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01.12.2017 | Study protocol | Ausgabe 1/2017 Open Access

BMC Pregnancy and Childbirth 1/2017

INTER-ACT: prevention of pregnancy complications through an e-health driven interpregnancy lifestyle intervention – study protocol of a multicentre randomised controlled trial

Zeitschrift:
BMC Pregnancy and Childbirth > Ausgabe 1/2017
Autoren:
Annick Bogaerts, Lieveke Ameye, Margriet Bijlholt, Kelly Amuli, Dorine Heynickx, Roland Devlieger
Abbreviations
BMI
Body mass index
CONSORT
Consolidated Standards of Reporting Trials
CS
Caesarean section
eCRF
Electronic case report form
EGWG
Excessive gestational weight gain
EPDS
Edinburgh Postnatal Depression Scale
FWO
Fund for Scientific Research
GCP
Good clinical practice
GCT
Glucose challenge test
GDM
Gestational diabetes mellitus
GWG
Gestational weight gain
IOM
Institute of Medicine
KPAS
Kaiser Physical Activity Survey
LAS
Linear Analog Scale
LGA
Large-for-gestational-age
OGTT
Oral glucose tolerance test
PIH
Pregnancy-induced hypertension
PPWR
Postpartum weight retention
SMART
Specific, measurable, achievable, relevant and time specific
SOC
Sense of Coherence
sSTAI-6
Short form State Trait Anxiety Inventory six item

Background

Maternal pre-pregnancy weight is related to pregnancy- and birth outcomes. An excessive weight before conception increases the risk for pregnancy- and birth related complications such as gestational diabetes mellitus (GDM), pregnancy-induced hypertension (PIH), caesarean section (CS), or a large-for-gestational age (LGA) infant [14]. Besides, excessive gestational weight gain (EGWG), i.e. a gestational weight gain (GWG) higher than the recommended GWG by the Institute Of Medicine (IOM) [5], is also associated with these perinatal complications [68]. Both the pre-pregnancy BMI and gestational weight gain (GWG) are thus considerable risk factors of pregnancy and birth complications. Between 2009 and 2014, the Flanders Study centre Perinatal Epidemiology (SPE) collected data of almost 400.000 singleton pregnancies in Flanders, Belgium, on the combined association of GWG and pre-pregnancy BMI with the prevalence of the composite outcome of pregnancy and birth complications (i.e. at least one of four perinatal outcomes PIH, GDM, CS and/or LGA infant). The prevalence of the composite perinatal outcome was 26% in women with a normal BMI and an adequate GWG; 34% in women with a normal BMI but with an excessive GWG; and 66% in women with class III obesity (BMI ≥ 40) and excessive GWG [SPE, 2016 in progress]. A Norwegian study reported similar findings. Haugen et al. [9] found that normal weight and overweight women with EGWG had an increased risk for PIH, preeclampsia, CS, high birth weight (>4500 g) and LGA infant. Moreover, women of all BMI classes and with EGWG, except underweight women, had an increased risk of more than 2 kg postpartum weight retention (PPWR) at 18 months postpartum [9]. Conversely, a more recent study from Xiong et al. reported an increased likelihood of CS in underweight or normal weight women with EGWG compared to overweight or obese women EGWG [10]. Thus, these results highlight the importance of adequate GWG in all BMI groups.
Based on the guidelines of the Institute of Medicine (IOM) [5], one in three women in Flanders, Belgium, has excessive GWG: 25% in normal pre-pregnancy BMI, 58% in pre-pregnancy overweight, and 54% in pre-pregnancy obesity [11]. Half of the women with excessive GWG do not return to their pre-pregnancy weight after delivery, resulting in a doubled risk for pregnancy- and birth related complications in the next pregnancy [12]. Retention of the excessive weight gained during pregnancy (i.e. PPWR) can result in obesity and an increased risk of chronic disease in later life [1317]. Additionally, maternal obesity negatively affects the health of the offspring in childhood and in adulthood, by increasing the risk of obesity and the related risks of non-communicable diseases. Maternal obesity might therefore result in a vicious circle of obesity throughout generations [4, 18, 19].
Several lifestyle interventions have been implemented during pregnancy in an attempt to reduce GWG and prevent pregnancy- and birth related complications. Although these interventions showed moderate beneficial effects on GWG, they had no significant impact on pregnancy- and birth related complications [20], potentially due to the limited time window [21, 22]. Therefore, the international community of health experts has called for strategies that already intervene in the pre-conception period in order to timely acquire a healthy lifestyle and weight loss [1]. However, such strategies are still scarce [20], possibly due to unpredictability of becoming pregnant and not being linked to the health care system preconceptionally [23]. The few existing studies, though, show promising results in intervening during the preconception period [2427]. An opportunity to overcome the barrier of reaching women in their preconception period, is to commence interventions already in the postpartum period and continuing until the next pregnancy. Such interpregnancy interventions could potentially be a unique strategy to acquire a healthy lifestyle before a subsequent pregnancy starts.
Effective lifestyle interventions for weight management among postpartum women are usually based on a combination of diet and physical activity [2830]. Ideally, such lifestyle interventions go beyond education or advice alone and integrate behavioural change techniques such as goal setting, self-monitoring and feedback [25, 31]. Mobile applications are excellent tools to incorporate such behavioural change techniques for intervention efforts promoting a healthy lifestyle [32] that have been found effective in health behaviour change and weight loss [33].
The interpregnAncy Coaching for a healthy fuTure (INTER-ACT) intervention is an e-health driven and face-to-face combined coaching program that is implemented between two pregnancies and during the subsequent pregnancy of women with an excessive GWG in the previous pregnancy. The main aim of this study is to assess the effectiveness of the INTER-ACT intervention on the composite outcomes score (GDM, PIH, CS, LGA) in the next pregnancy. This will be evaluated through a randomised controlled trial with an intervention- and control arm.

Methods

Study setting

INTER-ACT is a multi-centre randomised controlled trial in which six hospitals from three provinces (Leuven, Antwerp and Limburg) in the Flanders region of Belgium are involved: University Hospital Leuven, University Hospital Antwerp, GasthuisZusters Hospitals Antwerp, St-Franciscus Hospital in Heusden-Zolder, Jessa Hospital in Hasselt, and Hospital Oost-Limburg in Genk. These university, regional, or peripheral hospitals deliver each year between 900 and 2600 new-borns. Recruitment of participants takes place in these hospitals. Baseline measurements, the intervention, and follow-up measurements take place in the hospitals, private clinics, ‘Kind & Gezin’ (Child & Family) organisations, or at home, depending on the preference of the participant.

Recruitment and eligibility criteria

Study midwives from the participating hospitals are responsible for the recruitment of participants at day 2 or 3 postpartum. To optimise recruitment, flyers and posters are placed in the waiting rooms of the participating hospitals in order to inform potential participants.
Inclusion criteria for participation in the study are the following: women aged ≥18 years; excessive gestational weight gain (above the IOM recommendations [5]) in the previous pregnancy; wish for a next pregnancy not excluded; proficiency of Dutch language; being able to use a smartphone. Exclusion criteria for participation are the following: unable or unwilling to give informed consent; no access to internet; requirement for complex medical diets; history of- or planned bariatric surgery; chronic disorders (e.g. diabetes mellitus type 1 or 2, thyroid disease, renal disease); significant psychiatric disorder; previous stillbirth. Women with twin pregnancies in either the pregnancy preceding the intervention or the subsequent pregnancy are excluded from the study. Participants can not follow other lifestyle interventions during their participation in the INTER-ACT study.

Randomisation

After inclusion at day 2 or 3 postpartum, an electronic data capture system (CASTOR) will randomise participants in the intervention or control group. Randomisation is revealed at week 6 postpartum. Due to the nature of the intervention (i.e. coaching sessions and use of mobile app, weighing scale and activity tracker), no blinding is involved in this study.

Intervention

The intervention consists of two intervention phases. The first intervention phase starts at 6 weeks postpartum and lasts until 6 months postpartum. The second intervention phase starts before the 15th week of the next pregnancy and lasts until the 35th week of the pregnancy. A deviation of 2 weeks before or after the planned time point is allowed. Both intervention phases comprise face-to-face coaching and use of a mobile application. Between the two intervention phases, participants in the intervention group receive motivational reminders by e-mail every 3 months.

Face-to-face coaching

During both intervention periods, women receive face-to-face coaching sessions: four during the interpregnancy period and three during the next pregnancy (Fig. 1). Coaches trained in motivational interviewing and behavioural change techniques conduct the coaching sessions. During the coaching sessions, the participant is sensitised about the benefits of a healthy lifestyle and the adoption of a healthy lifestyle is stimulated. SMART (Specific, Measurable, Achievable, Relevant and Time specific) goal setting, action planning and reinforcement support the adoption of a healthy lifestyle. Besides, potential barriers to achieving goals or a healthy lifestyle are identified as well as individually tailored solutions to overcome these barriers. The data from the mobile app, i.e. the evolution of body weight, physical activity and mental well-being, support these coaching sessions.

Mobile application

The mobile app runs throughout the intervention periods and consists of four domains: nutrition, physical activity, weight, and mental wellbeing. In the nutrition domain, the participant sets nutrition goals based on the Belgian ‘active food triangle’ [34]. If applicable, the nutrition goals are adapted for lactating or pregnant women. On a daily basis, the participant can indicate whether or not she achieved her nutrition goal. In the physical activity domain, the participant sets a goal regarding the number of steps she wants to achieve every day. A Bluetooth-connected activity and sleep tracker (Withings GO™) registers the participant’s activity and sleep, and allows the app to assess whether the physical activity goal is reached. Weight is recorded by a Bluetooth-connected weighing scale (Body Cardio Withings™). In the mental wellbeing domain, the participant can indicate her mood by choosing one out of five emoticons that express different mood states. Besides, the participant can indicate her stress level on a stress meter in the shape of a thermometer. Custom made tips are sent to support the participant in achieving her nutrition and physical activity goals. Additionally, based on the participant’s progress and mood state, the app sends positive coaching messages in order to further motivate the participant. The app development and pilot study of the app including results from evaluation questionnaires will be described in a subsequent paper.

Ensuring adherence

Adherence to the intervention is enhanced in several ways. Firstly, the coaching sessions coincide with the postnatal follow-up visit and government vaccine scheme (in the interpregnancy phase) and routine ultrasound scans during the 1st, 2nd and 3rd trimester of pregnancy (in the new pregnancy phase) in order to reduce barriers to attend the sessions. Secondly, the participants can choose the study location of their preference: at the hospital, private clinic, ‘Child & Family’ organisation, or at the home of the participant. Thirdly, between the two intervention phases, adherence to physical activity and healthy nutrition behaviour are stimulated by sending 3-monthly motivational coaching messages to the participant.

Participant timeline

Women are recruited at day 2 or 3 postpartum. Coaching sessions take place at week 6, week 8, week 12 and month 6 postpartum. Subsequently, coaching sessions take place before week 15, week 20 and week 35 in the next pregnancy. The mobile app is used from week 6 to month 6 postpartum and in the next pregnancy (Fig. 1).

Outcomes

In this RCT, we aim to evaluate a composite outcome as primary outcome, of which at least one of the following outcomes occurs in the subsequent pregnancy:
  • Pregnancy-induced hypertension (PIH): new-onset elevations of blood pressure (systolic blood pressure > 140 mmHg and diastolic blood pressure >90 mmHg) after 20 weeks of gestation without significant proteinuria [35].
  • Gestational diabetes mellitus (GDM): is defined as any degree of glucose intolerance with onset or first recognition during pregnancy [36]. GDM is diagnosed at 24–28 weeks of gestation with the two steps screening strategy which consists of a 50 g glucose challenge test (GCT) and a 2-h 75 g oral glucose tolerance test (OGTT). GDM is diagnosed upon an abnormal GCT (≥ 140 mg/dl) followed by an abnormal OGTT (≥ 153 mg/dl) based on the VDV-VVOG-Domus Medica consensus 2012 and IADPSG criteria [37].
  • Caesarean section (CS): surgical procedure in which a foetus is delivered through an incision in the mother’s abdomen and uterus.
  • Large-for-gestational-age baby (LGA): birth weight >90th percentile on Flemish sex- and parity-adjusted growth charts [38].
Secondary outcomes are the following:
  • Maternal weight
  • Body composition
  • Blood pressure
  • Breastfeeding
  • Food intake
  • Physical activity
  • Lifestyle behaviour
  • Quality of life
  • Mental wellbeing

Sample size

The primary endpoint is the composite endpoint of selected pregnancy- and birth-related complications: PIH, GDM, CS and LGA. PIH and GDM are assessed during pregnancy; CS and LGA are determined at time of delivery (Fig. 1). In order to find a significant difference between the intervention and control arm in the rate of the selected pregnancy- and birth-related complications (composite endpoint), assuming a 42% complication rate in the intervention arm and 30% in the control arm (1/4 relative reduction), with a statistical power of 80% and significance level of 0.05, we need 500 women with a next (second) delivery: 250 women in the intervention arm and 250 women in the control arm.
The figures for mean duration between birth and start of a new pregnancy vary around 18 to 24 months. We assume that 2/3 of the included women have a next delivery within 3 years since inclusion in the trial. We also take into account a 30% drop-out rate during follow-up till end of the next pregnancy. In order to obtain 500 women with a next delivery, taking into account a 30% drop-out and only 65% having a next pregnancy within 3 years, we need to include 500x(1/0.65)x(1/0.7) = 1100 women: 550 women per arm.

Data collection

Time of data collection

Clinical data (i.e. medical record data and anthropometric data) and non-clinical data (i.e. data from the mobile app and self-administered questionnaires) are collected at day 2–3, week 6, and month 6 postpartum, every subsequent 6 months until the next pregnancy, and at week <15, 20, and 35 during the next pregnancy (Fig. 1). Deviation of 2 weeks before or after the planned time point is allowed.
At inclusion (day 2 or 3 postpartum) and at the end of the subsequent pregnancy, data will be collected from the medical record. During each coaching session, data from the mobile app will be collected (intervention group only). During all measurement moments (except day 2/3 and delivery of the next pregnancy) anthropometric data and self-administered questionnaires are collected (Fig. 1).

Medical record data

Data from the medical record comprise pre-pregnancy weight, pregnancy weight gain, pregnancy- and birth outcomes, data of the new-born such as birthweight and LGA, familial medical history (familial type 2 diabetes mellitus, familial hypertension), chronic disease, psychological history; comorbidity; use of medication; medical history of (previous) pregnancy (GCT, OGTT, GDM, PIH, CS, proteinuria (>300 mg/24 h), preeclampsia, preterm delivery (<37 weeks of gestation) and miscarriage).

Anthropometric data

The anthropometric data consist of maternal weight, height, skinfold thickness, waist and hip circumference, body composition, and blood pressure. Maternal height will be measured by a Seca-213 Leicester stadiometer. Maternal weight and body composition (fat mass, fat free mass, muscle mass, extra-cellular water, intra-cellular water, organ fat and phase angle) will be measured with the Tanita MC 780 SMA bio-electric impedance analysis device. Skinfold thickness of the subscapular, suprailiac, biceps, and triceps will be measured with the Harpenden skinfold calliper and evaluated with the Harpenden skinfold calliper software program. Waist and hip circumferences are measured with a Seca 201 measuring tape in order to estimate abdominal body fat. Blood pressure is measured using the Microlife BP A150 AFIB device. All measurements will be performed according to the standard operating procedures to ensure data quality.

Mobile app data

Data from the mobile app, i.e. self-monitored weight, physical activity, emotional status, and stress level will be transferred to the secured INTER-ACT website where coaches can retrieve relevant data such as the self-monitored weight and the amount of physical activity.

Questionnaires data

A link to the self-administered questionnaires will be sent by e-mail or text message a few days before the study visit so that the participant can complete the questionnaires online before the study visit. Uncompleted questionnaires can be (further) completed during the study visit.
Socio-demographics questionnaire: assesses ethnicity, marital status, level of education and employment status.
Breastfeeding questionnaire: is based on existing questionnaires by Guelinckx et al. [39] and Bogaerts et al. (unpublished) and assesses type of infant feeding (i.e. breastfeeding, bottle-feeding or a combination), number of feedings per day, duration of having given/giving breastfeeding in weeks, and motives for cessation of breastfeeding.
Food Frequency Questionnaire: is developed and validated by Matthys et al. [40] and evaluates on the basis of 25 food items frequency of food intake (per day, per week or per month) and portion size (in gram or millilitre).
Kaiser Physical Activity Survey (KPAS): is validated for both pregnant and non-pregnant populations [41, 42] and assesses multiple domains of physical activity (household/caregiving, occupational, active living and sports/exercise).
Lifestyle behaviour questionnaire: is based on the questionnaires of the DALI study [43] and evaluates smoking behaviour, alcohol use, sleep duration and quality of sleep, and following a specific diet.
Short form State Trait Anxiety Inventory six item (sSTAI-6): measures anxiety symptoms, is validated to the original State Trait Anxiety Inventory (STAI) questionnaire [44] and is reliable and valid for use in the perinatal period [45].
Edinburgh Postnatal Depression Scale (EPDS): is a reliable and valid 10-item questionnaire that screens women for symptoms of emotional distress during pregnancy and the postnatal period [4648].
Sense of Coherence (SOC): is measured with the 13-item SOC questionnaire. The SOC-13 assesses comprehensibility, manageability, and meaningfulness of one’s life [49, 50]. It is a valid instrument used for non-pregnant and pregnant populations [51].
Linear Analog Scale (LAS): assesses quality of life by a vertically oriented scale with the lowest score 0, representing a poor quality of life, and the highest score 100 which represent a good quality of life [52].
Process evaluation questionnaire: is administered at the end of both intervention periods and evaluates the usability of the mobile app by the System Usability Scale [53], the participants’ experience with the app (i.e. the content of the app) and the face-to-face coaching.

Safety parameters

Possible adverse events associated with the intervention can be exercise-related adverse events or adverse events related to a rapid weight loss over a short period of time. Moreover, although the EPDS questionnaire is a screening tool and not a diagnostic tool for depression, a positive response on question 10 of the EPDS questionnaire, i.e. having suicidal thoughts, is considered alarming and will be reported to the principal investigator (PI). Based on the result and clinical judgment by the PI, women will be referred to a specialised health practitioner.

Data management

The data from the questionnaires, the anthropometric data and medical record will be entered and stored in a full Good Clinical Practice (GCP) compliant Electronic Data Capture system, i.e. the CASTOR electronic case report form (eCRF). The data of the mobile application (i.e. physical activity from the activity tracker, weight evolution and mood status) of the participants can be retrieved from the secured website of INTER-ACT, of which only the research team and the participant can have access. Length and weight after delivery will be transferred from the eCRF to the mobile application in order to be able to calculate BMI and show weight curves. In case of no database access, data will be entered on paper CRF and subsequently entered into the data system when access is possible.

Statistics

All analyses will be carried out using the intention-to-treat principle with data from all participants enrolled in the study. The statistical software SAS version 9.4 will be used. Descriptive statistics for baseline values in the two arms will be presented. There will be no tests of statistical significance or confidence intervals for differences between the two arms, as these are randomised groups. The drop-out rate will be assessed and compared between the two arms. The composite endpoint consists of occurrence of at least one of the following four major pregnancy and birth related complications, at time of next pregnancy: PIH, GDM, CS, and LGA. The rate of the composite endpoint will be calculated and 95% confidence intervals provided in intervention and control arm: 1) in all included patients (intent-to-treat), 2) in all patients completed a next pregnancy. If drop-out rates, reason for drop-out, next pregnancy rates differ between the intervention arm and control arm, the rate of the composite endpoint in patients with a next pregnancy has to be interpreted carefully.
A full statistical analysis plan will be written by the trial statistician prior to any analysis being undertaken. We will report data in line with the Consolidated Standards of Reporting Trials (CONSORT) 2010 Statement [54] and a P-values <0.05 will be considered statistically significant.

Discussion

Excessive weight before and during pregnancy is a public health threat since it may lead to pregnancy- and birth related complications such as pregnancy-induced hypertension, gestational diabetes mellitus, caesarean section, and large for gestational age infants in the short term and weight-related chronic diseases in the long run. Moreover, maternal obesity may lead to inter-generational cycles of obesity through intra-uterine programming of the foetus. Therefore it is essential to timely implement lifestyle interventions targeting high-risk groups.
INTER-ACT is a unique lifestyle intervention that focuses on weight, diet, physical activity and mental well-being between pregnancies and during a subsequent pregnancy with the aim to reduce pregnancy- and birth related complications. The intervention especially focuses on those who are most at risk of these complications in a subsequent pregnancy: women with excessive gestational weight gain during their previous pregnancy.
Strengths of this study can be found in 1) the design of this e-health driven randomised controlled trial, 2) the six participating study sites that represent the northern population of Belgium, and 3) the large sample size calculated as such to demonstrate differences between intervention and control group. A potential pitfall of this study is the long follow-up, i.e. until the end of the subsequent pregnancy, which might result in high drop-out rates. However, possible drop-outs were considered in the power calculations for the needed sample size. This study therefore has the strong potential to show the effectiveness of the e-health driven coaching program for women between and during pregnancies to obtain a healthy lifestyle, to achieve a healthy weight, and to reduce pregnancy- and birth related complications.

Acknowledgements

Not applicable.

Funding

This RCT is externally funded by the Fund for Scientific Research, ‘Fonds Wetenchappelijk Onderzoek’ (FWO): TBM (Applied Biomedical Research with Primary Social finality) project. Project number FWO: T005116N. Contact information: Egmontstraat 5, 1000 Brussel. Telephone: +32 2 512 91 10. E-mail: post@fwo.be. The funder had no role in study design; collection, management, analysis, and interpretation of data; writing of the report; and the decision to submit the report for publication, and will not have ultimate authority over any of these activities.

Availability of data

Data of the study can be retrieved by the principal investigator.

Authors’ contributions

A.B., L.A. and R.D. contributed to the conception and design of the trial and revised criticially on editing the manuscript. M.B. and K.A. contributed to the design of the trial and wrote the manuscript. D.H. contributed to the design of the trial and advised on editing the manuscript. All authors have read and approved the final version of the manuscript.

Competing interests

The authors declare that they have no competing interests.

Consent for publication

It is anticipated that the results of the overall study shall be published in a multi-centre publication, involving the data of all clinical sites participating in the study. The participating site is not allowed to publish any data or results from the study prior to the multicentre publication. Authorship to publications will be determined in accordance with the requirements of the respective medical journal.

Ethics approval and consent to participate

The study received approval on 8th of March 2017 from the central medical ethical committee UZ/KU Leuven, which provides the final favourable ethics approval, and the local ethics committees of the participating sites (i.e. GasthuisZusters ziekenhuizen Antwerpen; Universitair Ziekenhuis Antwerpen; Ziekenhuis Oost-Limburg Genk; Sint-Franciscus Ziekenhuis Heusden-Zolder; Jessa Ziekenhuis Hasselt). Any protocol amendments will be reported and submitted to the medical ethic committee.
Potential trial participants will be enrolled in the study by study midwives, after giving informed consent for data extraction from the medical records, data collection from the questionnaires and mobile app, and for performing physical measurements until the end of the subsequent pregnancy. The intervention is discontinued if the participant indicates she no longer wishes to participate.
Confidentiality and anonymity of the participant’s data will be ensured by attributing a participant ID number to the participants. All data will be coded and stored separately from any relevant identifiers to participant names. Only researchers from the study will have access to the data and no data will be disclosed to a third party.

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