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18.10.2017 | 2017 SSAT Plenary Presentation | Ausgabe 2/2018

Journal of Gastrointestinal Surgery 2/2018

Intraductal Papillary Mucinous Neoplasm of the Pancreas in Young Patients: Tumor Biology, Clinical Features, and Survival Outcomes

Journal of Gastrointestinal Surgery > Ausgabe 2/2018
Vicente Morales-Oyarvide, Mari Mino-Kenudson, Cristina R. Ferrone, Andrew L. Warshaw, Keith D. Lillemoe, Dushyant V. Sahani, Ilaria Pergolini, Marc A. Attiyeh, Mohammad Al Efishat, Neda Rezaee, Ralph H. Hruban, Jin He, Matthew J. Weiss, Peter J. Allen, Christopher L. Wolfgang, Carlos Fernández-del Castillo
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Electronic supplementary material

The online version of this article (https://​doi.​org/​10.​1007/​s11605-017-3602-z) contains supplementary material, which is available to authorized users.
Presented at the Society for Surgery of the Alimentary Tract (SSAT) Plenary Session at the Digestive Disease Week 2018 on May 7th, 2017 in Chicago, IL.



The aim of this paper is to describe the characteristics of intraductal papillary mucinous neoplasms (IPMNs) of the pancreas in young patients.


We evaluated 1693 patients from the Pancreatic Surgery Consortium who underwent resection for IPMN and classified them as younger or older than 50 years of age at the time of surgery. We assessed the relationship of age with clinical, radiological, pathological, and prognostic features.


We identified 90 (5%) young patients. Age was not associated with differences in main pancreatic duct size (P = 0.323), presence of solid components (P = 0.805), or cyst size (P = 0.135). IPMNs from young patients were less likely to be of gastric type (37 vs. 57%, P = 0.005), and more likely to be of oncocytic (15 vs. 4%, P = 0.003) and intestinal types (44 vs. 26%, P = 0.004). Invasive carcinomas arising from IPMN were less common in young patients (17 vs. 27%, P = 0.044), and when present they were commonly of colloid type (47 vs. 31% in older patients, P = 0.261) and had better overall survival than older patients (5-year, 71 vs. 37%, log-rank P = 0.031).


Resection for IPMN is infrequent in young patients, but when they are resected, IPMNs from young patients demonstrate different epithelial subtypes from those in older patients and more favorable prognosis.

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