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Erschienen in: Supportive Care in Cancer 11/2018

18.05.2018 | Original Article

Investigating the prognostic ability of health-related quality of life on survival: a prospective cohort study of adults with lung cancer

verfasst von: Laura C. Pinheiro, Bryce B. Reeve

Erschienen in: Supportive Care in Cancer | Ausgabe 11/2018

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Abstract

Background

Health-related quality of life (HRQOL) is an important predictor for overall survival (OS). To date, no studies compared associations between HRQOL assessed before and after a cancer diagnosis for OS. Our objectives were to (1) investigate associations between HRQOL changes and OS and (2) identify the best HRQOL assessment time point to predict OS.

Methods

We used the Surveillance, Epidemiology and End Results linked with the Medicare Health Outcomes Survey data. Medicare Advantage beneficiaries with SEER-confirmed, incident lung cancer between 1998 and 2013 were included. We only included individuals who completed pre- and post-diagnosis assessments. HRQOL was captured using the Short-Form (SF-36) and Katz’s Activities of Daily Living (ADL). Cox Proportional Hazards models examined associations between HRQOL and OS, adjusting for potential confounders. AICs compared model fit.

Results

Five hundred thirty-five adults with mean age of 75 years at diagnosis were included. We observed 300 deaths. Poor HRQOL was associated with greater risk of death across HRQOL assessments. SF-36 before diagnosis, after diagnosis, and change over time had AHRs of 1.01–1.08, 1.10–1.20, and 1.06–1.12, respectively. Pre-diagnosis, post-diagnosis, and changes in ADLs had AHRs of 0.90–2.06, 1.72–2.56, and 1.66–2.21, respectively. Post-diagnosis HRQOL and HRQOL change models had the smallest AICs and largest AHRs, suggesting they were most associated with OS.

Conclusions

This is the first study to compare the prognostic ability of pre-diagnosis, post-diagnosis, and HRQOL changes for OS. The prognostic value of HRQOL at distinct points in the cancer continuum underscores the importance of routine HRQOL monitoring as part of patient-centered cancer care.
Literatur
1.
Zurück zum Zitat Ferlay J, Shin HR, Bray F, Forman D, Mathers C, Parkin DM (2010) Estimates of worldwide burden of cancer in 2008: GLOBOCAN 2008. Int J Cancer 127(12):2893–2917CrossRef Ferlay J, Shin HR, Bray F, Forman D, Mathers C, Parkin DM (2010) Estimates of worldwide burden of cancer in 2008: GLOBOCAN 2008. Int J Cancer 127(12):2893–2917CrossRef
3.
Zurück zum Zitat Claassens L, van Meerbeeck J, Coens C, Quinten C, Ghislain I, Sloan EK, Wang XS, Velikova G, Bottomley A (2011) Health-related quality of life in non-small-cell lung cancer: an update of a systematic review on methodologic issues in randomized controlled trials. J Clin Oncol 29(15):2104–2120CrossRef Claassens L, van Meerbeeck J, Coens C, Quinten C, Ghislain I, Sloan EK, Wang XS, Velikova G, Bottomley A (2011) Health-related quality of life in non-small-cell lung cancer: an update of a systematic review on methodologic issues in randomized controlled trials. J Clin Oncol 29(15):2104–2120CrossRef
4.
Zurück zum Zitat Donovan K, Sanson-Fisher RW, Redman S (1989) Measuring quality of life in cancer patients. J Clin Oncol 7(7):959–968CrossRef Donovan K, Sanson-Fisher RW, Redman S (1989) Measuring quality of life in cancer patients. J Clin Oncol 7(7):959–968CrossRef
5.
Zurück zum Zitat Hennessy CH, Moriarty DG, Zack MM, Scherr PA, Brackbill R (1994) Measuring health-related quality of life for public health surveillance. Public health Rep (Washington, DC: 1974) 109(5):665–672 Hennessy CH, Moriarty DG, Zack MM, Scherr PA, Brackbill R (1994) Measuring health-related quality of life for public health surveillance. Public health Rep (Washington, DC: 1974) 109(5):665–672
6.
Zurück zum Zitat Gotay CC, Kawamoto CT, Bottomley A, Efficace F (2008) The prognostic significance of patient-reported outcomes in cancer clinical trials. J Clin Oncol 26(8):1355–1363CrossRef Gotay CC, Kawamoto CT, Bottomley A, Efficace F (2008) The prognostic significance of patient-reported outcomes in cancer clinical trials. J Clin Oncol 26(8):1355–1363CrossRef
7.
Zurück zum Zitat Ganz PA, Lee JJ, Siau J (1991) Quality of life assessment. An independent prognostic variable for survival in lung cancer. Cancer 67(12):3131–3135CrossRef Ganz PA, Lee JJ, Siau J (1991) Quality of life assessment. An independent prognostic variable for survival in lung cancer. Cancer 67(12):3131–3135CrossRef
8.
Zurück zum Zitat Pinheiro LC, Zagar TM, Reeve BB (2017) The prognostic value of pre-diagnosis health-related quality of life on survival: a prospective cohort study of older Americans with lung cancer. Qual Life Res Int J Qual Life Asp Treat Care Rehab 26:1703–1712 Pinheiro LC, Zagar TM, Reeve BB (2017) The prognostic value of pre-diagnosis health-related quality of life on survival: a prospective cohort study of older Americans with lung cancer. Qual Life Res Int J Qual Life Asp Treat Care Rehab 26:1703–1712
9.
Zurück zum Zitat Ambs A, Warren JL, Bellizzi KM, Topor M, Haffer SC, Clauser SB (2008) Overview of the SEER—Medicare Health Outcomes Survey linked dataset. Health Care Financ Rev 29(4):5–21PubMedPubMedCentral Ambs A, Warren JL, Bellizzi KM, Topor M, Haffer SC, Clauser SB (2008) Overview of the SEER—Medicare Health Outcomes Survey linked dataset. Health Care Financ Rev 29(4):5–21PubMedPubMedCentral
10.
Zurück zum Zitat Ware JE Jr, Sherbourne CD (1992) The MOS 36-item short-form health survey (SF-36). I. Conceptual framework and item selection. Med Care 30(6):473–483CrossRef Ware JE Jr, Sherbourne CD (1992) The MOS 36-item short-form health survey (SF-36). I. Conceptual framework and item selection. Med Care 30(6):473–483CrossRef
11.
Zurück zum Zitat Fleishman JA, Selim AJ, Kazis LE (2010) Deriving SF-12v2 physical and mental health summary scores: a comparison of different scoring algorithms. Qual Life Res Int J Qual Life Asp Treat Care Rehab 19(2):231–241 Fleishman JA, Selim AJ, Kazis LE (2010) Deriving SF-12v2 physical and mental health summary scores: a comparison of different scoring algorithms. Qual Life Res Int J Qual Life Asp Treat Care Rehab 19(2):231–241
12.
Zurück zum Zitat Selim A, Rogers W, Qian S, Rothendler JA, Kent EE, Kazis LE (2016) A New algorithm to build bridges between two patient-reported health outcome instruments: the MOS SF-36® and the VR-12 Health Survey. National Cancer Institute Selim A, Rogers W, Qian S, Rothendler JA, Kent EE, Kazis LE (2016) A New algorithm to build bridges between two patient-reported health outcome instruments: the MOS SF-36® and the VR-12 Health Survey. National Cancer Institute
14.
Zurück zum Zitat Cohen J (1965) Some statistical issues in psychological research. Handbook of clinical psychology. McGraw-Hill, New York, pp 95–121 Cohen J (1965) Some statistical issues in psychological research. Handbook of clinical psychology. McGraw-Hill, New York, pp 95–121
15.
Zurück zum Zitat Katz S (1983) Assessing self-maintenance: activities of daily living, mobility, and instrumental activities of daily living. J Am Geriatr Soc 31(12):721–727CrossRef Katz S (1983) Assessing self-maintenance: activities of daily living, mobility, and instrumental activities of daily living. J Am Geriatr Soc 31(12):721–727CrossRef
16.
Zurück zum Zitat Concato J, Peduzzi P, Holford TR, Feinstein AR (1995) Importance of events per independent variable in proportional hazards analysis. I. Background, goals, and general strategy. J Clin Epidemiol 48(12):1495–1501CrossRef Concato J, Peduzzi P, Holford TR, Feinstein AR (1995) Importance of events per independent variable in proportional hazards analysis. I. Background, goals, and general strategy. J Clin Epidemiol 48(12):1495–1501CrossRef
17.
Zurück zum Zitat Bozdogan H (1987) Model selection and Akaike’s information criterion (AIC): the general theory and its analytical extensions. Psychometrika 52:345–370CrossRef Bozdogan H (1987) Model selection and Akaike’s information criterion (AIC): the general theory and its analytical extensions. Psychometrika 52:345–370CrossRef
18.
Zurück zum Zitat Duijts SF, van Egmond MP, Spelten E, van Muijen P, Anema JR, van der Beek AJ (2014) Physical and psychosocial problems in cancer survivors beyond return to work: a systematic review. Psycho-Oncology 23(5):481–492CrossRef Duijts SF, van Egmond MP, Spelten E, van Muijen P, Anema JR, van der Beek AJ (2014) Physical and psychosocial problems in cancer survivors beyond return to work: a systematic review. Psycho-Oncology 23(5):481–492CrossRef
19.
Zurück zum Zitat Dickens AP, Richards SH, Greaves CJ, Campbell JL (2011) Interventions targeting social isolation in older people: a systematic review. BMC Public Health 11:647CrossRef Dickens AP, Richards SH, Greaves CJ, Campbell JL (2011) Interventions targeting social isolation in older people: a systematic review. BMC Public Health 11:647CrossRef
20.
Zurück zum Zitat Reeve BB, Potosky AL, Smith AW, Han PK, Hays RD, Davis WW, Arora NK, Haffer SC, Clauser SB (2009) Impact of cancer on health-related quality of life of older Americans. J Natl Cancer Inst 101(12):860–868CrossRef Reeve BB, Potosky AL, Smith AW, Han PK, Hays RD, Davis WW, Arora NK, Haffer SC, Clauser SB (2009) Impact of cancer on health-related quality of life of older Americans. J Natl Cancer Inst 101(12):860–868CrossRef
21.
Zurück zum Zitat Jensen GA, Morrisey MA (2004) Are healthier older adults choosing managed care? Gerontologist 44(1):85–94CrossRef Jensen GA, Morrisey MA (2004) Are healthier older adults choosing managed care? Gerontologist 44(1):85–94CrossRef
22.
Zurück zum Zitat Morgan RO, Virnig BA, DeVito CA, Persily NA (1997) The Medicare-HMO revolving door—the healthy go in and the sick go out. N Engl J Med 337(3):169–175CrossRef Morgan RO, Virnig BA, DeVito CA, Persily NA (1997) The Medicare-HMO revolving door—the healthy go in and the sick go out. N Engl J Med 337(3):169–175CrossRef
23.
Zurück zum Zitat Pourat N, Kagawa-Singer M, Wallace SP (2006) Are managed care Medicare beneficiaries with chronic conditions satisfied with their care? J Aging Health 18(1):70–90CrossRef Pourat N, Kagawa-Singer M, Wallace SP (2006) Are managed care Medicare beneficiaries with chronic conditions satisfied with their care? J Aging Health 18(1):70–90CrossRef
24.
Zurück zum Zitat Jagsi R, Abrahamse P, Hawley ST, Graff JJ, Hamilton AS, Katz SJ (2012) Underascertainment of radiotherapy receipt in Surveillance, Epidemiology, and End Results registry data. Cancer 118(2):333–341CrossRef Jagsi R, Abrahamse P, Hawley ST, Graff JJ, Hamilton AS, Katz SJ (2012) Underascertainment of radiotherapy receipt in Surveillance, Epidemiology, and End Results registry data. Cancer 118(2):333–341CrossRef
Metadaten
Titel
Investigating the prognostic ability of health-related quality of life on survival: a prospective cohort study of adults with lung cancer
verfasst von
Laura C. Pinheiro
Bryce B. Reeve
Publikationsdatum
18.05.2018
Verlag
Springer Berlin Heidelberg
Erschienen in
Supportive Care in Cancer / Ausgabe 11/2018
Print ISSN: 0941-4355
Elektronische ISSN: 1433-7339
DOI
https://doi.org/10.1007/s00520-018-4265-3

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