Integrated Assessment of GFAP and UCH-L1 for their utility in severity assessment and outcome prediction in Traumatic Brain Injury
- 08.07.2024
- Original Article
Erschienen in:
- Verfasst von
- Deepu Mathew
- Purvi Purohit
- Ashita Gadwal
- Abhishek Anil
- Raghavendra Kumar Sharma
- Vikas P. Meshram
- Puneet Setia
- Erschienen in
- International Journal of Legal Medicine | Ausgabe 6/2024
Abstract
Objectives
This study aimed to explore the potential of glial fibrillary acidic protein (GFAP) and ubiquitin C-terminal hydrolase-L1 (UCH-L1) as biomarkers for diagnosis and prognosis in mild and severe TBI cases, including TBI-related deaths.
Methods
This prospective cohort study includes 40 cases each of mild, severe, fatal TBI cases, and 40 healthy controls. Serum samples were collected from live patients at 8 and 20 h post injury for UCH-L1 and GFAP respectively, and from deceased patients within 6 h of death.
Results
Elevated levels of both GFAP and UCH-L1 were observed in patients with severe and fatal TBI cases. These biomarkers exhibited promising potential for predicting various Glasgow Outcome Scale Extended (GOSE) categories. Combining GFAP and UCH-L1 yielded higher predictive accuracy both for diagnosis and prognosis in TBI cases. The study additionally established specific cut-off levels for GFAP and UCH-L1 stratified according to the severity and prognosis.
Conclusion
GFAP and UCH-L1 individually demonstrated moderate to good discrimination capacity in predicting TBI severity and functional outcomes. However, combining these biomarkers is recommended for improved diagnostic and prognostic utility. This precision tool can enhance patient care, enabling tailored treatment plans, ultimately reducing morbidity and mortality rates in TBI cases.
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- Titel
- Integrated Assessment of GFAP and UCH-L1 for their utility in severity assessment and outcome prediction in Traumatic Brain Injury
- Verfasst von
-
Deepu Mathew
Purvi Purohit
Ashita Gadwal
Abhishek Anil
Raghavendra Kumar Sharma
Vikas P. Meshram
Puneet Setia
- Publikationsdatum
- 08.07.2024
- Verlag
- Springer Berlin Heidelberg
- Erschienen in
-
International Journal of Legal Medicine / Ausgabe 6/2024
Print ISSN: 0937-9827
Elektronische ISSN: 1437-1596 - DOI
- https://doi.org/10.1007/s00414-024-03287-z
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