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Erschienen in: Supportive Care in Cancer 7/2006

01.07.2006 | Review Article

Intestinal mucositis: the role of the Bcl-2 family, p53 and caspases in chemotherapy-induced damage

verfasst von: Joanne M. Bowen, Rachel J. Gibson, Adrian G. Cummins, Dorothy M. K. Keefe

Erschienen in: Supportive Care in Cancer | Ausgabe 7/2006

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Abstract

Intestinal mucositis occurs as a consequence of cytotoxic treatment through multiple mechanisms including induction of crypt cell death (apoptosis) and cytostasis. The molecular control of these actions throughout the gastrointestinal tract has yet to be fully elucidated; however, they are known to involve p53, the Bcl-2 family and caspases. This review will provide an overview of current research as well as identify areas where gaps in knowledge exist.
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Metadaten
Titel
Intestinal mucositis: the role of the Bcl-2 family, p53 and caspases in chemotherapy-induced damage
verfasst von
Joanne M. Bowen
Rachel J. Gibson
Adrian G. Cummins
Dorothy M. K. Keefe
Publikationsdatum
01.07.2006
Verlag
Springer-Verlag
Erschienen in
Supportive Care in Cancer / Ausgabe 7/2006
Print ISSN: 0941-4355
Elektronische ISSN: 1433-7339
DOI
https://doi.org/10.1007/s00520-005-0004-7

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