Interaction and combined effect of triglyceride-glucose index and hypertension on type 2 diabetes individuals’ peripheral arterial disease risk
- 26.10.2024
- Original Article
Erschienen in:
- Verfasst von
- Caixia Gong
- Chongyang Chen
- Yangting Zhao
- Yawen Wang
- Kai Li
- Xiaoyu Lv
- Xinyuan Guo
- Dengrong Ma
- Xiaohui Zhai
- Mei Han
- Songbo Fu
- Jingfang Liu
- Erschienen in
- Acta Diabetologica | Ausgabe 5/2025
Abstract
Background
The interaction and combined effect of the triglyceride-glucose (TyG) index, an alternative parameter of insulin resistance, along with hypertension (HT), on the risk of peripheral arterial disease (PAD), a specific type of atherosclerotic cardiovascular disease, in individuals with type 2 diabetes (T2D) seems straightforward. However, specific research on this topic remains scarce.
Methods
In this cross-sectional study, 2027 adult participants with T2D were devided into four groups based on the mean values of TyG index and various blood pressure parameters along with its category. Binary logistic regression, interaction analysis, combined effect size, and goodness-of-fit of the constructed models were performed.
Results
The TyG index’s individual effect and it’s combined effect with HT, or higher systolic blood pressure (SBP) or higher mean arterial pressure in patients with T2D correlated with a higher PAD risk respectively (odds ratio [OR], 0.50, [95% confidence interval {CI} 0.28–0.89]; OR, 0.32, [95% CI 0.12–0.90]; OR, 0.35, [95% CI 0.13–0.94]; OR, 0.35, [95% CI 0.12–0.98], respectively). Only an interaction effect exists between the TyG index and SBP (multiplicative interaction{INTM}: 1.02 [1.002, 1.038]). Combining them can significantly improve the accuracy of predicting PAD (area under the receiver operating characteristic curve {AUC}MAX = 0.7, AUCModel3 + TyG index + SBP—AUCModel3 = 0.027). All P values were < 0.05.
Conclusion
This study suggested that TyG index and hypertension, as well as their combined and interaction effect were significantly correlated with the risk of PAD in T2D individuals.
Anzeige
- Titel
- Interaction and combined effect of triglyceride-glucose index and hypertension on type 2 diabetes individuals’ peripheral arterial disease risk
- Verfasst von
-
Caixia Gong
Chongyang Chen
Yangting Zhao
Yawen Wang
Kai Li
Xiaoyu Lv
Xinyuan Guo
Dengrong Ma
Xiaohui Zhai
Mei Han
Songbo Fu
Jingfang Liu
- Publikationsdatum
- 26.10.2024
- Verlag
- Springer Milan
- Erschienen in
-
Acta Diabetologica / Ausgabe 5/2025
Print ISSN: 0940-5429
Elektronische ISSN: 1432-5233 - DOI
- https://doi.org/10.1007/s00592-024-02391-1
Dieser Inhalt ist nur sichtbar, wenn du eingeloggt bist und die entsprechende Berechtigung hast.
Dieser Inhalt ist nur sichtbar, wenn du eingeloggt bist und die entsprechende Berechtigung hast.
