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Erschienen in: Clinical and Translational Oncology 7/2019

19.12.2018 | Review Article

Integrative diagnosis of cancer by combining CTCs and associated peripheral blood cells in liquid biopsy

verfasst von: W.-W. Zhang, Y. Rong, Q. Liu, C.-L. Luo, Y. Zhang, F.-B. Wang

Erschienen in: Clinical and Translational Oncology | Ausgabe 7/2019

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Abstract

Circulating tumor cells (CTCs), as cells shed from solid tumor into the vasculature, play a significant role in tumor metastasis. In the peripheral blood, immune cells and stromal cells can interact with CTCs and influence their biological behaviors of survival, proliferation, dissemination, and immune evasion. These peripheral blood cells can evolve synergistically with CTCs to constitute the liquid microenvironment which is essential for tumor progression. Here, we review the mechanisms of peripheral blood cells interacting with CTCs and uncover their effects on both CTCs and tumor metastasis. Then, we introduce the applications of these CTC-associated peripheral blood cells in the clinical setting. Besides, some peripheral blood cell subsets are of additional clinical values to CTCs in cancer diagnosis and prognosis. To improve the clinical utility of CTCs, an integrative analysis of CTCs and associated peripheral blood cells should be advocated for, which could provide a novel insight into tumor biology and offer comprehensive information in cancer diagnosis, prognosis, and therapy efficacy evaluation.
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Metadaten
Titel
Integrative diagnosis of cancer by combining CTCs and associated peripheral blood cells in liquid biopsy
verfasst von
W.-W. Zhang
Y. Rong
Q. Liu
C.-L. Luo
Y. Zhang
F.-B. Wang
Publikationsdatum
19.12.2018
Verlag
Springer International Publishing
Erschienen in
Clinical and Translational Oncology / Ausgabe 7/2019
Print ISSN: 1699-048X
Elektronische ISSN: 1699-3055
DOI
https://doi.org/10.1007/s12094-018-02004-8

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