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Erschienen in: Die Innere Medizin 9/2008

01.09.2008 | Schwerpunkt

Interventionelle Therapie des akuten Herzinfarkts

verfasst von: Prof. Dr. R. Zahn, U. Zeymer

Erschienen in: Die Innere Medizin | Ausgabe 9/2008

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Zusammenfassung

Der akute Myokardinfarkt wird heute in einen ST-Hebungsinfarkt (STEMI) und einen Nicht-ST-Hebungsinfarkt (NSTEMI) eingeteilt. Für die Praxis bedeutsamer, da sich alle Empfehlungen der Leitlinien bzgl. des invasiven Vorgehens danach richten, ist aber die Einteilung in ein akutes Koronarsyndrom mit ST-Hebungen (STE-ACS = STEMI) und eines ohne ST-Hebungen (NSTE-ACS). Letzteres wird nochmals unterteilt in ein NSTE-ACS mit oder ohne Risikomerkmale. Für das NSTE-ACS mit Risikomerkmalen wird allgemein eine frühe invasive Abklärung innerhalb von 72 h nach Diagnosestellung empfohlen, während das NSTE-ACS ohne Risikomerkmale zunächst rein medikamentös konservativ behandelt werden kann. Bezüglich des STEMI ist die Primärdilatation eindeutig Mittel der Wahl, wenn sie innerhalb von 2 h nach Diagnosestellung an einem erfahrenen Interventionszentrum mit kurzen Pforte-Ballon-Zeiten durchgeführt werden kann. Da dies in Deutschland prinzipiell flächendeckend möglich ist, ist es zurzeit die primäre Aufgabe, lokale Netzwerke zu errichten, um dies zu gewährleisten.
Literatur
1.
Zurück zum Zitat Andersen HR, Nielsen TT, Rasmussen K et al. (2003) A comparison of coronary angioplasty with fibrinolytic therapy in acute myocardial infarction. N Engl J Med 349: 733–742PubMedCrossRef Andersen HR, Nielsen TT, Rasmussen K et al. (2003) A comparison of coronary angioplasty with fibrinolytic therapy in acute myocardial infarction. N Engl J Med 349: 733–742PubMedCrossRef
2.
Zurück zum Zitat Bassand JP, Hamm CW, Ardissino D et al. (2007) Guidelines for the diagnosis and treatment of non-ST-segment elevation acute coronary syndromes: The Task Force for the Diagnosis and Treatment of Non-ST-Segment Elevation Acute Coronary Syndromes of the European Society of Cardiology. Eur Heart J 28: 1598–1660PubMedCrossRef Bassand JP, Hamm CW, Ardissino D et al. (2007) Guidelines for the diagnosis and treatment of non-ST-segment elevation acute coronary syndromes: The Task Force for the Diagnosis and Treatment of Non-ST-Segment Elevation Acute Coronary Syndromes of the European Society of Cardiology. Eur Heart J 28: 1598–1660PubMedCrossRef
3.
Zurück zum Zitat Boden WE, O’Rourke RA, Crawford MH et al. (1998) Outcomes in patients with acute non-Q-wave myocardial infarction randomly assigned to an invasive as compared with a conservative management strategy. Veterans Affairs Non-Q-Wave Infarction Strategies in Hospital (VANQWISH) Trial Investigators. N Engl J Med 338: 1785–1792PubMedCrossRef Boden WE, O’Rourke RA, Crawford MH et al. (1998) Outcomes in patients with acute non-Q-wave myocardial infarction randomly assigned to an invasive as compared with a conservative management strategy. Veterans Affairs Non-Q-Wave Infarction Strategies in Hospital (VANQWISH) Trial Investigators. N Engl J Med 338: 1785–1792PubMedCrossRef
4.
Zurück zum Zitat Boersma E (2006) Does time matter? A pooled analysis of randomized clinical trials comparing primary percutaneous coronary intervention and in-hospital fibrinolysis in acute myocardial infarction patients. Eur Heart J 27: 779–788PubMedCrossRef Boersma E (2006) Does time matter? A pooled analysis of randomized clinical trials comparing primary percutaneous coronary intervention and in-hospital fibrinolysis in acute myocardial infarction patients. Eur Heart J 27: 779–788PubMedCrossRef
5.
Zurück zum Zitat Bruckenberger E (2007) Herzbericht 2006. 19. Bericht, Sektorenübergreifende Gesundtheitsberichterstattung zur Kardiologie und Herzchirurgie in Deutschland. Mit vergleichenden Daten aus Österreich und anderen europäischen Staaten. Hannover Bruckenberger E (2007) Herzbericht 2006. 19. Bericht, Sektorenübergreifende Gesundtheitsberichterstattung zur Kardiologie und Herzchirurgie in Deutschland. Mit vergleichenden Daten aus Österreich und anderen europäischen Staaten. Hannover
7.
Zurück zum Zitat Cannon CP, Gibson CM, Lambrew CT et al. (2000) Relationship of symptom-onset-to-balloon time and door-to-balloon time with mortality in patients undergoing angioplasty for acute myocardial infarction. JAMA 283: 2941–2947PubMedCrossRef Cannon CP, Gibson CM, Lambrew CT et al. (2000) Relationship of symptom-onset-to-balloon time and door-to-balloon time with mortality in patients undergoing angioplasty for acute myocardial infarction. JAMA 283: 2941–2947PubMedCrossRef
8.
Zurück zum Zitat Cannon CP, Weintraub WS, Demopoulos LA et al. (1998) Invasive versus conservative strategies in unstable angina and non-Q-wave myocardial infarction following treatment with tirofiban: rationale and study design of the international TACTICS-TIMI 18 Trial. Treat Angina with aggrastat and determine cost of therapy with an invasive or conservative strategy. Thrombolysis in myocardial infarction. Am J Cardiol 82: 731–736PubMedCrossRef Cannon CP, Weintraub WS, Demopoulos LA et al. (1998) Invasive versus conservative strategies in unstable angina and non-Q-wave myocardial infarction following treatment with tirofiban: rationale and study design of the international TACTICS-TIMI 18 Trial. Treat Angina with aggrastat and determine cost of therapy with an invasive or conservative strategy. Thrombolysis in myocardial infarction. Am J Cardiol 82: 731–736PubMedCrossRef
9.
Zurück zum Zitat Cantor W, Fitchett D, Borgundvaag B et al. (2008) Trial of routine angioplasty and stenting after fibrinolysis to enhance reperfusion in acute myocardial infarction. The TRANSFER-AMI trial. ACC Meeting Cantor W, Fitchett D, Borgundvaag B et al. (2008) Trial of routine angioplasty and stenting after fibrinolysis to enhance reperfusion in acute myocardial infarction. The TRANSFER-AMI trial. ACC Meeting
10.
Zurück zum Zitat Collet JP, Montalescot G, Le MM et al. (2006) Percutaneous coronary intervention after fibrinolysis: a multiple meta-analyses approach according to the type of strategy. J Am Coll Cardiol 48: 1326–1335PubMedCrossRef Collet JP, Montalescot G, Le MM et al. (2006) Percutaneous coronary intervention after fibrinolysis: a multiple meta-analyses approach according to the type of strategy. J Am Coll Cardiol 48: 1326–1335PubMedCrossRef
11.
Zurück zum Zitat Winter RJ de, Windhausen F, Cornel JH et al. (2005) Early invasive versus selectively invasive management for acute coronary syndromes. N Engl J Med 353: 1095–1104PubMedCrossRef Winter RJ de, Windhausen F, Cornel JH et al. (2005) Early invasive versus selectively invasive management for acute coronary syndromes. N Engl J Med 353: 1095–1104PubMedCrossRef
12.
Zurück zum Zitat DeWood MA, Spores J, Notske R et al. (1980) Prevalence of total coronary occlusion during the early hours of transmural myocardial infarction. N Engl J Med 303: 897–902PubMed DeWood MA, Spores J, Notske R et al. (1980) Prevalence of total coronary occlusion during the early hours of transmural myocardial infarction. N Engl J Med 303: 897–902PubMed
13.
Zurück zum Zitat Di Mario C, Dudek D, Piscione F et al. (2008) Immediate angioplasty versus standard therapy with rescue angioplasty after thrombolysis in the Combined Abciximab REteplase Stent Study in Acute Myocardial Infarction (CARESS-in-AMI): an open, prospective, randomised, multicentre trial. Lancet 371: 559–568CrossRef Di Mario C, Dudek D, Piscione F et al. (2008) Immediate angioplasty versus standard therapy with rescue angioplasty after thrombolysis in the Combined Abciximab REteplase Stent Study in Acute Myocardial Infarction (CARESS-in-AMI): an open, prospective, randomised, multicentre trial. Lancet 371: 559–568CrossRef
14.
Zurück zum Zitat Ellis S for the FINESSE group (2007) Facilitated INtervention with Enhanced Reperfusion Speed to stop Events (FINESSE) trial. Annual ESC Meeting Ellis S for the FINESSE group (2007) Facilitated INtervention with Enhanced Reperfusion Speed to stop Events (FINESSE) trial. Annual ESC Meeting
15.
Zurück zum Zitat Ellis SG, Silva ER da, Heyndrickx G et al. (1994) Randomized comparison of rescue angioplasty with conservative management of patients with early failure of thrombolysis for acute anterior myocardial infarction. Circulation 90: 2280–2284PubMed Ellis SG, Silva ER da, Heyndrickx G et al. (1994) Randomized comparison of rescue angioplasty with conservative management of patients with early failure of thrombolysis for acute anterior myocardial infarction. Circulation 90: 2280–2284PubMed
16.
Zurück zum Zitat European Society of Cardiology, American College of Cardiology (2000) Myocardial infarction redefined – a consensus document of The Joint European Society of Cardiology/American College of Cardiology Committee for the redefinition of myocardial infarction. Eur Heart J 21: 1502–1513CrossRef European Society of Cardiology, American College of Cardiology (2000) Myocardial infarction redefined – a consensus document of The Joint European Society of Cardiology/American College of Cardiology Committee for the redefinition of myocardial infarction. Eur Heart J 21: 1502–1513CrossRef
17.
Zurück zum Zitat Fernandez-Aviles F, Alonso JJ, Castro-Beiras A et al. (2004) Routine invasive strategy within 24 hours of thrombolysis versus ischaemia-guided conservative approach for acute myocardial infarction with ST-segment elevation (GRACIA-1): a randomised controlled trial. Lancet 364: 1045–1053PubMedCrossRef Fernandez-Aviles F, Alonso JJ, Castro-Beiras A et al. (2004) Routine invasive strategy within 24 hours of thrombolysis versus ischaemia-guided conservative approach for acute myocardial infarction with ST-segment elevation (GRACIA-1): a randomised controlled trial. Lancet 364: 1045–1053PubMedCrossRef
18.
Zurück zum Zitat Fibrinolytic Therapy Trialists‘ (FTT) Collaborative Group (1994) Indications for fibrinolytic therapy in suspected acute myocardial infarction: collaborative overview of early mortality and major morbidity results from all randomised trials of more than 1000 patients. Lancet 343: 311–322 Fibrinolytic Therapy Trialists‘ (FTT) Collaborative Group (1994) Indications for fibrinolytic therapy in suspected acute myocardial infarction: collaborative overview of early mortality and major morbidity results from all randomised trials of more than 1000 patients. Lancet 343: 311–322
19.
Zurück zum Zitat Gibbons RJ, Holmes DR, Reeder GS et al. (1993) Immediate angioplasty compared with the administration of a thrombolytic agent followed by conservative treatment for myocardial infarction. The Mayo Coronary Care Unit and Catheterization Laboratory Groups. N Engl J Med 328: 685–691PubMedCrossRef Gibbons RJ, Holmes DR, Reeder GS et al. (1993) Immediate angioplasty compared with the administration of a thrombolytic agent followed by conservative treatment for myocardial infarction. The Mayo Coronary Care Unit and Catheterization Laboratory Groups. N Engl J Med 328: 685–691PubMedCrossRef
20.
Zurück zum Zitat Gibson CM, Cannon CP, Greene RM et al. (1997) Rescue angioplasty in the thrombolysis in myocardial infarction (TIMI) 4 trial. Am J Cardiol 80: 21–26PubMedCrossRef Gibson CM, Cannon CP, Greene RM et al. (1997) Rescue angioplasty in the thrombolysis in myocardial infarction (TIMI) 4 trial. Am J Cardiol 80: 21–26PubMedCrossRef
21.
Zurück zum Zitat Grassman ED, Johnson SA, Krone RJ (1997) Predictors of success and major complications for primary percutaneous transluminal coronary angioplasty in acute myocardial infarction. An analysis of the 1990 to 1994 Society for Cardiac Angiography and Interventions registries. J Am Coll Cardiol 30: 201–208PubMedCrossRef Grassman ED, Johnson SA, Krone RJ (1997) Predictors of success and major complications for primary percutaneous transluminal coronary angioplasty in acute myocardial infarction. An analysis of the 1990 to 1994 Society for Cardiac Angiography and Interventions registries. J Am Coll Cardiol 30: 201–208PubMedCrossRef
22.
Zurück zum Zitat Grines CL, Browne KF, Marco J et al. (1993) A comparison of immediate angioplasty with thrombolytic therapy for acute myocardial infarction. The Primary Angioplasty in Myocardial Infarction Study Group. N Engl J Med 328: 673–679PubMedCrossRef Grines CL, Browne KF, Marco J et al. (1993) A comparison of immediate angioplasty with thrombolytic therapy for acute myocardial infarction. The Primary Angioplasty in Myocardial Infarction Study Group. N Engl J Med 328: 673–679PubMedCrossRef
23.
Zurück zum Zitat Grines CL, Westerhausen DR, Grines LL et al. (2002) A randomized trial of transfer for primary angioplasty versus on-site thrombolysis in patients with high-risk myocardial infarction: the Air Primary Angioplasty in Myocardial Infarction study. J Am Coll Cardiol 39: 1713–1719PubMedCrossRef Grines CL, Westerhausen DR, Grines LL et al. (2002) A randomized trial of transfer for primary angioplasty versus on-site thrombolysis in patients with high-risk myocardial infarction: the Air Primary Angioplasty in Myocardial Infarction study. J Am Coll Cardiol 39: 1713–1719PubMedCrossRef
24.
Zurück zum Zitat Gruberg L, Di Segni E, Agranat O et al. (1998) Rescue coronary angiography after failed thrombolysis: a real-life experience. Cardiology 90: 48–51PubMedCrossRef Gruberg L, Di Segni E, Agranat O et al. (1998) Rescue coronary angiography after failed thrombolysis: a real-life experience. Cardiology 90: 48–51PubMedCrossRef
25.
Zurück zum Zitat Gruppo Italiano per lo Studio della Streptochinasi nell’Infarto Miocardico (GISSI) (1986) Effectiveness of intravenous thrombolytic treatment in acute myocardial infarction. Lancet 1: 397–402 Gruppo Italiano per lo Studio della Streptochinasi nell’Infarto Miocardico (GISSI) (1986) Effectiveness of intravenous thrombolytic treatment in acute myocardial infarction. Lancet 1: 397–402
26.
Zurück zum Zitat Gruppo Italiano per lo Studio della Streptochinasi nell’Infarto Miocardico (GISSI) (1987) Long-term effects of intravenous thrombolysis in acute myocardial infarction: final report of the GISSI study. Lancet 2: 871–874 Gruppo Italiano per lo Studio della Streptochinasi nell’Infarto Miocardico (GISSI) (1987) Long-term effects of intravenous thrombolysis in acute myocardial infarction: final report of the GISSI study. Lancet 2: 871–874
27.
Zurück zum Zitat Hamm CW, Arntz HR, Bode C et al. (2004) Leitlinien: Akutes Koronarsyndrom (ACS), Teil 1: Akutes Koronarsyndrom ohne ST-Hebung. Z Kardiol 93: 72–90PubMedCrossRef Hamm CW, Arntz HR, Bode C et al. (2004) Leitlinien: Akutes Koronarsyndrom (ACS), Teil 1: Akutes Koronarsyndrom ohne ST-Hebung. Z Kardiol 93: 72–90PubMedCrossRef
28.
Zurück zum Zitat Hamm CW, Arntz HR, Bode C et al. (2004) Leitlinien: Akutes Koronarsyndrom (ACS), Teil 2: Akutes Koronarsyndrom mit ST-Hebung. Z Kardiol 93: 324–341PubMedCrossRef Hamm CW, Arntz HR, Bode C et al. (2004) Leitlinien: Akutes Koronarsyndrom (ACS), Teil 2: Akutes Koronarsyndrom mit ST-Hebung. Z Kardiol 93: 324–341PubMedCrossRef
29.
Zurück zum Zitat Keeley EC, Boura JA, Grines CL (2003) Primary angioplasty versus intravenous thrombolytic therapy for acute myocardial infarction: a quantitative review of 23 randomised trials. Lancet 361: 13–20PubMedCrossRef Keeley EC, Boura JA, Grines CL (2003) Primary angioplasty versus intravenous thrombolytic therapy for acute myocardial infarction: a quantitative review of 23 randomised trials. Lancet 361: 13–20PubMedCrossRef
30.
Zurück zum Zitat Keeley EC, Boura JA, Grines CL (2006) Comparison of primary and facilitated percutaneous coronary interventions for ST-elevation myocardial infarction: quantitative review of randomised trials. Lancet 367: 579–588PubMedCrossRef Keeley EC, Boura JA, Grines CL (2006) Comparison of primary and facilitated percutaneous coronary interventions for ST-elevation myocardial infarction: quantitative review of randomised trials. Lancet 367: 579–588PubMedCrossRef
31.
Zurück zum Zitat Le May MR, Wells GA, Labinaz M et al. (2005) Combined angioplasty and pharmacological intervention versus thrombolysis alone in acute myocardial infarction (CAPITAL AMI study). J Am Coll Cardiol 46: 417–424CrossRef Le May MR, Wells GA, Labinaz M et al. (2005) Combined angioplasty and pharmacological intervention versus thrombolysis alone in acute myocardial infarction (CAPITAL AMI study). J Am Coll Cardiol 46: 417–424CrossRef
32.
Zurück zum Zitat Montalescot G, Borentain M, Payot L et al. (2004) Early vs late administration of glycoprotein IIb/IIIa inhibitors in primary percutaneous coronary intervention of acute ST-segment elevation myocardial infarction: a meta-analysis. JAMA 292: 362–366PubMedCrossRef Montalescot G, Borentain M, Payot L et al. (2004) Early vs late administration of glycoprotein IIb/IIIa inhibitors in primary percutaneous coronary intervention of acute ST-segment elevation myocardial infarction: a meta-analysis. JAMA 292: 362–366PubMedCrossRef
33.
Zurück zum Zitat Nallamothu BK, Bates ER (2003) Percutaneous coronary intervention versus fibrinolytic therapy in acute myocardial infarction: is timing (almost) everything? Am J Cardiol 92: 824–826PubMedCrossRef Nallamothu BK, Bates ER (2003) Percutaneous coronary intervention versus fibrinolytic therapy in acute myocardial infarction: is timing (almost) everything? Am J Cardiol 92: 824–826PubMedCrossRef
34.
Zurück zum Zitat Neumann FJ, Kastrati A, Pogatsa-Murray G et al. (2003) Evaluation of prolonged antithrombotic pretreatment („cooling-off“ strategy) before intervention in patients with unstable coronary syndromes: a randomized controlled trial. JAMA 290: 1593–1599PubMedCrossRef Neumann FJ, Kastrati A, Pogatsa-Murray G et al. (2003) Evaluation of prolonged antithrombotic pretreatment („cooling-off“ strategy) before intervention in patients with unstable coronary syndromes: a randomized controlled trial. JAMA 290: 1593–1599PubMedCrossRef
35.
Zurück zum Zitat Nunn CM, O’Neill WW, Rothbaum D et al. (1999) Long-term outcome after primary angioplasty: report from the primary angioplasty in myocardial infarction (PAMI-I) trial. J Am Coll Cardiol 33: 640–646PubMedCrossRef Nunn CM, O’Neill WW, Rothbaum D et al. (1999) Long-term outcome after primary angioplasty: report from the primary angioplasty in myocardial infarction (PAMI-I) trial. J Am Coll Cardiol 33: 640–646PubMedCrossRef
36.
Zurück zum Zitat O’Neill W, Timmis GC, Bourdillon PD et al. (1986) A prospective randomized clinical trial of intracoronary streptokinase versus coronary angioplasty for acute myocardial infarction. N Engl J Med 314: 812–818 O’Neill W, Timmis GC, Bourdillon PD et al. (1986) A prospective randomized clinical trial of intracoronary streptokinase versus coronary angioplasty for acute myocardial infarction. N Engl J Med 314: 812–818
37.
Zurück zum Zitat Ribeiro EE, Silva LA, Carneiro R et al. (1993) Randomized trial of direct coronary angioplasty versus intravenous streptokinase in acute myocardial infarction. J Am Coll Cardiol 22: 376–380PubMedCrossRef Ribeiro EE, Silva LA, Carneiro R et al. (1993) Randomized trial of direct coronary angioplasty versus intravenous streptokinase in acute myocardial infarction. J Am Coll Cardiol 22: 376–380PubMedCrossRef
38.
Zurück zum Zitat Ross AM, Coyne KS, Reiner JS et al. (1999) A randomized trial comparing primary angioplasty with a strategy of short-acting thrombolysis and immediate planned rescue angioplasty in acute myocardial infarction: the PACT trial. PACT investigators. Plasminogen-activator Angioplasty Compatibility Trial. J Am Coll Cardiol 34: 1954–1962PubMedCrossRef Ross AM, Coyne KS, Reiner JS et al. (1999) A randomized trial comparing primary angioplasty with a strategy of short-acting thrombolysis and immediate planned rescue angioplasty in acute myocardial infarction: the PACT trial. PACT investigators. Plasminogen-activator Angioplasty Compatibility Trial. J Am Coll Cardiol 34: 1954–1962PubMedCrossRef
39.
Zurück zum Zitat Scheller B, Hennen B, Hammer B et al. (2003) Beneficial effects of immediate stenting after thrombolysis in acute myocardial infarction. J Am Coll Cardiol 42: 634–641PubMedCrossRef Scheller B, Hennen B, Hammer B et al. (2003) Beneficial effects of immediate stenting after thrombolysis in acute myocardial infarction. J Am Coll Cardiol 42: 634–641PubMedCrossRef
40.
Zurück zum Zitat Schömig A, Kastrati A, Dirschinger J et al. (2000) Coronary stenting plus platelet glycoprotein IIb/IIIa blockade compared with tissue plasminogen activator in acute myocardial infarction. Stent versus Thrombolysis for Occluded Coronary Arteries in Patients with Acute Myocardial Infarction Study Investigators. N Engl J Med 343: 385–391PubMedCrossRef Schömig A, Kastrati A, Dirschinger J et al. (2000) Coronary stenting plus platelet glycoprotein IIb/IIIa blockade compared with tissue plasminogen activator in acute myocardial infarction. Stent versus Thrombolysis for Occluded Coronary Arteries in Patients with Acute Myocardial Infarction Study Investigators. N Engl J Med 343: 385–391PubMedCrossRef
41.
Zurück zum Zitat Schömig A, Mehilli J, Antoniucci D et al. (2005) Mechanical reperfusion in patients with acute myocardial infarction presenting more than 12 hours from symptom onset: a randomized controlled trial. JAMA 293: 2865–2872PubMedCrossRef Schömig A, Mehilli J, Antoniucci D et al. (2005) Mechanical reperfusion in patients with acute myocardial infarction presenting more than 12 hours from symptom onset: a randomized controlled trial. JAMA 293: 2865–2872PubMedCrossRef
42.
Zurück zum Zitat Spacek R, Widimsky P, Straka Z et al. (2002) Value of first day angiography/angioplasty in evolving Non-ST segment elevation myocardial infarction: an open multicenter randomized trial. The VINO Study. Eur Heart J 23: 230–238PubMedCrossRef Spacek R, Widimsky P, Straka Z et al. (2002) Value of first day angiography/angioplasty in evolving Non-ST segment elevation myocardial infarction: an open multicenter randomized trial. The VINO Study. Eur Heart J 23: 230–238PubMedCrossRef
43.
Zurück zum Zitat The FRISC II Investigators (1999) Invasive compared with non-invasive treatment in unstable coronary-artery disease: FRISC II prospective randomised multicentre study. FRagmin and Fast Revascularisation during InStability in Coronary artery disease Investigators. Lancet 354: 708–715CrossRef The FRISC II Investigators (1999) Invasive compared with non-invasive treatment in unstable coronary-artery disease: FRISC II prospective randomised multicentre study. FRagmin and Fast Revascularisation during InStability in Coronary artery disease Investigators. Lancet 354: 708–715CrossRef
44.
Zurück zum Zitat The Global Use of Strategies to Open Occluded Coronary Arteries in Acute Coronary Syndromes (GUSTO IIb) Angioplasty Substudy Investigators (1997) A clinical trial comparing primary coronary angioplasty with tissue plasminogen activator for acute myocardial infarction. N Engl J Med 336: 1621–1628CrossRef The Global Use of Strategies to Open Occluded Coronary Arteries in Acute Coronary Syndromes (GUSTO IIb) Angioplasty Substudy Investigators (1997) A clinical trial comparing primary coronary angioplasty with tissue plasminogen activator for acute myocardial infarction. N Engl J Med 336: 1621–1628CrossRef
45.
Zurück zum Zitat The TIMI IIIB Investigators (1994) Effects of tissue plasminogen activator and a comparison of early invasive and conservative strategies in unstable angina and non-Q-wave myocardial infarction. Results of the TIMI IIIB Trial. Thrombolysis in Myocardial Ischemia. Circulation 89: 1545–1556 The TIMI IIIB Investigators (1994) Effects of tissue plasminogen activator and a comparison of early invasive and conservative strategies in unstable angina and non-Q-wave myocardial infarction. Results of the TIMI IIIB Trial. Thrombolysis in Myocardial Ischemia. Circulation 89: 1545–1556
46.
Zurück zum Zitat Thygesen K, Alpert JS, White HD (2007) Universal definition of myocardial infarction. Eur Heart J 28: 2525–2538PubMedCrossRef Thygesen K, Alpert JS, White HD (2007) Universal definition of myocardial infarction. Eur Heart J 28: 2525–2538PubMedCrossRef
47.
Zurück zum Zitat Vermeer F, Ophuis AJ, Berg EJ et al. (1999) Prospective randomised comparison between thrombolysis, rescue PTCA, and primary PTCA in patients with extensive myocardial infarction admitted to a hospital without PTCA facilities: a safety and feasibility study. Heart 82: 426–431PubMed Vermeer F, Ophuis AJ, Berg EJ et al. (1999) Prospective randomised comparison between thrombolysis, rescue PTCA, and primary PTCA in patients with extensive myocardial infarction admitted to a hospital without PTCA facilities: a safety and feasibility study. Heart 82: 426–431PubMed
48.
Zurück zum Zitat Widimsky P, Budesinsky T, Vorac D et al. (2003) Long distance transport for primary angioplasty vs immediate thrombolysis in acute myocardial infarction. Final results of the randomized national multicentre trial–PRAGUE-2. Eur Heart J 24: 94–104PubMedCrossRef Widimsky P, Budesinsky T, Vorac D et al. (2003) Long distance transport for primary angioplasty vs immediate thrombolysis in acute myocardial infarction. Final results of the randomized national multicentre trial–PRAGUE-2. Eur Heart J 24: 94–104PubMedCrossRef
49.
Zurück zum Zitat Widimsky P, Groch L, Zelizko M et al. (2000) Multicentre randomized trial comparing transport to primary angioplasty vs immediate thrombolysis vs combined strategy for patients with acute myocardial infarction presenting to a community hospital without a catheterization laboratory. The PRAGUE Study. Eur Heart J 21: 823–831PubMedCrossRef Widimsky P, Groch L, Zelizko M et al. (2000) Multicentre randomized trial comparing transport to primary angioplasty vs immediate thrombolysis vs combined strategy for patients with acute myocardial infarction presenting to a community hospital without a catheterization laboratory. The PRAGUE Study. Eur Heart J 21: 823–831PubMedCrossRef
50.
Zurück zum Zitat Zahn R, Gottwik M, Hochadel M et al. (2008) Volume-outcome relation for contemporary percutaneous coronary interventions (PCI) in daily clinical practice: is it limited to high-risk patients? Results from the Registry of Percutaneous Coronary Interventions of the Arbeitsgemeinschaft Leitende Kardiologische Krankenhausärzte (ALKK). Heart 94: 329–335PubMedCrossRef Zahn R, Gottwik M, Hochadel M et al. (2008) Volume-outcome relation for contemporary percutaneous coronary interventions (PCI) in daily clinical practice: is it limited to high-risk patients? Results from the Registry of Percutaneous Coronary Interventions of the Arbeitsgemeinschaft Leitende Kardiologische Krankenhausärzte (ALKK). Heart 94: 329–335PubMedCrossRef
51.
Zurück zum Zitat Zahn R, Schiele R, Schneider S et al. (2002) Long-term follow-up of patients with acute myocardial infarction treated with primary angioplasty or thrombolysis. Results of the MITRA trial. Z Kardiol 91: 49–57CrossRef Zahn R, Schiele R, Schneider S et al. (2002) Long-term follow-up of patients with acute myocardial infarction treated with primary angioplasty or thrombolysis. Results of the MITRA trial. Z Kardiol 91: 49–57CrossRef
52.
Zurück zum Zitat Zahn R, Vogt A, Seidl K et al. (1997) Ballondilatation beim akuten Herzinfarkt im klinischen Alltag: Ergebnisse des Registers der Arbeitsgemeinschaft Leitender Kardiologischer Krankenhausarzte (ALKK) bei 4625 Patienten. Z Kardiol 86: 712–721PubMedCrossRef Zahn R, Vogt A, Seidl K et al. (1997) Ballondilatation beim akuten Herzinfarkt im klinischen Alltag: Ergebnisse des Registers der Arbeitsgemeinschaft Leitender Kardiologischer Krankenhausarzte (ALKK) bei 4625 Patienten. Z Kardiol 86: 712–721PubMedCrossRef
53.
Zurück zum Zitat Zeymer U, Gitt A, Zahn R et al. (2007) Frühe Reperfusionstherapie beim Myokardinfarkt im klinischen Alltag. Ergebnisse aus dem MITRA-Plus-Register. Dtsch Arztebl 104: 2133–2137 Zeymer U, Gitt A, Zahn R et al. (2007) Frühe Reperfusionstherapie beim Myokardinfarkt im klinischen Alltag. Ergebnisse aus dem MITRA-Plus-Register. Dtsch Arztebl 104: 2133–2137
54.
Zurück zum Zitat Zijlstra F, Boer MJ de, Hoorntje JC et al. (1993) A comparison of immediate coronary angioplasty with intravenous streptokinase in acute myocardial infarction. N Engl J Med 328: 680–684PubMedCrossRef Zijlstra F, Boer MJ de, Hoorntje JC et al. (1993) A comparison of immediate coronary angioplasty with intravenous streptokinase in acute myocardial infarction. N Engl J Med 328: 680–684PubMedCrossRef
55.
Zurück zum Zitat Zijlstra F, Hoorntje JC, Boer MJ de et al. (1999) Long-term benefit of primary angioplasty as compared with thrombolytic therapy for acute myocardial infarction. N Engl J Med 341: 1413–1419PubMedCrossRef Zijlstra F, Hoorntje JC, Boer MJ de et al. (1999) Long-term benefit of primary angioplasty as compared with thrombolytic therapy for acute myocardial infarction. N Engl J Med 341: 1413–1419PubMedCrossRef
Metadaten
Titel
Interventionelle Therapie des akuten Herzinfarkts
verfasst von
Prof. Dr. R. Zahn
U. Zeymer
Publikationsdatum
01.09.2008
Verlag
Springer-Verlag
Erschienen in
Die Innere Medizin / Ausgabe 9/2008
Print ISSN: 2731-7080
Elektronische ISSN: 2731-7099
DOI
https://doi.org/10.1007/s00108-008-2075-2

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