Background
Methods
Data source and data preprocessing
DEG screening and hierarchical cluster analysis
Functional and pathway enrichment analysis
PPI network and module analyses
Integrated network analysis
Results
DEG analysis and hierarchical cluster analysis
Functional and pathway enrichment analysis
PPI network and module analyses
Gene | Degree | Betweenness | Closeness |
---|---|---|---|
Ms4a6d | 41.0 | 888.54470 | 0.055844676 |
Ly86 | 39.0 | 523.09924 | 0.055800000 |
Ms4a6b | 39.0 | 2949.2993 | 0.055755395 |
C1qb | 38.0 | 1383.42100 | 0.055766540 |
C1qa | 38.0 | 3947.00420 | 0.056295400 |
Aif1 | 37.0 | 4212.39100 | 0.056261342 |
Mpeg1 | 37.0 | 323.91983 | 0.055655297 |
Fcgr1 | 37.0 | 501.60864 | 0.055633100 |
Ctss | 37.0 | 640.59326 | 0.055588763 |
C1qc | 37.0 | 749.12880 | 0.055811163 |
Clec4a3 | 36.0 | 475.66116 | 0.055710863 |
Gpr65 | 36.0 | 998.11590 | 0.055822328 |
Igsf6 | 34.0 | 173.94502 | 0.055544496 |
Fcgr3 | 34.0 | 1279.76680 | 0.055811163 |
Cd86 | 33.0 | 2105.79080 | 0.055710863 |
Themis2 | 33.0 | 415.82825 | 0.055577688 |
Fcgr4 | 33.0 | 310.27353 | 0.055500300 |
Ms4a6c | 33.0 | 146.86868 | 0.055566620 |
Cybb | 33.0 | 5207.74660 | 0.056695793 |
Ccl6 | 32.0 | 927.98834 | 0.055721990 |
Clec4n | 31.0 | 164.47343 | 0.055555556 |
Category | Term | Count |
P value | Gene symbol |
---|---|---|---|---|
(A) | ||||
GO_BP | GO:0002376~immune system process | 8 | 1.63E−07 |
C1QA, C1QB, CD86, LY86, FCGR1, THEMIS2, C1QC, CLEC4N
|
GO:0045576~mast cell activation | 4 | 3.83E−07 |
CD48, FYB, FCGR2B, FCGR3
| |
GO:0045087~innate immune response | 7 | 4.62E−06 |
C1QA, C1QB, CYBB, LY86, FCGR1, C1QC, CLEC4N
| |
GO:0006911~phagocytosis, engulfment | 4 | 1.86E−05 |
FCGR2B, AIF1, FCGR1, FCGR3
| |
GO:0006954~inflammatory response | 5 | 5.96E−04 |
CYBB, AIF1, LY86, THEMIS2, CCL6
| |
PATHWAY | mmu05150:Staphylococcus aureus infection | 7 | 2.59E−10 |
C1QA, C1QB, FCGR2B, FCGR4, FCGR1, C1QC, FCGR3
|
mmu05322:Systemic lupus erythematosus | 6 | 6.02E−06 |
C1QA, C1QB, CD86, FCGR4, FCGR1, C1QC
| |
mmu04145:Phagosome | 6 | 1.37E−05 |
CYBB, FCGR2B, FCGR4, CTSS, FCGR1, FCGR3
| |
mmu05152:Tuberculosis | 6 | 1.45E−05 |
FCGR2B, IL10RA, FCGR4, CTSS, FCGR1, FCGR3
| |
mmu04380:Osteoclast differentiation | 5 | 8.03E−05 |
CYBB, FCGR2B, FCGR4, FCGR1, FCGR3
| |
(B) | ||||
GO_BP | GO:0016125~sterol metabolic process | 8 | 4.60E−14 |
CYP51, LDLR, HMGCR, FDPS, HMGCS1, SREBF2, SC4MOL, DHCR24
|
GO:0008202~steroid metabolic process | 9 | 5.23E−14 |
CYP51, LDLR, HMGCR, FDPS, HMGCS1, LSS, SREBF2, SC4MOL, DHCR24
| |
GO:0008203~cholesterol metabolic process | 7 | 6.80E−12 |
CYP51, LDLR, HMGCR, FDPS, HMGCS1, SREBF2, DHCR24
| |
GO:0006694~steroid biosynthetic process | 7 | 7.42E−12 |
CYP51, HMGCR, FDPS, HMGCS1, LSS, SC4MOL, DHCR24
| |
GO:0016126~sterol biosynthetic process | 6 | 1.69E−11 |
CYP51, HMGCR, FDPS, HMGCS1, SC4MOL, DHCR24
| |
PATHWAY | mmu00100:Steroid biosynthesis | 5 | 1.10E−08 |
CYP51, SQLE, LSS, SC4MOL, DHCR24
|
mmu00900:Terpenoid backbone biosynthesis | 3 | 2.46E−04 |
HMGCR, FDPS, HMGCS1
|