et al. Real-time changes in brain activity during sacral neuromodulation for overactive bladder. J Urol. 2017;198(6):1379–85. First study to evaluate real-time changes in brain activity during SNS for OAB. Their work demonstrated that sacral neuromodulation alters brain activity in subjects with OAB who responded to treatment. CrossRefPubMed • Gill BC, Pizarro-Berdichevsky J, Bhattacharyya PK, Brink TS, Marks BK, Quirouet A, et al. Real-time changes in brain activity during sacral neuromodulation for overactive bladder. J Urol. 2017;198(6):1379–85. First study to evaluate real-time changes in brain activity during SNS for OAB. Their work demonstrated that sacral neuromodulation alters brain activity in subjects with OAB who responded to treatment. CrossRefPubMed
38.
Zurück zum Zitat • Elizondo RA, Karmonik C, Boone TB, Khavari R. Protocol for a prospective observational study of cortical lower urinary tract control changes following intradetrusor injection of botulinum toxin-A in patients with multiple sclerosis. BMJ Open. 2017;7(2):e013225. This novel study protocol aims to investigating the central effects of intradetrusor injection of botulinum toxin-A in individuals with multiple sclerosis. CrossRefPubMedPubMedCentral • Elizondo RA, Karmonik C, Boone TB, Khavari R. Protocol for a prospective observational study of cortical lower urinary tract control changes following intradetrusor injection of botulinum toxin-A in patients with multiple sclerosis. BMJ Open. 2017;7(2):e013225. This novel study protocol aims to investigating the central effects of intradetrusor injection of botulinum toxin-A in individuals with multiple sclerosis. CrossRefPubMedPubMedCentral
39.
Zurück zum Zitat • Weissbart S, Bhavsar R, Detre J, Rao H, Wein A, Arya L, et al. PNFBA-05 Specific changes in brain activity in women with overactive bladder after successful sacral neuromodulation with Interstim®: an fMRI study. J Urol. 2017;197(4):e610–e1. Demonstrates that SNS mitigates increased brain activity in subjects with OAB and suggests that subjects with OAB and increased brain activity during bladder filling may have better response to treatment. CrossRef • Weissbart S, Bhavsar R, Detre J, Rao H, Wein A, Arya L, et al. PNFBA-05 Specific changes in brain activity in women with overactive bladder after successful sacral neuromodulation with Interstim®: an fMRI study. J Urol. 2017;197(4):e610–e1. Demonstrates that SNS mitigates increased brain activity in subjects with OAB and suggests that subjects with OAB and increased brain activity during bladder filling may have better response to treatment. CrossRef
41.
Zurück zum Zitat • Clarkson BD, Tyagi S, Griffiths DJ, Resnick NM. Test-retest repeatability of patterns of brain activation provoked by bladder filling. Neurourol Urodyn. 2017;36(6):1472–8. First evaluation of the repeatability of a bladder fMRI protocol, demonstrating limited repeatability of brain response to bladder filling in individual subjects. CrossRefPubMed • Clarkson BD, Tyagi S, Griffiths DJ, Resnick NM. Test-retest repeatability of patterns of brain activation provoked by bladder filling. Neurourol Urodyn. 2017;36(6):1472–8. First evaluation of the repeatability of a bladder fMRI protocol, demonstrating limited repeatability of brain response to bladder filling in individual subjects. CrossRefPubMed
42.
Zurück zum Zitat • Leitner L, Walter M, Jarrahi B, Wanek J, Diefenbacher J, Michels L, et al. A novel infusion-drainage device to assess lower urinary tract function in neuro-imaging. BJU Int. 2017;119(2):305–16. Evaluates the use of a novel device to aid in standardization of bladder filling and emptying protocols. CrossRefPubMed • Leitner L, Walter M, Jarrahi B, Wanek J, Diefenbacher J, Michels L, et al. A novel infusion-drainage device to assess lower urinary tract function in neuro-imaging. BJU Int. 2017;119(2):305–16. Evaluates the use of a novel device to aid in standardization of bladder filling and emptying protocols. CrossRefPubMed
43.
Zurück zum Zitat Resnick NM, Perera S, Tadic S, Organist L, Riley MA, Schaefer W, et al. What predicts and what mediates the response of urge urinary incontinence to biofeedback? Neurourol Urodyn. 2013;32(5):408–15.CrossRefPubMed Resnick NM, Perera S, Tadic S, Organist L, Riley MA, Schaefer W, et al. What predicts and what mediates the response of urge urinary incontinence to biofeedback? Neurourol Urodyn. 2013;32(5):408–15.CrossRefPubMed
Metadaten
Titel
Insight Into the Central Control of Overactive Bladder Symptoms by Functional Brain Imaging
verfasst von
Justina Tam
Tal Cohen
Jason Kim
Steven Weissbart
Publikationsdatum
28.04.2018
Verlag
Springer US
Erschienen in
Current Bladder Dysfunction Reports / Ausgabe 2/2018
Print ISSN: 1931-7212
Elektronische ISSN: 1931-7220
DOI
https://doi.org/10.1007/s11884-018-0464-5

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