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Breast Cancer Research

Erschienen in:

01.05.2008 | Poster presentation

Investigation into the molecular mechanism of the antiapoptotic functions of CTCF in breast cancer cells using a proteomics approach

verfasst von: CF Méndez-Catalá, I Cherhukhin, F Docquier, D Farrar, E Pugacheva, A Vostrov, E Klenova

Erschienen in: Breast Cancer Research | Sonderheft 2/2008

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Excerpt

CCCTC binding protein (CTCF) is a highly conserved and ubiquitous transcription factor with versatile functions. It is involved in transcriptional regulation, chromatin insulation and epigenetic control [1]. Although CTCF has features of a tumour suppressor gene, it is overexpressed in breast cancer cells; this phenomenon is associated with the resistance of these cells to apoptosis [2]. The aim of the present study is to investigate the molecular mechanisms of the CTCF-dependent resistance of breast cancer cells to apoptosis. …

Klenova EM, Morse HC, Ohlsson R, Lobanenkov VV: The novel BORIS + CTCF gene family is uniquely involved in the epigenetics of normal biology and cancer. Semin Cancer Biol. 2002, 12: 399-414. 10.1016/S1044-579X(02)00060-3.CrossRefPubMed

Docquier F, Farrar D, D'Arcy V, Chernukhin I, Robinson AF, Loukinov D, Vatolin S, Pack S, Mackay A, Harris RA, Dorricott H, O'Hare MJ, Lobanenkov V, Klenova E: Heightened expression of CTCF in breast cancer cells is associated with resistance to apoptosis. Cancer Res. 2005, 65: 5112-5122. 10.1158/0008-5472.CAN-03-3498.CrossRefPubMed

Titel: Investigation into the molecular mechanism of the antiapoptotic functions of CTCF in breast cancer cells using a proteomics approach
verfasst von: CF Méndez-Catalá
I Cherhukhin
F Docquier
D Farrar
E Pugacheva
A Vostrov
E Klenova
Publikationsdatum: 01.05.2008
Verlag: BioMed Central
Erschienen in: Breast Cancer Research / Ausgabe Sonderheft 2/2008
Elektronische ISSN: 1465-542X
DOI: https://doi.org/10.1186/bcr1903

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Springer Medizin

Investigation into the molecular mechanism of the antiapoptotic functions of CTCF in breast cancer cells using a proteomics approach

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