nach oben

Sleep and Breathing

Erschienen in:

07.07.2021 | Sleep Breathing Physiology and Disorders • Original Article

Interactions of central and autonomic nervous systems in patients with sleep apnea–hypopnea syndrome during sleep

verfasst von: Tingting Wang, Juan Yang, Yingjie Song, Feng Pang, Xinwen Guo, Yuxi Luo

Erschienen in: Sleep and Breathing | Ausgabe 2/2022

Einloggen, um Zugang zu erhalten

Abstract

Purpose

Sleep apnea–hypopnea syndrome (SAHS) is an independent risk factor for various cardiovascular and cerebrovascular diseases, but the underlying relationship of its physiological subsystems remains unclear. Thus, we aimed to investigate the effect of SAHS on central and autonomic nervous system (CNS-ANS) interactions during sleep.

Methods

Thirty-five patients with SAHS and 19 healthy age-matched controls underwent overnight polysomnography. The absolute spectral powers of five frequency bands from six EEG channels and ECG morphological features (HR, PR interval, QT interval) were calculated. Multivariable transfer entropy was applied to analyze the differences of the CNS-ANS network interactions between patients with SAHS of different severities and healthy controls during deep, light, and rapid eye movement sleep.

Results

The CNS-ANS network interacted bidirectionally in all researched groups, with the cardiac information modulating the brain activity. The information strength from QT to most EEG components and PR to some EEG components was significantly affected by SAHS severity during light sleep, which indicates the coupling features of QT-brain nodes are important indicators. The driver effects from the β-band significantly increased in patients with SAHS.

Conclusions

Respiratory events may be the main reason for the CNS-ANS interaction changes in SAHS. These findings help explain the physiological regulation process of SAHS and provide valuable information for analysis of the development of SAHS-related cardiovascular and chronic diseases.

Nur mit Berechtigung zugänglich

the interval between two adjacent R peaks;

the interval from the start of the P-wave to the start of the QRS complex;

the interval from the start of the QRS complex to the end of the T-wave.

Dempsey JA, Veasey SC, Morgan BJ, O’Donnell CP (2010) Pathophysiology of sleep apnea. Physiol Rev 90(1):47–112PubMedPubMedCentralCrossRef

Benjafield AV, Ayas NT, Eastwood PR, Heinzer R, Ip MSM, Morrell MJ et al (2019) Estimation of the global prevalence and burden of obstructive sleep apnoea: a literature-based analysis. Lancet Respir Med 7(8):687–698PubMedPubMedCentralCrossRef

Ott SR, Korostovtseva L, Schmidt M, Horvath T, Brill AK, Bassetti CL (2017) Sleep-disordered breathing: clinical features, pathophysiology and diagnosis. Swiss Med Wkly 147:w14436PubMed

Sarkar P, Mukherjee S, Chai-Coetzer CL, McEvoy RD (2018) The epidemiology of obstructive sleep apnoea and cardiovascular disease. J Thorac Dis 10(Suppl 34):S4189–S4200PubMedPubMedCentralCrossRef

Floras JS (2015) Hypertension and sleep apnea. Can J Cardiol 31(7):889–897PubMedCrossRef

Di Fusco SA, Pignalberi C, Santini L, Colivicchi F, Santini M (2020) Arrhythmias and sleep apnea: physiopathologic link and clinical implications. J Interv Card Electrophysiol 57(3):387–397PubMedCrossRef

Hla KM, Young T, Hagen EW, Stein JH, Finn LA, Nieto FJ et al (2015) Coronary heart disease incidence in sleep disordered breathing: the Wisconsin Sleep Cohort Study. Sleep 38(5):677–684PubMedPubMedCentralCrossRef

Parati G, Lombardi C, Castagna F, Mattaliano P, Filardi PP, Agostoni P et al (2016) Heart failure and sleep disorders. Nat Rev Cardiol 13(7):389–403PubMedCrossRef

Koo DL, Nam H, Thomas RJ, Yun CH (2018) Sleep disturbances as a risk factor for stroke. J Stroke 20(1):12–32PubMedPubMedCentralCrossRef

10.

Redline S, Kirchner L, Quan SF, Gottlieb DJ, Kapur V, Newman A (2004) The effects of age, sex, ethnicity, and sleep-disordered breathing on sleep architecture. Arch Intern Med 164(4):406–418PubMedCrossRef

11.

Zeng L, Liang J, Liao Y, Zhou G, Zhang X, Luo Y (2019) Variation of electrocardiogram features across sleep stages in healthy controls and in patients with sleep apnea hypopnea syndrome. Int Heart J 60(1):121–128PubMedCrossRef

12.

Liang J, Zhang X, He X, Ling L, Zeng C, Luo Y (2018) The independent and combined effects of respiratory events and cortical arousals on the autonomic nervous system across sleep stages. Sleep Breath 22(4):1161–1168PubMedCrossRef

13.

Liang J, Zhang X, Luo Y, Wang T, Sun L, Huang S (2018) The impact of respiratory events on the autonomic nervous system during sleep. Int Heart J 59(2):378–386PubMedCrossRef

14.

Zambotti MD, Trinder J, Silvani A, Colrain IM, Baker FC (2018) Dynamic coupling between the central and autonomic nervous systems during sleep: a review. Neurosci Biobehav Rev 90:84–103PubMedPubMedCentralCrossRef

15.

Silvani A, Calandra-Buonaura G, Dampney RA, Cortelli P (2016) Brain-heart interactions: physiology and clinical implications. Philos Trans A Math Phys Eng Sci 374(2067)

16.

Jurysta F, Lanquart JP, van de Borne P, Migeotte PF (2006) The link between cardiac autonomic activity and sleep delta power is altered in men with sleep apnea-hypopnea syndrome. Am J Physiol-Reg I 291(4):R1165–R1171

17.

Rothenberger SD, Krafty RT, Taylor BJ, Cribbet MR, Thayer JF, Buysse DJ et al (2015) Time-varying correlations between delta EEG power and heart rate variability in midlife women: the SWAN Sleep Study. Psychophysiology 52(4):572–584PubMedCrossRef

18.

Orjuela-Canon AD, Cerquera A, Freund JA, Julia-Serda G, Ravelo-Garcia AG (2020) Sleep apnea: tracking effects of a first session of CPAP therapy by means of Granger causality. Comput Methods Programs Biomed 187:105235PubMedCrossRef

19.

Knyazev GG (2012) EEG delta oscillations as a correlate of basic homeostatic and motivational processes. Neurosci Biobehav Rev 36(1):677–695PubMedCrossRef

20.

Bazanova OM, Vernon D (2014) Interpreting EEG alpha activity. Neurosci Biobehav Rev 44:94–110PubMedCrossRef

21.

Yang J, Pan Y, Wang T, Zhang X, Wen J, Luo Y (2020) Sleep-dependent directional interactions of the central nervous system-cardiorespiratory network. IEEE Trans Biomed Eng 68(2):639–649CrossRef

22.

Perlis ML, Smith MT, Andrews PJ, Orff H, Giles DE (2001) Beta/gamma EEG activity in patients with primary and secondary insomnia and good sleeper controls. Sleep 24(1):110–117PubMedCrossRef

23.

Knyazev GG (2007) Motivation, emotion, and their inhibitory control mirrored in brain oscillations. Neurosci Biobehav Rev 31(3):377–395PubMedCrossRef

24.

Jurysta F, van de Borne P, Migeotte PF, Dumont M, Lanquart JP, Degaute JP et al (2003) A study of the dynamic interactions between sleep EEG and heart rate variability in healthy young men. Clin Neurophysiol 114(11):2146–2155PubMedCrossRef

25.

Schreiber T (2000) Measuring information transfer. Phys Rev Lett 85(2):461–464PubMedCrossRef

26.

Vicente R, Wibral M, Lindner M, Pipa G (2011) Transfer entropy-a model-free measure of effective connectivity for the neurosciences. J Comput Neurosci 30(1):45–67PubMedCrossRef

27.

Schulz S, Haueisen J, Bär KJ, Voss A (2019) Altered causal coupling pathways within the central-autonomic-network in patients suffering from schizophrenia. Entropy 21(8):733PubMedCentralCrossRef

28.

Montalto A, Faes L, Marinazzo D (2014) MuTE: a MATLAB toolbox to compare established and novel estimators of the multivariate transfer entropy. PLoS One 9(10):e109462PubMedPubMedCentralCrossRef

29.

Fink AM, Bronas UG, Calik MW (2018) Autonomic regulation during sleep and wakefulness: a review with implications for defining the pathophysiology of neurological disorders. Clin Auton Res 28(6):509–518PubMedPubMedCentralCrossRef

30.

Abdullah H, Maddage N, Cosic I, Cvetkovic D (2010) Brain and heart interaction during sleep in the healthy and sleep apnoea. Paper presented at the 2010 IEEE EMBS Conference on Biomedical Engineering and Sciences (IECBES 2010), Kuala Lumpur, Malaysia, 30 Nov-2 Dec

31.

Khandoker AH, Karmakar CK, Palaniswami M (2008) Analysis of coherence between sleep EEG and ECG signals during and after obstructive sleep apnea events. Paper presented at the 30th Annual International Conference of the IEEE-Engineering-in-Medicine-and-Biology-Society, Vancouver, Canada, 20–24 Aug

32.

Long X, Arends JB, Aarts RM, Haakma R, Fonseca P, Rolink J (2015) Time delay between cardiac and brain activity during sleep transitions. Appl Phys Lett 106(14):4CrossRef

33.

Yan J, Zhang X, Yen C-W, Sun L, Yu E, Luo Y (2016) Role of electroencephalogram and oxygen saturation in the induction mechanism of arousal for obstructive sleep apnea-hypopnea syndrome patients. Biol Rhythm Res 47(4):483–495CrossRef

34.

Zhou G, Pan Y, Liao Y, Liang J, Zhang X, Luo Y (2020) Short-term impact of sleep apnea/hypopnea on the interaction between various cortical areas. Clin EEG Neurosci 52(4):296–306PubMedCrossRef

35.

Huang S, Wang T, Zhang X, Yen CW, Liang J, Zeng L et al (2018) The correlations between electroencephalogram frequency components and restoration of stable breathing from respiratory events in sleep apnea hypopnea syndrome. Respir Physiol Neurobiol 258:91–97PubMedCrossRef

36.

Gami AS, Olson EJ, Shen WK, Wright RS, Ballman KV, Hodge DO et al (2013) Obstructive sleep apnea and the risk of sudden cardiac death: a longitudinal study of 10,701 adults. J Am Coll Cardiol 62(7):610–616PubMedCrossRef

37.

Seyerle AA, Lin HJ, Gogarten SM, Stilp A, Giraldez RM, Soliman E et al (2018) Genome-wide association study of PR interval in Hispanics/Latinos identifies novel locus at ID2. Heart 104(11):904–911PubMedCrossRef

38.

Neyroud N, Maison-Blanche P, Denjoy I, Chevret S, Donger C, Dausse E et al (1998) Diagnostic performance of QT interval variables form 24-h electrocardiography in the long QT syndrome. Eur Heart J 19(1):158–165PubMedCrossRef

39.

Browne KF, Prystowsky E, Heger JJ, Chilson DA, Zipes DP (1983) Prolongation of the Q-T interval in man during sleep. AM J Cardiol 52(1):55–59PubMedCrossRef

40.

Roche F, Gaspoz JM, Court-Fortune I, Costes F, Geyssant A, Duverney D et al (2003) Alteration of QT rate dependence reflects cardiac autonomic imbalance in patients with obstructive sleep apnea syndrome. Pace-Pacing Clin Electrophysiol 26(7):1446–1453PubMedCrossRef

41.

Gillis AM, Stoohs R, Guilleminault C (1991) Changes in the QT interval during obstructive sleep apnea. Sleep 14(4):346–350PubMedCrossRef

42.

Poliakova N, Despres JP, Bergeron J, Almeras N, Tremblay A, Poirier P (2012) Influence of obesity indices, metabolic parameters and age on cardiac autonomic function in abdominally obese men. Metabolism 61(9):1270–1279PubMedCrossRef

Titel: Interactions of central and autonomic nervous systems in patients with sleep apnea–hypopnea syndrome during sleep
verfasst von: Tingting Wang
Juan Yang
Yingjie Song
Feng Pang
Xinwen Guo
Yuxi Luo
Publikationsdatum: 07.07.2021
Verlag: Springer International Publishing
Erschienen in: Sleep and Breathing / Ausgabe 2/2022
Print ISSN: 1520-9512
Elektronische ISSN: 1522-1709
DOI: https://doi.org/10.1007/s11325-021-02429-6

Leitlinien kompakt für die Innere Medizin

Mit medbee Pocketcards sicher entscheiden.

^{Seit 2022 gehört die medbee GmbH zum Springer Medizin Verlag}

Kostenlos registrieren

Neu im Fachgebiet Innere Medizin

24.04.2024 | DGIM 2024 | Kongressbericht | Nachrichten

Update Innere Medizin

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.

Newsletter bestellen

Springer Medizin

Interactions of central and autonomic nervous systems in patients with sleep apnea–hypopnea syndrome during sleep

Abstract

Purpose

Methods

Results

Conclusions

Leitlinien kompakt für die Innere Medizin

Neu im Fachgebiet Innere Medizin

Metformin rückt in den Hintergrund

Myokarditis nach Infekt – richtig schwierig wird es bei Profisportlern

Thrombophiliescreening – Wenn, dann richtig und nur bei therapeutischer Konsequenz

Bei Senioren mit Prostatakarzinom auf Anämie achten!

Update Innere Medizin

Springer Medizin

Abstract

Purpose

Methods

Results

Conclusions

Bitte loggen Sie sich ein, um Zugang zu diesem Inhalt zu erhalten

Weitere Artikel der Ausgabe 2/2022

Effect of sinus opacification on the severity of obstructive sleep apnea

The impact of the COVID-19 pandemic on positive airway pressure usage in children with sleep-disordered breathing

Daytime polysomnography to perform titration for upper airway stimulation in patients with obstructive sleep apnea

Effects of vibratory feedback stimuli through an oral appliance on sleep bruxism: a 6-week intervention trial

Depression and obesity, but not mild obstructive sleep apnea, are associated factors for female sexual dysfunction

Integrating the precision, sleep, and aerospace medicine fields: a systematic review of the genetic predisposition for obstructive sleep apnea in military aviation

Leitlinien kompakt für die Innere Medizin

Neu im Fachgebiet Innere Medizin

Metformin rückt in den Hintergrund

Myokarditis nach Infekt – richtig schwierig wird es bei Profisportlern

Thrombophiliescreening – Wenn, dann richtig und nur bei therapeutischer Konsequenz

Bei Senioren mit Prostatakarzinom auf Anämie achten!

Update Innere Medizin