Background
Methods
The database
Patients
Definitions, diagnoses and grouping
Lab measurements
Statistical methods
Results
Characteristics | Total | Initial AMI | Non-CAD | P value |
---|---|---|---|---|
N | 3213 | 1522 | 1691 | |
Demographic data | ||||
Age (IQR), year | 63 (15) | 64 (18) | 62 (13) | < 0.001 |
Male n (%) | 2117 (65.9) | 1229 (80.8) | 888 (52.5) | < 0.001 |
Height (IQR), cm | 165 (10) | 165 (9) | 163 (12) | < 0.001 |
Weight (IQR), kg | 65 (11) | 65 (7) | 65 (14) | 0.693 |
BMI (IQR) | 24.1 (3.0) | 24.1 (1.4) | 24.4 (4.0) | < 0.001 |
Marriage n (%) | 0.019 | |||
Divorced | 3 (0.1) | 3 (0.2) | 0 (0.0) | |
Married | 3168 (98.6) | 1492 (98.0) | 1676 (99.1) | |
Unmarried | 25 (0.8) | 15 (1.0) | 10 (0.6) | |
Widowed | 17 (0.5) | 12 (0.8) | 5 (0.3) | |
Life styles | ||||
Smoking status n (%) | < 0.001 | |||
Never | 1681 (52.3) | 578 (38.0) | 1103 (65.2) | |
Past smoking | 276 (8.6) | 123 (8.1) | 153 (9.1) | |
Current smoking | 1256 (39.1) | 821 (53.9) | 435 (25.7) | |
Drinking status n (%) | < 0.001 | |||
Never | 2488 (77.4) | 1108 (72.8) | 1380 (81.6) | |
Past drinking | 73 (2.3) | 35 (2.3) | 38 (2.3) | |
Current drinking | 652 (20.3) | 379 (24.9) | 273 (16.1) | |
Past history n (%) | ||||
PH | 2029 (63.2) | 926 (60.8) | 1103 (65.2) | 0.010 |
DM | 616 (19.2) | 346 (22.7) | 270 (16.0) | < 0.001 |
Blood analysis | ||||
Total protein (IQR), g/l | 66.4 (8.1) | 64.8 (7.7) | 67.4 (7.7) | < 0.001 |
Albumin (IQR), g/l | 41.1 (5.5) | 39.5 (5.8) | 42.1 (4.9) | < 0.001 |
Creatinine (IQR), μmol/l | 74.0 (24.0) | 78.0 (24.1) | 72.0 (23.0) | < 0.001 |
ALT (IQR), u/l | 26.0 (29.0) | 40.2 (39.8) | 19.0 (13.0) | < 0.001 |
AST (IQR), u/l | 30.0 (97.0) | 123.5 (245.0) | 22.0 (8.0) | < 0.001 |
Hemoglobin (IQR), g/l | 135.0 (19.0) | 135.0 (20.0) | 134.0 (19.0) | 0.375 |
Lipid profiles | ||||
TC, mmol/l | 4.1 (1.3) | 4.1 (1.3) | 4.0 (1.2) | < 0.001 |
TG, mmol/l | 1.3 (1.0) | 1.2 (1.0) | 1.3 (1.0) | 0.009 |
Lp(a), mg/l | 88 (158) | 111 (192) | 71 (126) | < 0.001 |
Apo A, g/l | 1.3 (0.2) | 1.2 (0.2) | 1.3 (0.2) | < 0.001 |
Apo B, g/l | 0.9 (0.3) | 0.9 (0.3) | 0.9 (0.3) | < 0.001 |
HDL-C, mmol/l | 1.1 (0.3) | 1.0 (0.3) | 1.1 (0.3) | < 0.001 |
LDL-C, mmol/l | 2.5 (1.0) | 2.6 (1.1) | 2.4 (0.9) | 0.038 |
Medications n (%) | 0.001 | |||
Rosuvastatin | 326 (15.7) | 223 (15.9) | 103 (15.5) | |
Fluvastatin | 11 (0.5) | 3 (0.2) | 8 (1.2) | |
Atorvastatin | 897 (43.3) | 638 (45.4) | 259 (39.0) | |
Simvastatin | 837 (40.4) | 542 (38.6) | 295 (44.4) | |
Imaging | ||||
CAG n (%) | 3076 (95.7) | 1385 (91.0) | 1691 (100.0) | < 0.001 |
Odds ratios of first incident AMI in higher BMI alone
Lp(a) | BMI < 24 | BMI ≥ 24 | bORs(95% CI) for higher BMI within strata of Lp(a) | ||||
---|---|---|---|---|---|---|---|
N(ca/co) | Crude aOR (95% CI) | aOR (95% CI) | N(ca/co) | Crude aOR (95% CI) | aOR (95% CI) | ||
Q1 | 177/61 | 1.0 | 1.0 | 254/166 | 1.90 (1.34–2.69) | 2.27 (1.46–3.52) | 2.27 (1.46–3.52) |
Q2 | 150/82 | 1.59 (1.07–2.36) | 1.79 (1.11–2.90) | 204/195 | 2.77 (1.95–3.94) | 2.86 (1.85–4.40) | 1.71 (1.14–2.56) |
Q3 | 161/90 | 1.62 (1.10–2.39) | 1.65 (1.05–2.60) | 189/212 | 3.25 (2.29–4.62) | 3.30 (2.14–5.11) | 1.93 (1.32–2.82) |
Q4 | 137/103 | 2.18 (1.48–3.21) | 1.96 (1.20–3.20) | 154/237 | 4.46 (3.13–6.37) | 4.43 (2.76–7.09) | 2.56 (1.68–3.91) |
Q5 | 137/137 | 2.90 (1.99–4.22) | 2.34 (1.47–3.71) | 128/239 | 5.42 (3.77–7.79) | 5.98 (3.72–9.60) | 2.43 (1.63–3.62) |
cOR(95% CI) for higherLp(a) within strata of BMI | 1.79 (1.11,2.90) | 1.26 (0.91–1.75) | |||||
1.65 (1.05,2.60) | 1.38 (0.99–1.93) | ||||||
1.96 (1.20,3.20) | 1.68 (1.18–2.39) | ||||||
2.34 (1.47–3.71) | 2.23 (1.56–3.17) |
Odds ratios of first incident AMI in higher Lp(a) alone
Odds ratios of first incident AMI in both higher BMI and higher Lp(a) levels
Interactive effects of both higher BMI and higher Lp(a) levels on the risk of first incident AMI
Lp(a) | RERI(95% CI) | P | Product term OR(95% CI) | P |
---|---|---|---|---|
Q2 (≤65 mg/l) | −0.03(−1.08–1.02) | 0.96 | 0.77 (0.44–1.35) | 0.36 |
Q3 (≤118 mg/l) | 0.38(−0.66–1.42) | 0.47 | 0.89 (0.51–1.54) | 0.67 |
Q4 (≤246.9 mg/l) | 1.26(−0.19–2.72) | 0.09 | 0.95 (0.54–1.70) | 0.88 |
Q5 (≤2138 mg/l) | 2.45 (0.36–4.54) | 0.02 | 0.96 (0.55–1.68) | 0.89 |