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30.10.2017 | Original Article

Intra- and inter-serotypic recombinations in the 5΄ UTR-VP4 region of Echovirus 30 strains

verfasst von: Zaharoula Kyriakopoulou, Grigoris D. Amoutzias, Tilemachos G. Dimitriou, Dimitris Tsakogiannis, Dimitris Mossialos, Panayotis Markoulatos

Erschienen in: Archives of Virology | Ausgabe 2/2018

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Abstract

Recombination has been recognized as a major mechanism of evolution in enteroviruses. The Echovirus 30 (E-30) strain Gior was sequenced and phylogenetically compared to all available E-30 sequences to detect recombination events between the 5΄UTR and VP1 genomic regions. The comparison of phylogenetic trees of the 5΄UTR and VP1 revealed incongruences concerning strains, lineages and sub-lineages. Comparative analysis of 62 E-30 sub-genomic sequences revealed six different recombination events that almost all occurred in the same region, having a start point in the 3΄end of the 5΄ UTR and end point in VP4. The only exception was the sub-lineage of Gior for which both borders of recombination were located in the 5΄UTR. These results describe for the first time recombination events in this region in circulating EV-B strains, revealing the exact points of these recombination events, highlighting the impact of such events on the evolution and epidemiology of enteroviruses.

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Titel: Intra- and inter-serotypic recombinations in the 5΄ UTR-VP4 region of Echovirus 30 strains
verfasst von: Zaharoula Kyriakopoulou
Grigoris D. Amoutzias
Tilemachos G. Dimitriou
Dimitris Tsakogiannis
Dimitris Mossialos
Panayotis Markoulatos
Publikationsdatum: 30.10.2017
Verlag: Springer Vienna
Erschienen in: Archives of Virology / Ausgabe 2/2018
Print ISSN: 0304-8608
Elektronische ISSN: 1432-8798
DOI: https://doi.org/10.1007/s00705-017-3600-1

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Intra- and inter-serotypic recombinations in the 5΄ UTR-VP4 region of Echovirus 30 strains

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