Erschienen in:
01.03.2009 | Original Paper
Insulin-like growth factor-1 is essential to the increased mortality caused by excess growth hormone: a case of thyroid cancer and non-Hodgkin’s lymphoma in a patient with pituitary acromegaly
verfasst von:
A. Taslipinar, E. Bolu, L. Kebapcilar, M. Sahin, G. Uckaya, M. Kutlu
Erschienen in:
Medical Oncology
|
Ausgabe 1/2009
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Abstract
The effects of growth hormone are mediated in part by stimulating the production of insulin-like growth factor-1. Insulin-like growth factor-1 has significant effects on cell proliferation and differentiation, it is a potent mitogen, and it is a powerful inhibitor of programmed cell death (apoptosis). Insulin-like growth factor-1 also has a well-established role in the transformation of normal cells to malignant cells. Case reports on a possible association between elevated growth hormone and cancer risk in a variety of patient groups have been published. Here, we describe clinical and laboratory findings for a patient with acromegaly who first developed thyroid cancer, and then, in the follow up period, probably due to poorly controlled insulin-like growth factor-1 levels, developed a large cell non-Hodgkin’s lymphoma. A search revealed that a case with these peculiarities had not previously been reported.