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01.12.2011 | Case report | Ausgabe 1/2011 Open Access

Journal of Medical Case Reports 1/2011

Intrathecal injection of human umbilical cord blood-derived mesenchymal stem cells for the treatment of basilar artery dissection: a case report

Journal of Medical Case Reports > Ausgabe 1/2011
Hoon Han, Sang-Keun Chang, Jennifer J Chang, Soo-Han Hwang, Seung-Hyup Han, Bok-Hwan Chun
Wichtige Hinweise

Electronic supplementary material

The online version of this article (doi:10.​1186/​1752-1947-5-562) contains supplementary material, which is available to authorized users.

Competing interests

The authors declare that they have no competing interests. HH is the founder of Histostem in Korea, established in 2000. S-HHw, S-HHa and B-HC are staff of Histostem. JJC is a visiting doctor who works at Histostem. S-KC is a professor at the Department of Neurosurgery, Konkuk University Hospital, Seoul, Korea, and has no financial connection with Histostem.

Authors' contributions

All authors read and approved the final manuscript. HH was involved in drafting the data from our patient, and analyzed the data regarding the disease process. S-HHw, S-HHa and B-HC contributed to the preparation of hUCB-derived MSC. JJC was the attending medical doctor who made a substantial contribution to the analysis of data. S-KC performed the intrathecal injection of hUCB-derived MSC given to our patient.



Basilar artery dissection is a rare occurrence, and is significantly associated with morbidity and mortality. To the best of our knowledge, we report the first case of basilar artery dissection treated with mesenchymal stem cells.

Case presentation

We present the case of a 17-year-old Korean man who was diagnosed with basilar artery dissection. Infarction of the bilateral pons, midbrain and right superior cerebellum due to his basilar artery dissection was partially recanalized by intrathecal injection of human umbilical cord blood-derived mesenchymal stem cells. No immunosuppressants were given to our patient, and human leukocyte antigen alloantibodies were not detected after cell therapy.


This case indicates that intrathecal injections of mesenchymal stem cells can be used in the treatment of basilar artery dissection.

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