Intensivmedizinische Studien aus 2016/2017

1.

Bone RC, Balk RA, Cerra FB, Dellinger RP, Fein AM, Knaus WA, Schein RM, Sibbald WJ (1992) Definitions for sepsis and organ failure and guidelines for the use of innovative therapies in sepsis. The ACCP/SCCM Consensus Conference Committee. American College of Chest Physicians/Society of Critical Care Medicine. Chest 101:1644–1655PubMedCrossRef

2.

Kaukonen KM, Bailey M, Pilcher D, Cooper DJ, Bellomo R (2015) Systemic inflammatory response syndrome criteria in defining severe sepsis. N Engl J Med 372:1629–1638PubMedCrossRef

3.

Singer M, Deutschman CS, Seymour CW, Shankar-Hari M, Annane D, Bauer M, Bellomo R, Bernard GR, Chiche JD, Coopersmith CM, Hotchkiss RS, Levy MM, Marshall JC, Martin GS, Opal SM, Rubenfeld GD, van der Poll T, Vincent JL, Angus DC (2016) The third international consensus definitions for sepsis and septic shock (sepsis-3). JAMA 315:801–810PubMedPubMedCentralCrossRef

4.

Seymour CW, Liu VX, Iwashyna TJ, Brunkhorst FM, Rea TD, Scherag A, Rubenfeld G, Kahn JM, Shankar-Hari M, Singer M, Deutschman CS, Escobar GJ, Angus DC (2016) Assessment of clinical criteria for sepsis: for the third international consensus definitions for sepsis and septic shock (sepsis-3). JAMA 315:762–774PubMedPubMedCentralCrossRef

5.

Shankar-Hari M, Phillips GS, Levy ML, Seymour CW, Liu VX, Deutschman CS, Angus DC, Rubenfeld GD, Singer M, Sepsis Definitions Task F (2016) Developing a new definition and assessing new clinical criteria for septic shock: For the third international consensus definitions for sepsis and septic shock (sepsis-3). JAMA 315:775–787PubMedPubMedCentralCrossRef

6.

Vincent JL, Martin GS, Levy MM (2016) qSOFA does not replace SIRS in the definition of sepsis. Crit Care 20:210PubMedPubMedCentralCrossRef

7.

SepNet Critical Care Trials G (2016) Incidence of severe sepsis and septic shock in German intensive care units: The prospective, multicentre INSEP study. Intensive Care Med 42:1980–1989CrossRef

8.

Rhodes A, Evans LE, Alhazzani W, Levy MM, Antonelli M, Ferrer R, Kumar A, Sevransky JE, Sprung CL, Nunnally ME, Rochwerg B, Rubenfeld GD, Angus DC, Annane D, Beale RJ, Bellinghan GJ, Bernard GR, Chiche JD, Coopersmith C, De Backer DP, French CJ, Fujishima S, Gerlach H, Hidalgo JL, Hollenberg SM, Jones AE, Karnad DR, Kleinpell RM, Koh Y, Lisboa TC, Machado FR, Marini JJ, Marshall JC, Mazuski JE, McIntyre LA, McLean AS, Mehta S, Moreno RP, Myburgh J, Navalesi P, Nishida O, Osborn TM, Perner A, Plunkett CM, Ranieri M, Schorr CA, Seckel MA, Seymour CW, Shieh L, Shukri KA, Simpson SQ, Singer M, Thompson BT, Townsend SR, Van der Poll T, Vincent JL, Wiersinga WJ, Zimmerman JL, Dellinger RP (2017) Surviving sepsis campaign: international guidelines for management of sepsis and septic shock: 2016. Crit Care Med 45:486–552. doi:10.1097/CCM.0000000000002255 PubMedCrossRef

9.

Leisman D, Wie B, Doerfler M, Bianculli A, Ward MF, Akerman M, D’Angelo JK, Zemmel D’Amore JA (2016) Association of fluid resuscitation initiation within 30 minutes of severe sepsis and septic shock recognition with reduced mortality and length of stay. Ann Emerg Med 68:298–311PubMedCrossRef

10.

Raith EP, Udy AA, Bailey M, McGloughlin S, MacIsaac C, Bellomo R, Pilcher DV, Australian, New Zealand Intensive Care Society Centre for O, Resource E (2017) Prognostic accuracy of the SOFA score, SIRS criteria, and qSOFA score for in-hospital mortality among adults with suspected infection admitted to the intensive care unit. JAMA 317:290–300PubMedCrossRef

11.

Freund Y, Lemachatti N, Krastinova E, Van Laer M, Claessens YE, Avondo A, Occelli C, Feral-Pierssens AL, Truchot J, Ortega M, Carneiro B, Pernet J, Claret PG, Dami F, Bloom B, Riou B, Beaune S, French Society of Emergency Medicine Collaborators G (2017) Prognostic accuracy of sepsis-3 criteria for in-hospital mortality among patients with suspected infection presenting to the emergency department. JAMA 317:301–308PubMedCrossRef

12.

Williams JM, Greenslade JH, McKenzie JV, Chu K, Brown AF, Lipman J (2016) SIRS, qSOFA and organ dysfunction: insights from a prospective database of emergency department patients with infection. Chest 151(3):586–596. doi:10.1016/j.chest.2016.10.057 PubMedCrossRef

13.

Churpek MM, Snyder A, Han X, Sokol S, Pettit N, Howell MD, Edelson DP (2016) qSOFA, SIRS, and early warning scores for detecting clinical deterioration in infected patients outside the ICU. Am J Respir Crit Care Med 195(7):906–911. doi:10.1164/rccm.201604-0854OC CrossRef

14.

Singer AJ, Ng J, Thode HC Jr., Spiegel R, Weingart S (2017) Quick SOFA scores predict mortality in adult emergency department patients with and without suspected infection. Ann Emerg Med 69(4):475–479. doi:10.1016/j.annemergmed.2016.10.007 PubMedCrossRef

15.

Giamarellos-Bourboulis EJ, Tsaganos T, Tsangaris I, Lada M, Routsi C, Sinapidis D, Koupetori M, Bristianou M, Adamis G, Mandragos K, Dalekos GN, Kritselis I, Giannikopoulos G, Koutelidakis I, Pavlaki M, Antoniadou E, Vlachogiannis G, Koulouras V, Prekates A, Dimopoulos G, Koutsoukou A, Pnevmatikos I, Ioakeimidou A, Kotanidou A, Orfanos SE, Armaganidis A, Gogos C, Hellenic Sepsis Study G (2017) Validation of the new Sepsis-3 definitions: Proposal for improvement in early risk identification. Clin Microbiol Infect 23:104–109PubMedCrossRef

16.

Wang JY, Chen YX, Guo SB, Mei X, Yang P (2016) Predictive performance of quick sepsis-related organ failure assessment for mortality and ICU admission in patients with infection at the ED. Am J Emerg Med 34:1788–1793PubMedCrossRef

17.

Dellinger RP, Schorr CA, Levy MM (2017) A users’ guide to the 2016 surviving sepsis guidelines. Crit Care Med 45(3):381–385. doi:10.1097/CCM.0000000000002257 PubMedCrossRef

18.

Howell MD, Davis AM (2017) Management of Sepsis and Septic Shock. JAMA 317(8):847–848. doi:10.1001/jama.2017.0131 PubMedCrossRef

19.

De Backer D, Dorman T (2017) Surviving sepsis guidelines: A continuous move toward better care of patients with sepsis. JAMA 317(8):807–808. doi:10.1001/jama.2017.0059 PubMedCrossRef

20.

Dellinger RP, Levy MM, Rhodes A, Annane D, Gerlach H, Opal SM, Sevransky JE, Sprung CL, Douglas IS, Jaeschke R, Osborn TM, Nunnally ME, Townsend SR, Reinhart K, Kleinpell RM, Angus DC, Deutschman CS, Machado FR, Rubenfeld GD, Webb SA, Beale RJ, Vincent JL, Moreno R, Surviving Sepsis Campaign Guidelines Committee including the Pediatric (2013) Surviving sepsis campaign: international guidelines for management of severe sepsis and septic shock: 2012. Crit Care Med 41:580–637PubMedCrossRef

21.

Mouncey PR, Osborn TM, Power GS, Harrison DA, Sadique MZ, Grieve RD, Jahan R, Harvey SE, Bell D, Bion JF, Coats TJ, Singer M, Young JD, Rowan KM, Pro MTI (2015) Trial of early, goal-directed resuscitation for septic shock. N Engl J Med 372:1301–1311PubMedCrossRef

22.

Peake SL, Delaney A, Bailey M, Bellomo R, Cameron PA, Cooper DJ, Higgins AM, Holdgate A, Howe BD, Webb SA, Williams P (2014) Goal-directed resuscitation for patients with early septic shock. N Engl J Med 371:1496–1506PubMedCrossRef

23.

Yealy DM, Kellum JA, Huang DT, Barnato AE, Weissfeld LA, Pike F, Terndrup T, Wang HE, Hou PC, LoVecchio F, Filbin MR, Shapiro NI, Angus DC (2014) A randomized trial of protocol-based care for early septic shock. N Engl J Med 370:1683–1693PubMedCrossRef

24.

Allegranzi B, Bischoff P, de Jonge S, Kubilay NZ, Zayed B, Gomes SM, Abbas M, Atema JJ, Gans S, van Rijen M, Boermeester MA, Egger M, Kluytmans J, Pittet D, Solomkin JS, Group WHOGD (2016) New WHO recommendations on preoperative measures for surgical site infection prevention: An evidence-based global perspective. Lancet Infect Dis 16:e276–e287PubMedCrossRef

25.

Allegranzi B, Zayed B, Bischoff P, Kubilay NZ, de Jonge S, de Vries F, Gomes SM, Gans S, Wallert ED, Wu X, Abbas M, Boermeester MA, Dellinger EP, Egger M, Gastmeier P, Guirao X, Ren J, Pittet D, Solomkin JS, Group WHOGD (2016) New WHO recommendations on intraoperative and postoperative measures for surgical site infection prevention: An evidence-based global perspective. Lancet Infect Dis 16:e288–e303PubMedCrossRef

26.

Anderson DJ, Podgorny K, Berrios-Torres SI, Bratzler DW, Dellinger EP, Greene L, Nyquist AC, Saiman L, Yokoe DS, Maragakis LL, Kaye KS (2014) Strategies to prevent surgical site infections in acute care hospitals: 2014 update. Infect Control Hosp Epidemiol 35:605–627PubMedPubMedCentralCrossRef

27.

Pryor KO, Fahey TJ 3rd, Lien CA, Goldstein PA (2004) Surgical site infection and the routine use of perioperative hyperoxia in a general surgical population: A randomized controlled trial. JAMA 291:79–87PubMedCrossRef

28.

Meyhoff CS, Wetterslev J, Jorgensen LN, Henneberg SW, Hogdall C, Lundvall L, Svendsen PE, Mollerup H, Lunn TH, Simonsen I, Martinsen KR, Pulawska T, Bundgaard L, Bugge L, Hansen EG, Riber C, Gocht-Jensen P, Walker LR, Bendtsen A, Johansson G, Skovgaard N, Helto K, Poukinski A, Korshin A, Walli A, Bulut M, Carlsson PS, Rodt SA, Lundbech LB, Rask H, Buch N, Perdawid SK, Reza J, Jensen KV, Carlsen CG, Jensen FS, Rasmussen LS, Group PT (2009) Effect of high perioperative oxygen fraction on surgical site infection and pulmonary complications after abdominal surgery: The PROXI randomized clinical trial. JAMA 302:1543–1550PubMedCrossRef

29.

Meyhoff CS, Jorgensen LN, Wetterslev J, Christensen KB, Rasmussen LS, Group PT (2012) Increased long-term mortality after a high perioperative inspiratory oxygen fraction during abdominal surgery: Follow-up of a randomized clinical trial. Anesth Analg 115:849–854PubMedCrossRef

30.

Volk T, Peters J, Sessler DI (2017) The WHO recommendation for 80 % perioperative oxygen is poorly justified. Anaesthesist 66(4):227–229. doi:10.1007/s00101-017-0286-4 PubMedCrossRef

31.

Abdul-Aziz MH, Sulaiman H, Mat-Nor MB, Rai V, Wong KK, Hasan MS, Abd Rahman AN, Jamal JA, Wallis SC, Lipman J, Staatz CE, Roberts JA (2016) Beta-Lactam Infusion in Severe Sepsis (BLISS): A prospective, two-centre, open-labelled randomised controlled trial of continuous versus intermittent beta-lactam infusion in critically ill patients with severe sepsis. Intensive Care Med 42(10):1535–1545. doi:10.1007/s00134-015-4188-0 PubMedCrossRef

32.

Dulhunty JM, Roberts JA, Davis JS, Webb SA, Bellomo R, Gomersall C, Shirwadkar C, Eastwood GM, Myburgh J, Paterson DL, Starr T, Paul SK, Lipman J, BIIft ACT (2015) A multicenter randomized trial of continuous versus intermittent beta-Lactam infusion in severe sepsis. Am J Respir Crit Care Med 192:1298–1305PubMedCrossRef

33.

Falagas ME, Tansarli GS, Ikawa K, Vardakas KZ (2013) Clinical outcomes with extended or continuous versus short-term intravenous infusion of carbapenems and piperacillin/tazobactam: A systematic review and meta-analysis. Clin Infect Dis 56:272–282PubMedCrossRef

34.

Roberts JA, Abdul-Aziz MH, Davis JS, Dulhunty JM, Cotta MO, Myburgh J, Bellomo R, Lipman J (2016) Continuous versus intermittent beta-Lactam infusion in severe sepsis. A meta-analysis of individual patient data from randomized trials. Am J Respir Crit Care Med 194:681–691PubMedCrossRef

35.

Osthoff M, Siegemund M, Balestra G, Abdul-Aziz MH, Roberts JA (2016) Prolonged administration of beta-lactam antibiotics – a comprehensive review and critical appraisal. Swiss Med Wkly 146:w14368PubMed

36.

de Jong E, van Oers JA, Beishuizen A, Vos P, Vermeijden WJ, Haas LE, Loef BG, Dormans T, van Melsen GC, Kluiters YC, Kemperman H, van den Elsen MJ, Schouten JA, Streefkerk JO, Krabbe HG, Kieft H, Kluge GH, van Dam VC, van Pelt J, Bormans L, Otten MB, Reidinga AC, Endeman H, Twisk JW, van de Garde EM, de Smet AM, Kesecioglu J, Girbes AR, Nijsten MW, de Lange DW (2016) Efficacy and safety of procalcitonin guidance in reducing the duration of antibiotic treatment in critically ill patients: a randomised, controlled, open-label trial. Lancet Infect Dis 16(7):819–827. doi:10.1016/S1473-3099(16)00053-0 PubMedCrossRef

37.

Bloos F, Trips E, Nierhaus A, Briegel J, Heyland DK, Jaschinski U, Moerer O, Weyland A, Marx G, Grundling M, Kluge S, Kaufmann I, Ott K, Quintel M, Jelschen F, Meybohm P, Rademacher S, Meier-Hellmann A, Utzolino S, Kaisers UX, Putensen C, Elke G, Ragaller M, Gerlach H, Ludewig K, Kiehntopf M, Bogatsch H, Engel C, Brunkhorst FM, Loeffler M, Reinhart K, for SepNet Critical Care Trials G (2016) Effect of sodium selenite administration and Procalcitonin-guided therapy on mortality in patients with severe sepsis or septic shock: A randomized clinical trial. JAMA Intern Med 176:1266–1276PubMedCrossRef

38.

Zangrillo A, Putzu A, Monaco F, Oriani A, Frau G, De Luca M, Di Tomasso N, Bignami E, Lomivorotov V, Likhvantsev V, Landoni G (2015) Levosimendan reduces mortality in patients with severe sepsis and septic shock: A meta-analysis of randomized trials. J Crit Care 30:908–913PubMedCrossRef

39.

Gordon AC, Perkins GD, Singer M, McAuley DF, Orme RM, Santhakumaran S, Mason AJ, Cross M, Al-Beidh F, Best-Lane J, Brealey D, Nutt CL, McNamee JJ, Reschreiter H, Breen A, Liu KD, Ashby D (2016) Levosimendan for the prevention of acute organ dysfunction in sepsis. N Engl J Med 375:1638–1648PubMedCrossRef

40.

Keh D, Trips E, Marx G, Wirtz SP, Abduljawwad E, Bercker S, Bogatsch H, Briegel J, Engel C, Gerlach H, Goldmann A, Kuhn SO, Huter L, Meier-Hellmann A, Nierhaus A, Kluge S, Lehmke J, Loeffler M, Oppert M, Resener K, Schadler D, Schuerholz T, Simon P, Weiler N, Weyland A, Reinhart K, Brunkhorst FM, SepNet-Critical Care Trials G (2016) Effect of Hydrocortisone on development of shock among patients with severe sepsis: The HYPRESS randomized clinical trial. JAMA 316:1775–1785PubMedCrossRef

41.

Sprung CL, Annane D, Keh D, Moreno R, Singer M, Freivogel K, Weiss YG, Benbenishty J, Kalenka A, Forst H, Laterre PF, Reinhart K, Cuthbertson BH, Payen D, Briegel J, Group CS (2008) Hydrocortisone therapy for patients with septic shock. N Engl J Med 358:111–124PubMedCrossRef

42.

Ashbaugh DG, Bigelow DB, Petty TL, Levine BE (1967) Acute respiratory distress in adults. Lancet 2:319–323PubMedCrossRef

43.

Bellani G, Laffey JG, Pham T, Fan E, Brochard L, Esteban A, Gattinoni L, van Haren F, Larsson A, McAuley DF, Ranieri M, Rubenfeld G, Thompson BT, Wrigge H, Slutsky AS, Pesenti A, Investigators LS, Group ET (2016) Epidemiology, patterns of care, and mortality for patients with acute respiratory distress syndrome in intensive care units in 50 countries. JAMA 315:788–800PubMedCrossRef

44.

Ranieri VM, Rubenfeld GD, Thompson BT, Ferguson ND, Caldwell E, Fan E, Camporota L, Slutsky AS (2012) Acute respiratory distress syndrome: The Berlin Definition. JAMA 307:2526–2533PubMed

45.

Laffey JG, Bellani G, Pham T, Fan E, Madotto F, Bajwa EK, Brochard L, Clarkson K, Esteban A, Gattinoni L, van Haren F, Heunks LM, Kurahashi K, Laake JH, Larsson A, McAuley DF, McNamee L, Nin N, Qiu H, Ranieri M, Rubenfeld GD, Thompson BT, Wrigge H, Slutsky AS, Pesenti A, Investigators LS, the ETG (2016) Potentially modifiable factors contributing to outcome from acute respiratory distress syndrome: the LUNG SAFE study. Intensive Care Med 42:1865–1876PubMedCrossRef

46.

Bellani G, Laffey JG, Pham T, Madotto F, Fan E, Brochard L, Esteban A, Gattinoni L, Bumbasirevic V, Piquilloud L, van Haren F, Larsson A, McAuley DF, Bauer PR, Arabi YM, Ranieri M, Antonelli M, Rubenfeld GD, Thompson BT, Wrigge H, Slutsky AS, Pesenti A, Investigators LS, Group ET (2017) Noninvasive ventilation of patients with acute respiratory distress syndrome. Insights from the LUNG SAFE study. Am J Respir Crit Care Med 195:67–77PubMedCrossRef

47.

Bein T, Grasso S, Moerer O, Quintel M, Guerin C, Deja M, Brondani A, Mehta S (2016) The standard of care of patients with ARDS: Ventilatory settings and rescue therapies for refractory hypoxemia. Intensive Care Med 42:699–711PubMedPubMedCentralCrossRef

48.

Stub D, Smith K, Bernard S, Nehme Z, Stephenson M, Bray JE, Cameron P, Barger B, Ellims AH, Taylor AJ, Meredith IT, Kaye DM, Investigators A (2015) Air Versus Oxygen in ST-Segment-Elevation Myocardial Infarction. Circulation 131:2143–2150PubMedCrossRef

49.

Girardis M, Busani S, Damiani E, Donati A, Rinaldi L, Marudi A, Morelli A, Antonelli M, Singer M (2016) Effect of conservative vs conventional oxygen therapy on mortality among patients in an intensive care unit: The oxygen-ICU randomized clinical trial. JAMA 316:1583–1589PubMedCrossRef

50.

Frat JP, Thille AW, Mercat A, Girault C, Ragot S, Perbet S, Prat G, Boulain T, Morawiec E, Cottereau A, Devaquet J, Nseir S, Razazi K, Mira JP, Argaud L, Chakarian JC, Ricard JD, Wittebole X, Chevalier S, Herbland A, Fartoukh M, Constantin JM, Tonnelier JM, Pierrot M, Mathonnet A, Beduneau G, Deletage-Metreau C, Richard JC, Brochard L, Robert R, Group FS, Network R (2015) High-flow oxygen through nasal cannula in acute hypoxemic respiratory failure. N Engl J Med 372:2185–2196PubMedCrossRef

51.

Hernandez G, Vaquero C, Gonzalez P, Subira C, Frutos-Vivar F, Rialp G, Laborda C, Colinas L, Cuena R, Fernandez R (2016) Effect of Postextubation high-flow nasal cannula vs conventional oxygen therapy on Reintubation in low-risk patients: A randomized clinical trial. JAMA 315(13):1354–1361. doi: 10.1001/jama.2016.2711 PubMedCrossRef

52.

Reuss CJ, Bernhard M, Beynon C, Hofer S, Jungk C, Michalski D, Weigand MA, Brenner T (2016) Intensive care studies from 2015/2016. Anaesthesist 65:532–552PubMedCrossRef

53.

Jaber S, Monnin M, Girard M, Conseil M, Cisse M, Carr J, Mahul M, Delay JM, Belafia F, Chanques G, Molinari N, De Jong A (2016) Apnoeic oxygenation via high-flow nasal cannula oxygen combined with non-invasive ventilation preoxygenation for intubation in hypoxaemic patients in the intensive care unit: the single-centre, blinded, randomised controlled OPTINIV trial. Intensive Care Med 42:1877–1887PubMedCrossRef

54.

Hernandez G, Vaquero C, Colinas L, Cuena R, Gonzalez P, Canabal A, Sanchez S, Rodriguez ML, Villasclaras A, Fernandez R (2016) Effect of Postextubation high-flow nasal cannula vs Noninvasive ventilation on Reintubation and Postextubation respiratory failure in high-risk patients: A randomized clinical trial. JAMA 316:1565–1574PubMedCrossRef

55.

Patel BK, Wolfe KS, Pohlman AS, Hall JB, Kress JP (2016) Effect of Noninvasive ventilation delivered by helmet vs face mask on the rate of Endotracheal Intubation in patients with acute respiratory distress syndrome: A randomized clinical trial. JAMA 315:2435–2441PubMedPubMedCentralCrossRef

56.

Hoste EA, Bagshaw SM, Bellomo R, Cely CM, Colman R, Cruz DN, Edipidis K, Forni LG, Gomersall CD, Govil D, Honore PM, Joannes-Boyau O, Joannidis M, Korhonen AM, Lavrentieva A, Mehta RL, Palevsky P, Roessler E, Ronco C, Uchino S, Vazquez JA, Andrade VE, Webb S, Kellum JA (2015) Epidemiology of acute kidney injury in critically ill patients: The multinational AKI-EPI study. Intensive Care Med 41:1411–1423PubMedCrossRef

57.

Bellomo R, Ronco C, Kellum JA, Mehta RL, Palevsky P, Acute Dialysis Quality Initiative w (2004) Acute renal failure – definition, outcome measures, animal models, fluid therapy and information technology needs: The second international consensus conference of the acute dialysis quality initiative (ADQI) group. Crit Care 8:R204–212PubMedPubMedCentralCrossRef

58.

Khwaja A (2012) KDIGO clinical practice guidelines for acute kidney injury. Nephron Clin Pract 120:c179–c184PubMed

59.

Izawa J, Uchino S, Takinami M (2016) A detailed evaluation of the new acute kidney injury criteria by KDIGO in critically ill patients. J Anesth 30:215–222PubMedCrossRef

60.

Gaudry S, Hajage D, Schortgen F, Martin-Lefevre L, Pons B, Boulet E, Boyer A, Chevrel G, Lerolle N, Carpentier D, de Prost N, Lautrette A, Bretagnol A, Mayaux J, Nseir S, Megarbane B, Thirion M, Forel JM, Maizel J, Yonis H, Markowicz P, Thiery G, Tubach F, Ricard JD, Dreyfuss D, Group AS (2016) Initiation strategies for renal-replacement therapy in the intensive care unit. N Engl J Med 375:122–133PubMedCrossRef

61.

Zarbock A, Kellum JA, Schmidt C, Van Aken H, Wempe C, Pavenstadt H, Boanta A, Gerss J, Meersch M (2016) Effect of early vs delayed initiation of renal replacement therapy on mortality in critically ill patients with acute kidney injury: The ELAIN randomized clinical trial. JAMA 315:2190–2199PubMedCrossRef

62.

Zhang L, Chen Z, Diao Y, Yang Y, Fu P (2015) Associations of fluid overload with mortality and kidney recovery in patients with acute kidney injury: A systematic review and meta-analysis. J Crit Care 30:e867–813

63.

Kimmel M, Shi J, Latus J, Wasser C, Kitterer D, Braun N, Alscher MD (2016) Association of renal stress/damage and filtration Biomarkers with subsequent AKI during hospitalization among patients presenting to the emergency department. Clin J Am Soc Nephrol 11:938–946PubMedPubMedCentralCrossRef

64.

Banares R, Nevens F, Larsen FS, Jalan R, Albillos A, Dollinger M, Saliba F, Sauerbruch T, Klammt S, Ockenga J, Pares A, Wendon J, Brunnler T, Kramer L, Mathurin P, de la Mata M, Gasbarrini A, Mullhaupt B, Wilmer A, Laleman W, Eefsen M, Sen S, Zipprich A, Tenorio T, Pavesi M, Schmidt HH, Mitzner S, Williams R, Arroyo V, group Rs (2013) Extracorporeal albumin dialysis with the molecular adsorbent recirculating system in acute-on-chronic liver failure: The RELIEF trial. Hepatology 57:1153–1162PubMedCrossRef

65.

Kribben A, Gerken G, Haag S, Herget-Rosenthal S, Treichel U, Betz C, Sarrazin C, Hoste E, Van Vlierberghe H, Escorsell A, Hafer C, Schreiner O, Galle PR, Mancini E, Caraceni P, Karvellas CJ, Salmhofer H, Knotek M, Gines P, Kozik-Jaromin J, Rifai K, Group HS (2012) Effects of fractionated plasma separation and adsorption on survival in patients with acute-on-chronic liver failure. Gastroenterology 142:782–789PubMedCrossRef

66.

Larsen FS, Schmidt LE, Bernsmeier C, Rasmussen A, Isoniemi H, Patel VC, Triantafyllou E, Bernal W, Auzinger G, Shawcross D, Eefsen M, Bjerring PN, Clemmesen JO, Hockerstedt K, Frederiksen HJ, Hansen BA, Antoniades CG, Wendon J (2016) High-volume plasma exchange in patients with acute liver failure: An open randomised controlled trial. J Hepatol 64:69–78PubMedCrossRef

67.

Ferenci P, Lockwood A, Mullen K, Tarter R, Weissenborn K, Blei AT (2002) Hepatic encephalopathy – definition, nomenclature, diagnosis, and quantification: final report of the working party at the 11th World Congresses of Gastroenterology, Vienna, 1998. Hepatology 35:716–721PubMedCrossRef

68.

Dalton JE, Kurz A, Turan A, Mascha EJ, Sessler DI, Saager L (2011) Development and validation of a risk quantification index for 30-day postoperative mortality and morbidity in noncardiac surgical patients. Anesthesiology 114:1336–1344PubMedCrossRef

69.

Morris PE, Goad A, Thompson C, Taylor K, Harry B, Passmore L, Ross A, Anderson L, Baker S, Sanchez M, Penley L, Howard A, Dixon L, Leach S, Small R, Hite RD, Haponik E (2008) Early intensive care unit mobility therapy in the treatment of acute respiratory failure. Crit Care Med 36:2238–2243PubMedCrossRef

70.

Needham DM, Korupolu R, Zanni JM, Pradhan P, Colantuoni E, Palmer JB, Brower RG, Fan E (2010) Early physical medicine and rehabilitation for patients with acute respiratory failure: A quality improvement project. Arch Phys Med Rehabil 91:536–542PubMedCrossRef

71.

Bein T, Bischoff M, Bruckner U, Gebhardt K, Henzler D, Hermes C, Lewandowski K, Max M, Nothacker M, Staudinger T, Tryba M, Weber-Carstens S, Wrigge H (2015) S2e guideline: positioning and early mobilisation in prophylaxis or therapy of pulmonary disorders : Revision 2015: S2e guideline of the German Society of Anaesthesiology and Intensive Care Medicine (DGAI). Anaesthesist 64(Suppl 1):1–26PubMedPubMedCentralCrossRef

72.

Schaller SJ, Anstey M, Blobner M, Edrich T, Grabitz SD, Gradwohl-Matis I, Heim M, Houle T, Kurth T, Latronico N, Lee J, Meyer MJ, Peponis T, Talmor D, Velmahos GC, Waak K, Walz JM, Zafonte R, Eikermann M, International Early S‑gMRI (2016) Early, goal-directed mobilisation in the surgical intensive care unit: A randomised controlled trial. Lancet 388:1377–1388PubMedCrossRef

73.

Kasotakis G, Schmidt U, Perry D, Grosse-Sundrup M, Benjamin J, Ryan C, Tully S, Hirschberg R, Waak K, Velmahos G, Bittner EA, Zafonte R, Cobb JP, Eikermann M (2012) The surgical intensive care unit optimal mobility score predicts mortality and length of stay. Crit Care Med 40:1122–1128PubMedCrossRef

74.

Piva S, Dora G, Minelli C, Michelini M, Turla F, Mazza S, D’Ottavi P, Moreno-Duarte I, Sottini C, Eikermann M, Latronico N (2015) The surgical optimal mobility score predicts mortality and length of stay in an italian population of medical, surgical, and neurologic intensive care unit patients. J Crit Care 30:1251–1257PubMedCrossRef

75.

Schaller SJ, Stauble CG, Suemasa M, Heim M, Duarte IM, Mensch O, Bogdanski R, Lewald H, Eikermann M, Blobner M (2016) The German validation study of the surgical intensive care unit optimal mobility score. J Crit Care 32:201–206PubMedCrossRef

76.

Meyer MJ, Stanislaus AB, Lee J, Waak K, Ryan C, Saxena R, Ball S, Schmidt U, Poon T, Piva S, Walz M, Talmor DS, Blobner M, Latronico N, Eikermann M (2013) Surgical Intensive Care Unit Optimal Mobilisation Score (SOMS) trial: A protocol for an international, multicentre, randomised controlled trial focused on goal-directed early mobilisation of surgical ICU patients. BMJ Open 3:e003262PubMedPubMedCentralCrossRef

77.

Juttler E, Unterberg A, Woitzik J, Bosel J, Amiri H, Sakowitz OW, Gondan M, Schiller P, Limprecht R, Luntz S, Schneider H, Pinzer T, Hobohm C, Meixensberger J, Hacke W, Investigators DI (2014) Hemicraniectomy in older patients with extensive middle-cerebral-artery stroke. N Engl J Med 370:1091–1100PubMedCrossRef

78.

Hutchinson PJ, Kolias AG, Timofeev IS, Corteen EA, Czosnyka M, Timothy J, Anderson I, Bulters DO, Belli A, Eynon CA, Wadley J, Mendelow AD, Mitchell PM, Wilson MH, Critchley G, Sahuquillo J, Unterberg A, Servadei F, Teasdale GM, Pickard JD, Menon DK, Murray GD, Kirkpatrick PJ, Collaborators RET (2016) Trial of decompressive Craniectomy for traumatic Intracranial hypertension. N Engl J Med 375:1119–1130PubMedCrossRef

79.

Cooper DJ, Rosenfeld JV, Murray L, Arabi YM, Davies AR, D’Urso P, Kossmann T, Ponsford J, Seppelt I, Reilly P, Wolfe R, Investigators DT, Australian, New Zealand Intensive Care Society Clinical Trials G (2011) Decompressive craniectomy in diffuse traumatic brain injury. N Engl J Med 364:1493–1502PubMedCrossRef

80.

Antithrombotic Trialists C, Baigent C, Blackwell L, Collins R, Emberson J, Godwin J, Peto R, Buring J, Hennekens C, Kearney P, Meade T, Patrono C, Roncaglioni MC, Zanchetti A (2009) Aspirin in the primary and secondary prevention of vascular disease: Collaborative meta-analysis of individual participant data from randomised trials. Lancet 373:1849–1860CrossRef

81.

Naidech AM, Jovanovic B, Liebling S, Garg RK, Bassin SL, Bendok BR, Bernstein RA, Alberts MJ, Batjer HH (2009) Reduced platelet activity is associated with early clot growth and worse 3‑month outcome after intracerebral hemorrhage. Stroke 40:2398–2401PubMedCrossRef

82.

Baharoglu MI, Cordonnier C, Al-Shahi Salman R, de Gans K, Koopman MM, Brand A, Majoie CB, Beenen LF, Marquering HA, Vermeulen M, Nederkoorn PJ, de Haan RJ, Roos YB, Investigators P (2016) Platelet transfusion versus standard care after acute stroke due to spontaneous cerebral haemorrhage associated with antiplatelet therapy (PATCH): a randomised, open-label, phase 3 trial. Lancet 387:2605–2613PubMedCrossRef

83.

Batchelor JS, Grayson A (2012) A meta-analysis to determine the effect on survival of platelet transfusions in patients with either spontaneous or traumatic antiplatelet medication-associated intracranial haemorrhage. BMJ Open 2:e000588PubMedPubMedCentralCrossRef

84.

Hansen BM, Morgan TC, Betz JF, Sundgren PC, Norrving B, Hanley DF, Lindgren A (2016) Intraventricular extension of supratentorial Intracerebral hemorrhage: The modified Graeb scale improves outcome prediction in Lund stroke register. Neuroepidemiology 46:43–50PubMedCrossRef

85.

Naff N, Williams MA, Keyl PM, Tuhrim S, Bullock MR, Mayer SA, Coplin W, Narayan R, Haines S, Cruz-Flores S, Zuccarello M, Brock D, Awad I, Ziai WC, Marmarou A, Rhoney D, McBee N, Lane K, Hanley DF Jr. (2011) Low-dose recombinant tissue-type plasminogen activator enhances clot resolution in brain hemorrhage: The intraventricular hemorrhage thrombolysis trial. Stroke 42:3009–3016PubMedPubMedCentralCrossRef

86.

Hanley DF, Lane K, McBee N, Ziai W, Tuhrim S, Lees KR, Dawson J, Gandhi D, Ullman N, Mould WA, Mayo SW, Mendelow AD, Gregson B, Butcher K, Vespa P, Wright DW, Kase CS, Carhuapoma JR, Keyl PM, Diener-West M, Muschelli J, Betz JF, Thompson CB, Sugar EA, Yenokyan G, Janis S, John S, Harnof S, Lopez GA, Aldrich EF, Harrigan MR, Ansari S, Jallo J, Caron JL, LeDoux D, Adeoye O, Zuccarello M, Adams HP Jr., Rosenblum M, Thompson RE, Awad IA, Investigators CI (2017) Thrombolytic removal of intraventricular haemorrhage in treatment of severe stroke: Results of the randomised, multicentre, multiregion, placebo-controlled CLEAR III trial. Lancet 389:603–611PubMedCrossRef

87.

Steiner T, Poli S, Griebe M, Husing J, Hajda J, Freiberger A, Bendszus M, Bosel J, Christensen H, Dohmen C, Hennerici M, Kollmer J, Stetefeld H, Wartenberg KE, Weimar C, Hacke W, Veltkamp R (2016) Fresh frozen plasma versus prothrombin complex concentrate in patients with intracranial haemorrhage related to vitamin K antagonists (INCH): A randomised trial. Lancet Neurol 15:566–573PubMedCrossRef

88.

Anderson CS, Heeley E, Huang Y, Wang J, Stapf C, Delcourt C, Lindley R, Robinson T, Lavados P, Neal B, Hata J, Arima H, Parsons M, Li Y, Wang J, Heritier S, Li Q, Woodward M, Simes RJ, Davis SM, Chalmers J, Investigators I (2013) Rapid blood-pressure lowering in patients with acute intracerebral hemorrhage. N Engl J Med 368:2355–2365PubMedCrossRef

89.

Qureshi AI, Palesch YY, Martin R, Novitzke J, Cruz-Flores S, Ehtisham A, Ezzeddine MA, Goldstein JN, Hussein HM, Suri MF, Tariq N, Antihypertensive Treatment of Acute Cerebral Hemorrhage Study I (2010) Effect of systolic blood pressure reduction on hematoma expansion, perihematomal edema, and 3‑month outcome among patients with intracerebral hemorrhage: Results from the antihypertensive treatment of acute cerebral hemorrhage study. Arch Neurol 67:570–576PubMedPubMedCentralCrossRef

90.

Qureshi AI, Palesch YY, Barsan WG, Hanley DF, Hsu CY, Martin RL, Moy CS, Silbergleit R, Steiner T, Suarez JI, Toyoda K, Wang Y, Yamamoto H, Yoon BW, Investigators A‑T, the Neurological Emergency Treatment Trials N (2016) Intensive blood-pressure lowering in patients with acute cerebral hemorrhage. N Engl J Med 375:1033–1043PubMedPubMedCentralCrossRef

91.

Pfister HW, Bühler R, Eiffert H, Grabein B, Klein M, Linn J, Nau R, Salzberger B, Tumani H, Weber JR (2015) S2k-Leitlinie Ambulant erworbene bakterielle (eitrige) Meningoenzephalitis im Erwachsenenalter. Leitlinien für Diagnostik und Therapie in der Neurologie

92.

Brouwer MC, McIntyre P, Prasad K, van de Beek D (2015) Corticosteroids for acute bacterial meningitis. Cochrane Database Syst Rev 12(9):CD004405. doi:10.1002/14651858.CD004405.pub5

93.

Martinez-Torres F, Menon S, Pritsch M, Victor N, Jenetzky E, Jensen K, Schielke E, Schmutzhard E, de Gans J, Chung CH, Luntz S, Hacke W, Meyding-Lamade U, Investigators G (2008) Protocol for German trial of Acyclovir and corticosteroids in Herpes-simplex-virus-encephalitis (GACHE): a multicenter, multinational, randomized, double-blind, placebo-controlled German, Austrian and Dutch trial [ISRCTN45122933. BMC Neurol 8:40PubMedPubMedCentralCrossRef

94.

Ramos-Estebanez C, Lizarraga KJ, Merenda A (2014) A systematic review on the role of adjunctive corticosteroids in herpes simplex virus encephalitis: Is timing critical for safety and efficacy? Antivir Ther (Lond) 19:133–139CrossRef

95.

Beardsley J, Wolbers M, Kibengo FM, Ggayi AB, Kamali A, Cuc NT, Binh TQ, Chau NV, Farrar J, Merson L, Phuong L, Thwaites G, Van Kinh N, Thuy PT, Chierakul W, Siriboon S, Thiansukhon E, Onsanit S, Supphamongkholchaikul W, Chan AK, Heyderman R, Mwinjiwa E, van Oosterhout JJ, Imran D, Basri H, Mayxay M, Dance D, Phimmasone P, Rattanavong S, Lalloo DG, Day JN, CryptoDex I (2016) Adjunctive Dexamethasone in HIV-associated Cryptococcal meningitis. N Engl J Med 374:542–554PubMedPubMedCentralCrossRef

96.

Bernard SA, Gray TW, Buist MD, Jones BM, Silvester W, Gutteridge G, Smith K (2002) Treatment of comatose survivors of out-of-hospital cardiac arrest with induced hypothermia. N Engl J Med 346:557–563PubMedCrossRef

97.

Arrich J, Holzer M, Havel C, Mullner M, Herkner H (2016) Hypothermia for neuroprotection in adults after cardiopulmonary resuscitation. Cochrane Database Syst Rev 2:CD004128PubMed

98.

van der Worp HB, Macleod MR, Bath PM, Demotes J, Durand-Zaleski I, Gebhardt B, Gluud C, Kollmar R, Krieger DW, Lees KR, Molina C, Montaner J, Roine RO, Petersson J, Staykov D, Szabo I, Wardlaw JM, Schwab S, Euro HYPi (2014) EuroHYP-1: European multicenter, randomized, phase III clinical trial of therapeutic hypothermia plus best medical treatment vs. best medical treatment alone for acute ischemic stroke. Int J Stroke 9:642–645PubMedCrossRef

99.

Mourvillier B, Tubach F, van de Beek D, Garot D, Pichon N, Georges H, Lefevre LM, Bollaert PE, Boulain T, Luis D, Cariou A, Girardie P, Chelha R, Megarbane B, Delahaye A, Chalumeau-Lemoine L, Legriel S, Beuret P, Brivet F, Bruel C, Camou F, Chatellier D, Chillet P, Clair B, Constantin JM, Duguet A, Galliot R, Bayle F, Hyvernat H, Ouchenir K, Plantefeve G, Quenot JP, Richecoeur J, Schwebel C, Sirodot M, Esposito-Farese M, Le Tulzo Y, Wolff M (2013) Induced hypothermia in severe bacterial meningitis: a randomized clinical trial. JAMA 310:2174–2183PubMedCrossRef

100.

Legriel S, Lemiale V, Schenck M, Chelly J, Laurent V, Daviaud F, Srairi M, Hamdi A, Geri G, Rossignol T, Hilly-Ginoux J, Boisrame-Helms J, Louart B, Malissin I, Mongardon N, Planquette B, Thirion M, Merceron S, Canet E, Pico F, Tran-Dinh YR, Bedos JP, Azoulay E, Resche-Rigon M, Cariou A, Group HS (2016) Hypothermia for Neuroprotection in convulsive status Epilepticus. N Engl J Med 375:2457–2467PubMedCrossRef

101.

Rosenow F, Besser R, Hamer HM, Holtkamp M, Kluge S, Knake S, Rossetti A, Schneider D, Trinka E (2012) S2k-Leitlinie Status epilepticus im Erwachsenenalter. Leitlinien für Diagnostik und Therapie in der Neurologie

102.

Goyal M, Menon BK, van Zwam WH, Dippel DW, Mitchell PJ, Demchuk AM, Davalos A, Majoie CB, van der Lugt A, de Miquel MA, Donnan GA, Roos YB, Bonafe A, Jahan R, Diener HC, van den Berg LA, Levy EI, Berkhemer OA, Pereira VM, Rempel J, Millan M, Davis SM, Roy D, Thornton J, Roman LS, Ribo M, Beumer D, Stouch B, Brown S, Campbell BC, van Oostenbrugge RJ, Saver JL, Hill MD, Jovin TG, collaborators H (2016) Endovascular thrombectomy after large-vessel ischaemic stroke: A meta-analysis of individual patient data from five randomised trials. Lancet 387:1723–1731PubMedCrossRef

103.

Ringleb PA, Veltkamp R, Hamann GF, Röther J, Jansen O, Groden C (2015) S2k-Leitlinie Akuttherapie des ischämischen Schlaganfalls – Ergänzung 2015; Rekanalisierende Therapie. Leitlinien für Diagnostik und Therapie in der Neurologie

104.

van den Berg LA, Koelman DL, Berkhemer OA, Rozeman AD, Fransen PS, Beumer D, Dippel DW, van der Lugt A, van Oostenbrugge RJ, van Zwam WH, Brouwer PA, Jenniskens S, Boiten J, Lycklama ANGA, Vos JA, Schonewille WJ, Majoie CB, Roos YB, group MCps, Participating c (2015) Type of anesthesia and differences in clinical outcome after intra-arterial treatment for ischemic stroke. Stroke 46:1257–1262PubMedCrossRef

105.

Schonenberger S, Uhlmann L, Hacke W, Schieber S, Mundiyanapurath S, Purrucker JC, Nagel S, Klose C, Pfaff J, Bendszus M, Ringleb PA, Kieser M, Mohlenbruch MA, Bosel J (2016) Effect of conscious sedation vs general anesthesia on early neurological improvement among patients with Ischemic stroke undergoing Endovascular Thrombectomy: A randomized clinical trial. JAMA 316:1986–1996PubMedCrossRef

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