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Current Oral Health Reports

Erschienen in:

19.03.2020 | Oral Disease and Nutrition (F Nishimura, Section Editor)

Insulin Function in Peripheral Taste Organ Homeostasis

verfasst von: Shingo Takai, Noriatsu Shigemura

Erschienen in: Current Oral Health Reports | Ausgabe 2/2020

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Abstract

Purpose of Review

Taste is the sensory system primarily devoted to the selection of what we eat. Various internal factors are likely involved in the modulation of taste sensitivity or homeostasis in the context of one’s general nutritional condition. For ameliorating or preventing lifestyle-related diseases, it is important to understand how our taste system is maintained and disrupted. This review focuses on insulin, the most potent anabolic agent in our body and a possible modulator of taste sensation, in the peripheral taste system.

Recent Findings

The insulin receptor is expressed in taste buds and taste progenitor/stem cells. Insulin expression itself is also reported in taste buds. Recent studies suggest that insulin signaling might contribute to the regulation of taste cell generation.

Summary

Insulin in blood circulation or in taste buds might influence taste cell turnover and certain taste sensitivities. Hyperinsulinemia is one possible cause of taste disorders frequently observed in diabetes patients.

Chandrashekar J, Hoon MA, Ryba NJP, Zuker CS. The receptors and cells for mammalian taste. Nature. 2006. https://doi.org/10.1038/nature05401.

Takai S, Yoshida R, Shigemura N, Ninomiya Y. Peptide signaling in taste transduction. In: Chemosens. Transduct: Elsevier; 2016. p. 299–317.

Yoshida R, Ninomiya Y. New insights into the signal transmission from taste cells to gustatory nerve fibers. Int Rev Cell Mol Biol. 2010;279:101–34.PubMedCrossRef

Roper SD, Chaudhari N. Taste buds: cells, signals and synapses. Nat Rev Neurosci. 2017. https://doi.org/10.1038/nrn.2017.68.

Huang AL, Chen X, Hoon MA, Chandrashekar J, Guo W, Tränkner D, et al. The cells and logic for mammalian sour taste detection. Nature. 2006;442:934–8.PubMedPubMedCentralCrossRef

Ishimaru Y, Inada H, Kubota M, Zhuang H, Tominaga M, Matsunami H. Transient receptor potential family members PKD1L3 and PKD2L1 form a candidate sour taste receptor. Proc Natl Acad Sci U S A. 2006;103:12569–74.PubMedPubMedCentralCrossRef

Teng B, Wilson CE, Tu Y-H, Joshi NR, Kinnamon SC, Liman Correspondence ER, et al. Cellular and neural responses to sour stimuli require the proton channel Otop1 article cellular and neural responses to sour stimuli require the Proton Channel Otop1. Curr Biol. 2019;29:3647–56.PubMedCrossRefPubMedCentral

Roper SD. Taste buds as peripheral chemosensory processors. Semin Cell Dev Biol. 2013. https://doi.org/10.1016/j.semcdb.2012.12.002.

Chaudhari N, Roper SD (2010) The cell biology of taste 190:285–296.

10.

Ichimori Y, Ueda K, Okada H, Honma S, Wakisaka S. Histochemical changes and apoptosis in degenerating taste buds of the rat circumvallate papilla. Arch Histol Cytol. 2009;72:91–100.PubMedCrossRef

11.

Miura H, Scott JK, Harada S, Barlow LA. Sonic hedgehog -expressing basal cells are general post-mitotic precursors of functional taste receptor cells. Dev Dyn. 2014;243:1286–97.PubMedPubMedCentralCrossRef

12.

Ohmoto M, Ren W, Nishiguchi Y, Hirota J, Jiang P, Matsumoto I. Genetic lineage tracing in taste tissues using Sox2-CreERT2 strain. Chem Senses. 2017;42:547–52.PubMedPubMedCentralCrossRef

13.

Tanaka T, Komai Y, Tokuyama Y, Yanai H, Ohe S, Okazaki K, et al. Identification of stem cells that maintain and regenerate lingual keratinized epithelial cells. Nat Cell Biol. 2013;15:511–8.PubMedCrossRef

14.

Beidler LM, Smallman RL. Renewal of cells within taste buds. J Cell Biol. 1965;27:263–72.PubMedPubMedCentralCrossRef

15.

Hamamichi R, Asano-Miyoshi M, Emori Y. Taste bud contains both short-lived and long-lived cell populations. Neuroscience. 2006;141:2129–38.PubMedCrossRef

16.

Perea-Martinez I, Nagai T, Chaudhari N. Functional cell types in taste buds have distinct longevities. PLoS One. 2013;8:e53399.PubMedPubMedCentralCrossRef

17.

Yee KK, Li Y, Redding KM, Iwatsuki K, Margolskee RF, Jiang P. Lgr5-EGFP Marks taste bud stem/progenitor cells in posterior tongue. Stem Cells. 2013;31:992–1000.PubMedPubMedCentralCrossRef

18.

Ren W, Lewandowski BC, Watson J, Aihara E, Iwatsuki K, Bachmanov AA, et al. Single Lgr5- or Lgr6-expressing taste stem/progenitor cells generate taste bud cells ex vivo. Proc Natl Acad Sci. 2014. https://doi.org/10.1073/pnas.1409064111.

19.

Zhou Y, Liu H-X, Mistretta CM. Bone morphogenetic proteins and noggin: inhibiting and inducing fungiform taste papilla development. Dev Biol. 2006;297:198–213.PubMedCrossRef

20.

Liebl DJ, Mbiene J-P, Parada LF. NT4/5 mutant mice have deficiency in gustatory papillae and taste bud formation. Dev Biol. 1999;213:378–89.PubMedCrossRef

21.

Petersen CI, Jheon AH, Mostowfi P, Charles C, Ching S, Thirumangalathu S, et al. FGF signaling regulates the number of posterior taste papillae by controlling progenitor field size. PLoS Genet. 2011;7:e1002098.PubMedPubMedCentralCrossRef

22.

Biggs BT, Tang T, Krimm RF. Insulin-like growth factors are expressed in the taste system, but do not maintain adult taste buds. PLoS One. 2016. https://doi.org/10.1371/journal.pone.0148315.

23.

Lu WJ, Mann RK, Nguyen A, Bi T, Silverstein M, Tang JY, et al. Neuronal delivery of hedgehog directs spatial patterning of taste organ regeneration. Proc Natl Acad Sci U S A. 2017;115:E200–9.PubMedPubMedCentralCrossRef

24.

Iwatsuki K, Liu H-X, Gronder A, Singer MA, Lane TF, Grosschedl R, et al. Wnt signaling interacts with Shh to regulate taste papilla development. Proc Natl Acad Sci. 2007;104:2253–8.PubMedCrossRefPubMedCentral

25.

Saltiel AR, Kahn CR. Insulin signalling and the regulation of glucose and lipid metabolism. Nature. 2001;414:799–806.PubMedCrossRef

26.

Baquero AF, Gilbertson TA. Insulin activates epithelial sodium channel (ENaC) via phosphoinositide 3-kinase in mammalian taste receptor cells. Am J Physiol Physiol. 2011;300:C860–71.CrossRef

27.

Heck GL, Mierson S, Desimone JA. Salt taste transduction occurs through an amiloride-sensitive sodium transport pathway. Science. 1984;223:403–5.PubMedCrossRef

28.

Blazer-Yost BL, Liu X, Helman SI. Hormonal regulation of eNaCs: insulin and aldosterone. Am J Phys Cell Phys. 1998. https://doi.org/10.1152/ajpcell.1998.274.5.c1373.

29.

Wang J, Barbry P, Maiyar AC, Rozansky DJ, Bhargava A, Leong M, et al. SGK integrates insulin and mineralocorticoid regulation of epithelial sodium transport. Am J Physiol Ren Physiol. 2001. https://doi.org/10.1152/ajprenal.2001.280.2.f303.

30.

• Doyle ME, Fiori JL, Gonzalez Mariscal I, Liu Q-R, Goodstein E, Yang H, et al. Insulin is transcribed and translated in mammalian taste bud cells. Endocrinology. 2018;159:3331–9. Firstly discovered insulin production in oral tissue in mice and human, however they did not mentioned about its function.

31.

Calvo SSC, Egan JM. The endocrinology of taste receptors. Nat Rev Endocrinol. 2015;11:213–27. https://doi.org/10.1038/nrendo.2015.7.CrossRefPubMed

32.

Shin Y-K, Martin B, Kim W, et al. Ghrelin is produced in taste cells and ghrelin receptor null mice show reduced taste responsivity to salty (NaCl) and sour (citric acid) tastants. PLoS One. 2010;5:e12729.PubMedPubMedCentralCrossRef

33.

Elson AET, Dotson CD, Egan JM, Munger SD. Glucagon signaling modulates sweet taste responsiveness. FASEB J. 2010. https://doi.org/10.1096/fj.10-158105.

34.

Yee KK, Sukumaran SK, Kotha R, Gilbertson TA, Margolskee RF. Glucose transporters and ATP-gated K+ (KATP) metabolic sensors are present in type 1 taste receptor 3 (T1r3)-expressing taste cells. Proc Natl Acad Sci U S A. 2011;108:5431–6.PubMedPubMedCentralCrossRef

35.

Shin YK, Martin B, Golden E, Dotson CD, Maudsley S, Kim W, et al. Modulation of taste sensitivity by GLP-1 signaling. J Neurochem. 2008;106:455–63.PubMedPubMedCentralCrossRef

36.

•• Takai S, Watanabe Y, Sanematsu K, Yoshida R, Margolskee RF, Jiang P, et al. Effects of insulin signaling on mouse taste cell proliferation. PLoS One. 2019;14:e0225190. Proved that insulin from circulation (or within taste tissue) could make impact on taste cell differentiation/proliferation with using newly developed 3-D stem cell culture of taste buds.

37.

Dazert E, Hall MN. mTOR signaling in disease. Curr Opin Cell Biol. 2011;23:744–55.PubMedCrossRef

38.

Avruch J, Long X, Ortiz-Vega S, Rapley J, Papageorgiou A, Dai N. Amino acid regulation of TOR complex 1. Am J Physiol Metab. 2009;296:E592–602.

39.

Ma XM, Blenis J. Molecular mechanisms of mTOR-mediated translational control. Nat Rev Mol Cell Biol. 2009;10:307–18.PubMedCrossRef

40.

Zoncu R, Efeyan A, Sabatini DM. MTOR: from growth signal integration to cancer, diabetes and ageing. Nat Rev Mol Cell Biol. 2011. https://doi.org/10.1038/nrm3025.

41.

Hay N, Sonenberg N. Upstream and downstream of mTOR. Genes Dev. 2004;18:1926–45.CrossRefPubMed

42.

Wirawan E, Vanden Berghe T, Lippens S, Agostinis P, Vandenabeele P. Autophagy: for better or for worse. Cell Res. 2012;22:43–61.PubMedCrossRef

43.

Suzuki Y, Takeda M, Sakakura Y, Suzuki N. Distinct expression pattern of insulin-like growth factor family in rodent taste buds. J Comp Neurol. 2005;482:74–84.PubMedCrossRef

44.

Biggs BT, Tang T, Krimm RF. Insulin-like growth factors are expressed at high levels in the taste system, but do not maintain taste bud structure. Chem Senses. 2015;40:600.

45.

Zhang C, Cotter M, Lawton A, Oakley B, Wong L, Zeng Q. Keratin 18 is associated with a subset of older taste cells in the rat. Differentiation. 1995;59:155–62.PubMedCrossRef

46.

Suzuki Y, Takeda M, Sakakura Y, Suzuki N. Distinct expression pattern of insulin-like growth factor family in rodent taste buds. J Comp Neurol. 2005;482:74–84.PubMedCrossRef

47.

Schumachers R, Mosthafs L, Schlessingerj J, Brandenburgll D, Ullrichs A (1991) THE JOURNAL OF BIOLOGICAL CHEMISTRY insulin and insulin-like growth factor-1 binding specificity is determined by distinct regions of their cognate receptors*.

48.

Nakae J, Kido Y, Accili D Distinct and Overlapping Functions of Insulin and IGF-I Receptors.

49.

Kawaguchi H, Murata K. Electric gustatory threshold in diabetics and its clinical significance. Nippon Jibiinkoka Gakkai Kaiho. 1995;98:1291–12961363.PubMedCrossRef

50.

Schelling JL, Tetreault L, Lasagna L, Davis M. Abnormal taste threshold in diabetes. Lancet (London, England). 1965;1:508–12.CrossRef

51.

De Carli L, Gambino R, Lubrano C, Rosato R, Bongiovanni D, Lanfranco F, et al. Impaired taste sensation in type 2 diabetic patients without chronic complications: a case–control study. J Endocrinol Investig. 2018;41:765–72.CrossRef

52.

Gondivkar SM, Indurkar A, Degwekar S, Bhowate R. Evaluation of gustatory function in patients with diabetes mellitus type 2. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2009;108:876–80.PubMedCrossRef

53.

Wasalathanthri S, Hettiarachchi P, Prathapan S. Sweet taste sensitivity in pre-diabetics, diabetics and normoglycemic controls: a comparative cross sectional study. BMC Endocr Disord. 2014;14:67.PubMedPubMedCentralCrossRef

54.

Yu JH, Shin MS, Lee JR, Choi JH, Koh EH, Lee WJ, et al. Decreased sucrose preference in patients with type 2 diabetes mellitus. Diabetes Res Clin Pract. 2014;104:214–9.PubMedCrossRef

55.

Yoon M-S. The role of mammalian target of Rapamycin (mTOR) in insulin signaling. Nutrients. 2017. https://doi.org/10.3390/nu9111176.

56.

Le Floch JP, Le Lievre G, Sadoun J, Perlemuter L, Peynegre R, Hazard J. Taste impairment and related factors in type I diabetes mellitus. Diabetes Care. 1989;12:173–8.PubMedCrossRef

57.

Hardy SL, Brennand CP, Wyse BW. Taste thresholds of individuals with diabetes mellitus and of control subjects. J Am Diet Assoc. 1981;79:286–9.PubMed

58.

Pavlidis P, Gouveris H, Kekes G, Maurer J. Electrogustometry thresholds, tongue tip vascularization, and density and morphology of the fungiform papillae in diabetes. B-ENT. 2014;10:271–8.PubMed

59.

Le Floch JP, Le Lièvre G, Verroust J, Philippon C, Peynegre R, Perlemuter L. Factors related to the electric taste threshold in type 1 diabetic patients. Diabet Med. 1990;7:526–31.PubMedCrossRef

60.

Abbasi AA. Diabetes: diagnostic and therapeutic significance of taste impairment. Geriatrics. 1981;36:73–8.PubMed

61.

Negrato C, Tarzia O. Buccal alterations in diabetes mellitus. Diabetol Metab Syndr. 2010;2:1–11. https://doi.org/10.1186/1758-5996-2-3.CrossRef

62.

Takai S, Yasumatsu K, Inoue M, Iwata S, Yoshida R, Shigemura N, et al. Glucagon-like peptide-1 is specifically involved in sweet taste transmission. FASEB J. 2015. https://doi.org/10.1096/fj.14-265355.

63.

Martin B, Dotson CD, Shin YK, Ji S, Drucker DJ, Maudsley S, et al. Modulation of taste sensitivity by GLP-1 signaling in taste buds. Ann N Y Acad Sci. 2009. https://doi.org/10.1111/j.1749-6632.2009.03920.x.

64.

Noel CA, Sugrue M, Dando R. Participants with pharmacologically impaired taste function seek out more intense, higher calorie stimuli. Appetite. 2017;117:74–81.PubMedCrossRef

Titel: Insulin Function in Peripheral Taste Organ Homeostasis
verfasst von: Shingo Takai
Noriatsu Shigemura
Publikationsdatum: 19.03.2020
Verlag: Springer International Publishing
Erschienen in: Current Oral Health Reports / Ausgabe 2/2020
Elektronische ISSN: 2196-3002
DOI: https://doi.org/10.1007/s40496-020-00266-2

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Insulin Function in Peripheral Taste Organ Homeostasis

Abstract

Purpose of Review

Recent Findings

Summary

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Summary

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