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European Journal of Clinical Microbiology & Infectious Diseases

Erschienen in:

13.10.2022 | Brief Report

Interspecies differences in clinical characteristics and risk factors for third-generation cephalosporin resistance between Escherichia coli and Klebsiella pneumoniae bloodstream infection in patients with liver cirrhosis

verfasst von: Sin Young Ham, Hyungul Jung, Kyoung-Ho Song, Hyeonju Jeong, Jongtak Jung, Song Mi Moon, Jeong Su Park, Nak-Hyun Kim, Eun Sun Jang, Jin-Wook Kim, Sook-Hyang Jeong, Eu Suk Kim, Hong Bin Kim

Erschienen in: European Journal of Clinical Microbiology & Infectious Diseases | Ausgabe 12/2022

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Abstract

This retrospective study aimed to clarify the interspecies differences in the clinical characteristics and risk factors of bloodstream infection (BSI) due to third-generation cephalosporin-resistant (3GC-R) Escherichia coli (EC) and Klebsiella pneumoniae (KP) in patients with liver cirrhosis (LC). KP BSI had more comorbidities and higher treatment failure rate than EC BSI. Non-alcoholic LC was a risk factor for treatment failure in EC, whereas it was not associated with KP. Risk factors for BSI due to 3GC-R strain were nosocomial infection in EC, and β-lactam/fluoroquinolone treatment ≤ 30 days in KP. These results could help predict outcomes of BSI and improve clinical practice.

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Titel: Interspecies differences in clinical characteristics and risk factors for third-generation cephalosporin resistance between Escherichia coli and Klebsiella pneumoniae bloodstream infection in patients with liver cirrhosis
verfasst von: Sin Young Ham
Hyungul Jung
Kyoung-Ho Song
Hyeonju Jeong
Jongtak Jung
Song Mi Moon
Jeong Su Park
Nak-Hyun Kim
Eun Sun Jang
Jin-Wook Kim
Sook-Hyang Jeong
Eu Suk Kim
Hong Bin Kim
Publikationsdatum: 13.10.2022
Verlag: Springer Berlin Heidelberg
Erschienen in: European Journal of Clinical Microbiology & Infectious Diseases / Ausgabe 12/2022
Print ISSN: 0934-9723
Elektronische ISSN: 1435-4373
DOI: https://doi.org/10.1007/s10096-022-04508-2

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Interspecies differences in clinical characteristics and risk factors for third-generation cephalosporin resistance between Escherichia coli and Klebsiella pneumoniae bloodstream infection in patients with liver cirrhosis

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