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01.09.2009 | Case Report | Ausgabe 9/2009

Graefe's Archive for Clinical and Experimental Ophthalmology 9/2009

Intravitreal ranibizumab for choroidal neovascularization related to traumatic Bruch’s membrane rupture

Graefe's Archive for Clinical and Experimental Ophthalmology > Ausgabe 9/2009
Feng Liang, Nathalie Puche, Gisèle Soubrane, Eric H. Souied
Wichtige Hinweise
The authors have no proprietary interest in the materials used in this study.



Choroidal neovascularization (CNV) secondary to traumatic rupture of Bruch’s membrane is a rare condition, without standardized treatment. Here we describe one case of CNV related to traumatic rupture of Bruch’s membrane which was successfully treated with intravitreal injection of ranibizumab.


A 14-year-old patient was referred for ocular contusion, complicating interpapillomacular rupture of Bruch’s membrane in left eye. Indeed, a correct initial visual acuity, juxtafoveolar CNV appeared 4 months later on the border of Bruch’s membrane rupture. The patient was treated with an off-label intravitreal ranibizumab because of worsening of visual acuity.


One month after intravitreal injection, visual acuity improved, from 20/40 to 20/25. At 12-month follow-up, visual acuity remained at 20/25, fundus examination. Fluorescein angiography, indocyanine green angiography and optic coherence tomography showed fibrotic evolution of CNV. The Bruch’s membrane rupture remained stable. No side-effect of intravitreal injection of ranibizumab was observed.


For this patient affected with CNV secondary to traumatic Bruch’s membrane, one single intravitreal ranibizumab injection was efficient, with 1-year follow-up.

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