Erschienen in:
18.03.2020 | Assisted Reproduction Technologies
Interleukin 6 in follicular fluid reduces embryo fragmentation and improves the clinical pregnancy rate
verfasst von:
Jie Yang, Xiaoling Yang, Hong Yang, Yang Bai, Hao Zha, Fangjie Jiang, Yushi Meng
Erschienen in:
Journal of Assisted Reproduction and Genetics
|
Ausgabe 5/2020
Einloggen, um Zugang zu erhalten
Abstract
Purpose
The aim of this study was to evaluate the role of interleukin 6 in embryo development in the in vitro fertilization cycles.
Methods
This was a retrospective cohort study. One hundred and three women undergoing in vitro fertilization and embryo transfer due to a tubal factor were included in the study. The follicular fluid IL-6 levels on oocyte retrieval day from each patient were determined by ELISA. The relationships between follicular fluid IL-6 levels and IVF cycle parameters were investigated.
Results
The levels of follicular fluid IL-6 were not affected by the use of drugs for superovulation or by estrogen. In addition, follicular fluid IL-6 levels did not affect the number of oocytes retrieved or the MII oocyte rate. High levels of follicular fluid IL-6 correlated with a significant increase in the rates of clinical pregnancy. Follicular fluid IL-6 levels did not affect the cell number or the blastomere symmetry of day 3 embryos, but it did significantly reduce the embryo fragmentation rate.
Conclusions
High levels of follicular fluid IL-6 improved the rates of clinical pregnancy and reduce embryo fragmentation.