Skip to main content
Erschienen in: Journal of General Internal Medicine 7/2020

26.02.2020 | Original Research

Instability in End-of-Life Care Preference Among Heart Failure Patients: Secondary Analysis of a Randomized Controlled Trial in Singapore

verfasst von: Chetna Malhotra, MD, Meibo Hu, MSSc, Rahul Malhotra, MD, David Sim, MBBS, Fazlur Rehman Jaufeerally, MMChB, Filipinas G. Bundoc, MA, Eric A. Finkelstein, PhD

Erschienen in: Journal of General Internal Medicine | Ausgabe 7/2020

Einloggen, um Zugang zu erhalten

Abstract

Background

Efforts to improve quality of end-of-life (EOL) care are increasingly focused on eliciting patients’ EOL preference through advance care planning (ACP). However, if patients’ EOL preference changes over time and their ACP documents are not updated, these documents may no longer be valid at the time EOL decisions are made.

Objectives

To assess extent and correlates of changes in stated preference for aggressive EOL care over time.

Design

Secondary analysis of data from a randomized controlled trial of a formal ACP program versus usual care in Singapore.

Patients

Two hundred eighty-two patients with heart failure (HF) and New York Heart Association Classification III and IV symptoms were recruited and interviewed every 4 months for up to 2 years to assess their preference for EOL care. Analytic sample included 200 patients interviewed at least twice.

Results

Nearly two thirds (64%) of patients changed their preferred type of EOL care at least once. Proportion of patients changing their stated preference for type of EOL care increased with time and the change was not unidirectional. Patients who understood their prognosis correctly were less likely to change their preference from non-aggressive to aggressive EOL care (OR 0.66, p value 0.07) or to prefer aggressive EOL care (OR 0.53; p value 0.001). On the other hand, patient-surrogate discussion of care preference was associated with a higher likelihood of change in patient preference from aggressive to non-aggressive EOL care (OR 1.83; p value 0.03).

Conclusion

The study provides evidence of instability in HF patients’ stated EOL care preference. This undermines the value of an ACP document recorded months before EOL decisions are made unless a strategy exists for easily updating this preference.

Trial Registration

ClinicalTrials.gov: NCT02299180
Anhänge
Nur mit Berechtigung zugänglich
Literatur
1.
Zurück zum Zitat Bruera E, Sweeney C, Calder K, Palmer L, Benisch-Tolley S. Patient preferences versus physician perceptions of treatment decisions in cancer care. J Clin Oncol Off J Am Soc Clin Oncol. 2001; 19(11): 2883–5. Bruera E, Sweeney C, Calder K, Palmer L, Benisch-Tolley S. Patient preferences versus physician perceptions of treatment decisions in cancer care. J Clin Oncol Off J Am Soc Clin Oncol. 2001; 19(11): 2883–5.
2.
Zurück zum Zitat Degner LF, Kristjanson LJ, Bowman D, Sloan JA, Carriere KC, O'Neil J, et al. Information Needs and Decisional Preferences in Women With Breast Cancer. JAMA. 1997; 277(18): 1485–92.PubMed Degner LF, Kristjanson LJ, Bowman D, Sloan JA, Carriere KC, O'Neil J, et al. Information Needs and Decisional Preferences in Women With Breast Cancer. JAMA. 1997; 277(18): 1485–92.PubMed
3.
Zurück zum Zitat Pardon K, Deschepper R, Vander Stichele R, Bernheim J, Mortier F, Schallier D, et al. Are patients’ preferences for information and participation in medical decision-making being met? Interview study with lung cancer patients. Palliat Med. 2010; 25(1): 62–70.PubMed Pardon K, Deschepper R, Vander Stichele R, Bernheim J, Mortier F, Schallier D, et al. Are patients’ preferences for information and participation in medical decision-making being met? Interview study with lung cancer patients. Palliat Med. 2010; 25(1): 62–70.PubMed
4.
Zurück zum Zitat Detering KM, Hancock AD, Reade MC, Silvester W. The impact of advance care planning on end of life care in elderly patients: randomised controlled trial. BMJ. 2010; 340. Detering KM, Hancock AD, Reade MC, Silvester W. The impact of advance care planning on end of life care in elderly patients: randomised controlled trial. BMJ. 2010; 340.
5.
Zurück zum Zitat Briggs LA, Kirchhoff KT, Hammes BJ, Song M-K, Colvin ER. Patient-centered advance care planning in special patient populations: a pilot study. J Prof Nurs. 2004; 20(1): 47–58.PubMed Briggs LA, Kirchhoff KT, Hammes BJ, Song M-K, Colvin ER. Patient-centered advance care planning in special patient populations: a pilot study. J Prof Nurs. 2004; 20(1): 47–58.PubMed
6.
Zurück zum Zitat El-Jawahri A, Paasche-Orlow MK, Matlock D, Stevenson LW, Lewis EF, Stewart G, et al. Randomized, Controlled Trial of an Advance Care Planning Video Decision Support Tool for Patients With Advanced Heart FailureClinical Perspective. Circulation. 2016; 134(1): 52–60.PubMedPubMedCentral El-Jawahri A, Paasche-Orlow MK, Matlock D, Stevenson LW, Lewis EF, Stewart G, et al. Randomized, Controlled Trial of an Advance Care Planning Video Decision Support Tool for Patients With Advanced Heart FailureClinical Perspective. Circulation. 2016; 134(1): 52–60.PubMedPubMedCentral
7.
Zurück zum Zitat Lyon ME, Jacobs S, Briggs L, Cheng Y, Wang J. Family-centered advance care planning for teens with cancer. JAMA Pediatr. 2013; 167(5): 460–7.PubMed Lyon ME, Jacobs S, Briggs L, Cheng Y, Wang J. Family-centered advance care planning for teens with cancer. JAMA Pediatr. 2013; 167(5): 460–7.PubMed
8.
Zurück zum Zitat Song M-K, Ward SE, Fine JP, Hanson LC, Lin F-C, Hladik GA, et al. Advance Care Planning and End-of-Life Decision Making in Dialysis: A Randomized Controlled Trial Targeting Patients and Their Surrogates. Am J Kidney Dis. 2015; 66(5): 813–22.PubMedPubMedCentral Song M-K, Ward SE, Fine JP, Hanson LC, Lin F-C, Hladik GA, et al. Advance Care Planning and End-of-Life Decision Making in Dialysis: A Randomized Controlled Trial Targeting Patients and Their Surrogates. Am J Kidney Dis. 2015; 66(5): 813–22.PubMedPubMedCentral
9.
Zurück zum Zitat Auriemma CL, Nguyen CA, Bronheim R, Kent S, Nadiger S, Pardo D, et al. Stability of End-of-Life Preferences: A Systematic Review of the EvidenceStability of End-of-Life PreferencesStability of End-of-Life Preferences. JAMA Intern Med. 2014; 174(7): 1085–92.PubMed Auriemma CL, Nguyen CA, Bronheim R, Kent S, Nadiger S, Pardo D, et al. Stability of End-of-Life Preferences: A Systematic Review of the EvidenceStability of End-of-Life PreferencesStability of End-of-Life Preferences. JAMA Intern Med. 2014; 174(7): 1085–92.PubMed
10.
Zurück zum Zitat McKim DA, King J, Walker K, Leblanc C, Timpson D, Wilson KG, et al. Formal ventilation patient education for ALS predicts real-life choices. Amyotroph Lateral Scler. 2012; 13(1): 59–65.PubMed McKim DA, King J, Walker K, Leblanc C, Timpson D, Wilson KG, et al. Formal ventilation patient education for ALS predicts real-life choices. Amyotroph Lateral Scler. 2012; 13(1): 59–65.PubMed
11.
Zurück zum Zitat Sharman SJ. Current negative mood encourages changes in end-of-life treatment decisions and is associated with false memories. Cognit Emot. 2011; 25(1): 132–9. Sharman SJ. Current negative mood encourages changes in end-of-life treatment decisions and is associated with false memories. Cognit Emot. 2011; 25(1): 132–9.
12.
Zurück zum Zitat Eggar R, Spencer A, Anderson D, Hiller L. Views of elderly patients on cardiopulmonary resuscitation before and after treatment for depression. Int J Geriatr Psychiatry. 2002; 17(2): 170–4.PubMed Eggar R, Spencer A, Anderson D, Hiller L. Views of elderly patients on cardiopulmonary resuscitation before and after treatment for depression. Int J Geriatr Psychiatry. 2002; 17(2): 170–4.PubMed
13.
Zurück zum Zitat Golin CE, Wenger NS, Liu H, Dawson NV. A prospective study of patient-physician communication about resuscitation. J Am Geriatr Soc. 2000; 48(5): S52.PubMed Golin CE, Wenger NS, Liu H, Dawson NV. A prospective study of patient-physician communication about resuscitation. J Am Geriatr Soc. 2000; 48(5): S52.PubMed
14.
Zurück zum Zitat Malcomson H, Bisbee S. Perspectives of healthy elders on advance care planning. J Am Acad Nurse Pract. 2009; 21(1): 18–23.PubMed Malcomson H, Bisbee S. Perspectives of healthy elders on advance care planning. J Am Acad Nurse Pract. 2009; 21(1): 18–23.PubMed
15.
Zurück zum Zitat Bravo G, Trottier L, Arcand M, Boire-Lavigne A-M, Blanchette D, Dubois M-F, et al. Promoting advance care planning among community-based older adults: A randomized controlled trial. Patient Educ Couns. 2016; 99(11): 1785–95.PubMed Bravo G, Trottier L, Arcand M, Boire-Lavigne A-M, Blanchette D, Dubois M-F, et al. Promoting advance care planning among community-based older adults: A randomized controlled trial. Patient Educ Couns. 2016; 99(11): 1785–95.PubMed
16.
Zurück zum Zitat Stewart S, MacIntyre K, Hole DJ, Capewell S, McMurray JJV. More 'malignant' than cancer? Five-year survival following a first admission for heart failure. Eur J Heart Fail. 2001; 3(3): 315–22.PubMed Stewart S, MacIntyre K, Hole DJ, Capewell S, McMurray JJV. More 'malignant' than cancer? Five-year survival following a first admission for heart failure. Eur J Heart Fail. 2001; 3(3): 315–22.PubMed
17.
Zurück zum Zitat Askoxylakis V, Thieke C, Pleger ST, Most P, Tanner J, Lindel K, et al. Long-term survival of cancer patients compared to heart failure and stroke: A systematic review. BMC Cancer. 2010; 10(1): 105.PubMedPubMedCentral Askoxylakis V, Thieke C, Pleger ST, Most P, Tanner J, Lindel K, et al. Long-term survival of cancer patients compared to heart failure and stroke: A systematic review. BMC Cancer. 2010; 10(1): 105.PubMedPubMedCentral
18.
Zurück zum Zitat Emanuel LL, Emanuel EJ, Stoeckle JD, Hummel LR, Barry MJ. Advance Directives: Stability of Patients' Treatment Choices. Arch Intern Med. 1994; 154(2): 209–17.PubMed Emanuel LL, Emanuel EJ, Stoeckle JD, Hummel LR, Barry MJ. Advance Directives: Stability of Patients' Treatment Choices. Arch Intern Med. 1994; 154(2): 209–17.PubMed
19.
Zurück zum Zitat Danis M, Garrett J, Harris R, Patrick DL. Stability of Choices about Life-Sustaining Treatments. Ann Intern Med. 1994; 120(7): 567–73.PubMed Danis M, Garrett J, Harris R, Patrick DL. Stability of Choices about Life-Sustaining Treatments. Ann Intern Med. 1994; 120(7): 567–73.PubMed
20.
Zurück zum Zitat Ditto PH, Smucker WD, Danks JH, Jacobson JA, Houts RM, Fagerlin A, et al. Stability of Older Adults' Preferences for Life-Sustaining Medical Treatment. Health Psychol. 2003; 22(6): 605–15.PubMed Ditto PH, Smucker WD, Danks JH, Jacobson JA, Houts RM, Fagerlin A, et al. Stability of Older Adults' Preferences for Life-Sustaining Medical Treatment. Health Psychol. 2003; 22(6): 605–15.PubMed
21.
Zurück zum Zitat Carmel S, Mutran E. Wishes regarding the use of life-sustaining treatments among elderly persons in Israel: An explanatory model. Soc Sci Med. 1997; 45(11): 1715–27.PubMed Carmel S, Mutran E. Wishes regarding the use of life-sustaining treatments among elderly persons in Israel: An explanatory model. Soc Sci Med. 1997; 45(11): 1715–27.PubMed
22.
Zurück zum Zitat Fried TR, Van Ness PH, Byers AL, Towle VR, O’Leary JR, Dubin JA. Changes in Preferences for Life-Sustaining Treatment Among Older Persons with Advanced Illness. J Gen Intern Med. 2007; 22(4): 495–501.PubMedPubMedCentral Fried TR, Van Ness PH, Byers AL, Towle VR, O’Leary JR, Dubin JA. Changes in Preferences for Life-Sustaining Treatment Among Older Persons with Advanced Illness. J Gen Intern Med. 2007; 22(4): 495–501.PubMedPubMedCentral
23.
Zurück zum Zitat Fried TR, O'Leary J, Van Ness P, Fraenkel L. Inconsistency Over Time in the Preferences of Older Persons with Advanced Illness for Life-Sustaining Treatment. J Am Geriatr Soc. 2007; 55(7): 1007–14.PubMedPubMedCentral Fried TR, O'Leary J, Van Ness P, Fraenkel L. Inconsistency Over Time in the Preferences of Older Persons with Advanced Illness for Life-Sustaining Treatment. J Am Geriatr Soc. 2007; 55(7): 1007–14.PubMedPubMedCentral
24.
Zurück zum Zitat Rosenfeld KE, Wenger NS, Phillips RS, Connors AF, Dawson NV, Layde P, et al. Factors Associated With Change in Resuscitation Preference of Seriously Ill Patients. Arch Intern Med. 1996; 156(14): 1558–64.PubMed Rosenfeld KE, Wenger NS, Phillips RS, Connors AF, Dawson NV, Layde P, et al. Factors Associated With Change in Resuscitation Preference of Seriously Ill Patients. Arch Intern Med. 1996; 156(14): 1558–64.PubMed
25.
Zurück zum Zitat Janssen DJA, Spruit MA, Schols JMGA, Cox B, Nawrot TS, Curtis JR, et al. Predicting Changes in Preferences for Life-Sustaining Treatment Among Patients With Advanced Chronic Organ Failure. Chest. 2012; 141(5): 1251–9.PubMed Janssen DJA, Spruit MA, Schols JMGA, Cox B, Nawrot TS, Curtis JR, et al. Predicting Changes in Preferences for Life-Sustaining Treatment Among Patients With Advanced Chronic Organ Failure. Chest. 2012; 141(5): 1251–9.PubMed
26.
Zurück zum Zitat Weeks JC, Cook EF, O'Day SJ, Peterson LM, Wenger N, Reding D, et al. Relationship Between Cancer Patients' Predictions of Prognosis and Their Treatment Preferences. JAMA. 1998; 279(21): 1709–14.PubMed Weeks JC, Cook EF, O'Day SJ, Peterson LM, Wenger N, Reding D, et al. Relationship Between Cancer Patients' Predictions of Prognosis and Their Treatment Preferences. JAMA. 1998; 279(21): 1709–14.PubMed
27.
Zurück zum Zitat Davison SN. End-of-Life Care Preferences and Needs: Perceptions of Patients with Chronic Kidney Disease. Clin J Am Soc Nephrol. 2010; 5(2): 195.PubMedPubMedCentral Davison SN. End-of-Life Care Preferences and Needs: Perceptions of Patients with Chronic Kidney Disease. Clin J Am Soc Nephrol. 2010; 5(2): 195.PubMedPubMedCentral
28.
Zurück zum Zitat Aiken LS, Butner J, Lockhart CA, Volk-Craft BE, Hamilton G, Williams FG. Outcome evaluation of a randomized trial of the PhoenixCare intervention: program of case management and coordinated care for the seriously chronically ill. J Palliat Med. 2006; 9(1): 111–26.PubMed Aiken LS, Butner J, Lockhart CA, Volk-Craft BE, Hamilton G, Williams FG. Outcome evaluation of a randomized trial of the PhoenixCare intervention: program of case management and coordinated care for the seriously chronically ill. J Palliat Med. 2006; 9(1): 111–26.PubMed
29.
Zurück zum Zitat Allen RS, Allen JY, Hilgeman MM, DeCoster J. End-of-Life Decision-Making, Decisional Conflict, and Enhanced Information: Race Effects. J Am Geriatr Soc. 2008; 56(10): 1904–9.PubMed Allen RS, Allen JY, Hilgeman MM, DeCoster J. End-of-Life Decision-Making, Decisional Conflict, and Enhanced Information: Race Effects. J Am Geriatr Soc. 2008; 56(10): 1904–9.PubMed
30.
Zurück zum Zitat Heyland DK, Heyland R, Dodek P, You JJ, Sinuff T, Hiebert T, et al. Discordance between patients' stated values and treatment preferences for end-of-life care: results of a multicentre survey. BMJ Support Palliat Care. 2017; 7(3): 292.PubMed Heyland DK, Heyland R, Dodek P, You JJ, Sinuff T, Hiebert T, et al. Discordance between patients' stated values and treatment preferences for end-of-life care: results of a multicentre survey. BMJ Support Palliat Care. 2017; 7(3): 292.PubMed
31.
Zurück zum Zitat Song M-K, Ward SE, Hanson LC, Metzger M, Kim S. Determining Consistency of Surrogate Decisions and End-of-Life Care Received with Patient Goals-of-Care Preferences. J Palliat Med. 2016; 19(6): 610–6.PubMedPubMedCentral Song M-K, Ward SE, Hanson LC, Metzger M, Kim S. Determining Consistency of Surrogate Decisions and End-of-Life Care Received with Patient Goals-of-Care Preferences. J Palliat Med. 2016; 19(6): 610–6.PubMedPubMedCentral
32.
Zurück zum Zitat Silveira MJ, Kim SYH, Langa KM. Advance Directives and Outcomes of Surrogate Decision Making before Death. N Engl J Med. 2010; 362(13): 1211–8.PubMedPubMedCentral Silveira MJ, Kim SYH, Langa KM. Advance Directives and Outcomes of Surrogate Decision Making before Death. N Engl J Med. 2010; 362(13): 1211–8.PubMedPubMedCentral
34.
Zurück zum Zitat Hammes BJ, Rooney BL, Gundrum JD. A Comparative, Retrospective, Observational Study of the Prevalence, Availability, and Specificity of Advance Care Plans in a County that Implemented an Advance Care Planning Microsystem. J Am Geriatr Soc. 2010; 58(7): 1249–55.PubMed Hammes BJ, Rooney BL, Gundrum JD. A Comparative, Retrospective, Observational Study of the Prevalence, Availability, and Specificity of Advance Care Plans in a County that Implemented an Advance Care Planning Microsystem. J Am Geriatr Soc. 2010; 58(7): 1249–55.PubMed
35.
Zurück zum Zitat Green CP, Porter CB, Bresnahan DR, Spertus JA. Development and evaluation of the Kansas City Cardiomyopathy Questionnaire: a new health status measure for heart failure. J Am Coll Cardiol. 2000; 35(5): 1245–55.PubMed Green CP, Porter CB, Bresnahan DR, Spertus JA. Development and evaluation of the Kansas City Cardiomyopathy Questionnaire: a new health status measure for heart failure. J Am Coll Cardiol. 2000; 35(5): 1245–55.PubMed
36.
Zurück zum Zitat Bjelland I, Dahl AA, Haug TT, Neckelmann D. The validity of the Hospital Anxiety and Depression Scale. An updated literature review. J Psychosom Res. 2002; 52(2): 69–77.PubMed Bjelland I, Dahl AA, Haug TT, Neckelmann D. The validity of the Hospital Anxiety and Depression Scale. An updated literature review. J Psychosom Res. 2002; 52(2): 69–77.PubMed
37.
Zurück zum Zitat Herrmann C. International experiences with the Hospital Anxiety and Depression Scale--a review of validation data and clinical results. J Psychosom Res. 1997; 42(1): 17–41.PubMed Herrmann C. International experiences with the Hospital Anxiety and Depression Scale--a review of validation data and clinical results. J Psychosom Res. 1997; 42(1): 17–41.PubMed
38.
Zurück zum Zitat O'Connor AM. Validation of a decisional conflict scale. Med Decis Mak. 1995; 15(1): 25–30. O'Connor AM. Validation of a decisional conflict scale. Med Decis Mak. 1995; 15(1): 25–30.
39.
Zurück zum Zitat Tueller SJ, Van Dorn RA, Bobashev GV. Visualization of categorical longitudinal and times series data. Methods report (RTI Press). 2016; 2016. Tueller SJ, Van Dorn RA, Bobashev GV. Visualization of categorical longitudinal and times series data. Methods report (RTI Press). 2016; 2016.
40.
Zurück zum Zitat Allison TA, Sudore RL. Disregard of Patients’ Preferences Is a Medical Error: Comment on “Failure to Engage Hospitalized Elderly Patients and Their Families in Advance Care Planning” Disregard of Patients’ Preferences. JAMA Intern Med.. 2013; 173(9): 787.PubMed Allison TA, Sudore RL. Disregard of Patients’ Preferences Is a Medical Error: Comment on “Failure to Engage Hospitalized Elderly Patients and Their Families in Advance Care Planning” Disregard of Patients’ Preferences. JAMA Intern Med.. 2013; 173(9): 787.PubMed
41.
Zurück zum Zitat Ozdemir S, Finkelstein EA. Cognitive Bias: The Downside of Shared Decision Making. JCO Clin Cancer Inform. 2018; 2: 1–10.PubMed Ozdemir S, Finkelstein EA. Cognitive Bias: The Downside of Shared Decision Making. JCO Clin Cancer Inform. 2018; 2: 1–10.PubMed
42.
Zurück zum Zitat Ozdemir S, Jafar TH, Choong LHL, Finkelstein EA. Family dynamics in a multi-ethnic Asian society: comparison of elderly CKD patients and their family caregivers experience with medical decision making for managing end stage kidney disease. BMC Nephrol. 2019; 20(1): 73.PubMedPubMedCentral Ozdemir S, Jafar TH, Choong LHL, Finkelstein EA. Family dynamics in a multi-ethnic Asian society: comparison of elderly CKD patients and their family caregivers experience with medical decision making for managing end stage kidney disease. BMC Nephrol. 2019; 20(1): 73.PubMedPubMedCentral
43.
Zurück zum Zitat Lin M-L, Kan W-M, Chen C-H. Patients' Perceptions and Expectations of Family Participation in the Informed Consent Process of Elective Surgery in Taiwan. Asian Nurs Res. 2012; 6(2): 55–9. Lin M-L, Kan W-M, Chen C-H. Patients' Perceptions and Expectations of Family Participation in the Informed Consent Process of Elective Surgery in Taiwan. Asian Nurs Res. 2012; 6(2): 55–9.
45.
Zurück zum Zitat Heiat A, Gross CP, Krumholz HM. Representation of the elderly, women, and minorities in heart failure clinical trials. Arch Intern Med. 2002; 162(15): 1682–8.PubMed Heiat A, Gross CP, Krumholz HM. Representation of the elderly, women, and minorities in heart failure clinical trials. Arch Intern Med. 2002; 162(15): 1682–8.PubMed
46.
Zurück zum Zitat Pilote L, Raparelli V. Participation of Women in Clinical Trials. J Am Coll Cardiol. 2018; 71(18): 1970.PubMed Pilote L, Raparelli V. Participation of Women in Clinical Trials. J Am Coll Cardiol. 2018; 71(18): 1970.PubMed
47.
Zurück zum Zitat Melloni C, Berger Jeffrey S, Wang Tracy Y, Gunes F, Stebbins A, Pieper Karen S, et al. Representation of Women in Randomized Clinical Trials of Cardiovascular Disease Prevention. Circ Cardiovasc Qual Outcomes. 2010; 3(2): 135–42.PubMed Melloni C, Berger Jeffrey S, Wang Tracy Y, Gunes F, Stebbins A, Pieper Karen S, et al. Representation of Women in Randomized Clinical Trials of Cardiovascular Disease Prevention. Circ Cardiovasc Qual Outcomes. 2010; 3(2): 135–42.PubMed
Metadaten
Titel
Instability in End-of-Life Care Preference Among Heart Failure Patients: Secondary Analysis of a Randomized Controlled Trial in Singapore
verfasst von
Chetna Malhotra, MD
Meibo Hu, MSSc
Rahul Malhotra, MD
David Sim, MBBS
Fazlur Rehman Jaufeerally, MMChB
Filipinas G. Bundoc, MA
Eric A. Finkelstein, PhD
Publikationsdatum
26.02.2020
Verlag
Springer International Publishing
Erschienen in
Journal of General Internal Medicine / Ausgabe 7/2020
Print ISSN: 0884-8734
Elektronische ISSN: 1525-1497
DOI
https://doi.org/10.1007/s11606-020-05740-2

Weitere Artikel der Ausgabe 7/2020

Journal of General Internal Medicine 7/2020 Zur Ausgabe

Leitlinien kompakt für die Innere Medizin

Mit medbee Pocketcards sicher entscheiden.

Seit 2022 gehört die medbee GmbH zum Springer Medizin Verlag

Update Innere Medizin

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.