The online version of this article (https://doi.org/10.1186/s13014-018-1107-x) contains supplementary material, which is available to authorized users.
Although patients experience radiation proctitis post radiotherapy no internationally tested instruments exist to measure these symptoms. This Phase IV study tested the scale structure, reliability and validity and cross-cultural applicability of the EORTC proctitis module (QLQ-PRT23) in patients who were receiving pelvic radiotherapy.
Patients (n = 358) from six countries completed the EORTC QLQ-C30, QLQ-PRT23 and EORTC Quality of Life Group debriefing questions. Clinicians completed the EORTC Radiation Therapy Oncology Group scale. Questionnaires were completed at four time-points. The module’s scale structure was examined and validated using standard psychometric analysis techniques.
Three items were dropped from the module (QLQ-PRT23 → QLQ-PRT20). Factor analysis identified five factors in the module: bowel control; bloating and gas; emotional function/lifestyle; pain; and leakage. Inter-item correlations were within r = 0.3–0.7. Test-Retest reliability was high. All multi-item scales discriminated between patients showing symptoms and those without symptomology. The module discriminated symptoms from the clinician completed scoring and for age, gender and comorbidities.
The EORTC QLQ-PRT20 is designed to be used in addition to the EORTC QLQ-C30 to measure quality of life in patients who receive pelvic radiotherapy. The EORTC QLQ-PRT20 is quick to complete, acceptable to patients, has good content validity and high reliability.
Australian and New Zealand Clinical Trials Registry (ANZCTR) ACTRN12609000972224.
Additional file 1: Treatment received by participants. (DOCX 18 kb)13014_2018_1107_MOESM1_ESM.docx
Additional file 2: Number of patients with existing co-morbidities and type. (DOCX 13 kb)13014_2018_1107_MOESM2_ESM.docx
Additional file 3: Means and 95% confidence intervals, range of the proposed QLQ PRT20 Proposed Scale compared to the RTOG score ratings indicting no symptoms (score = 0) vs. acute symptoms (score = 1+). (DOCX 13 kb)13014_2018_1107_MOESM3_ESM.docx
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- International validation of the EORTC QLQ-PRT20 module for assessment of quality of life symptoms relating to radiation proctitis: a phase IV study
Georgia K. B. Halkett
Charles Adam Wigley
Samar M Aoun
on behalf of the EORTC Quality of Life Group
- BioMed Central
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