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Cancer Immunology, Immunotherapy

Erschienen in:

01.07.2015 | Focussed Research Review

Intratumoral immunotherapy for melanoma

verfasst von: Manisha Singh, Willem W. Overwijk

Erschienen in: Cancer Immunology, Immunotherapy | Ausgabe 7/2015

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Abstract

Selection of suitable tumor-associated antigens is a major challenge in the development of effective cancer vaccines. Intratumoral (i.t.) immunotherapy empowers the immune system to mount T cell responses against tumor-associated antigens which are most immunogenic. To mediate systemic tumor regression, i.t. immunotherapy must generate systemic T cell responses that can target distant metastases beyond the initially treated tumor mass. Now that promising preclinical results and some initial success in clinical trials have been obtained, we here review i.t. immunotherapy-related preclinical and clinical studies, their mechanisms of action and future prospects.

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Titel: Intratumoral immunotherapy for melanoma
verfasst von: Manisha Singh
Willem W. Overwijk
Publikationsdatum: 01.07.2015
Verlag: Springer Berlin Heidelberg
Erschienen in: Cancer Immunology, Immunotherapy / Ausgabe 7/2015
Print ISSN: 0340-7004
Elektronische ISSN: 1432-0851
DOI: https://doi.org/10.1007/s00262-015-1727-z

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24.04.2024 | DGIM 2024 | Nachrichten

Springer Medizin

Intratumoral immunotherapy for melanoma

Abstract

Neu im Fachgebiet Onkologie

Bei Senioren mit Prostatakarzinom auf Anämie achten!

ICI-Therapie in der Schwangerschaft wird gut toleriert

Krebspatienten impfen: Was? Wen? Und wann nicht?

Müde im Alter? Auch an die Nebenniere denken

Update Onkologie

Springer Medizin

Abstract

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