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Erschienen in: Japanese Journal of Radiology 8/2021

15.04.2021 | Original Article

Investigation of MRI-based radiomics model in differentiation between sinonasal primary lymphomas and squamous cell carcinomas

verfasst von: Xinyan Wang, Shuangfeng Dai, Qian Wang, Xiangfei Chai, Junfang Xian

Erschienen in: Japanese Journal of Radiology | Ausgabe 8/2021

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Abstract

Purpose

To develop and validate an MRI-based radiomics model in differentiation between sinonasal primary lymphomas and squamous cell carcinomas (SCCs).

Materials and methods

One-hundred-and-fifty-four patients were enrolled (74 individuals with SCCs and 80 with lymphomas). After feature analysis and feature selection with variance threshold and least absolute shrinkage and selection operator (LASSO) methods, an MRI-based radiomics model with the support vector machine (SVM) classifier was constructed in differentiation between lymphomas and SCCs. Areas under the receiver operating characteristic curves (AUCs) of the MRI-based radiomics model were compared with those of radiologists using Delong test.

Results

Five features (T1 original shape Compactness2, T1 wavelet-HHH first-order Total Energy, T2 wavelet-HLH GLCM Informational Measure of Correlation1, T1 wavelet-LHL GLCM Inverse Variance and T1 square GLRLM Long Run Low Gray Level Emphasis) were finally selected in the radiomics model. The AUC values in differentiation between lymphomas and SCCs were 0.94 for the training dataset and 0.85 for the validation dataset, respectively. For all the patient datasets, the AUC values of radiomics model, readers 1, 2 and 3 were 0.92, 0.76, 0.77 and 0.80, respectively. For the validation datasets, no significant difference was found between the AUCs of the radiomics model and those of the three radiologist (P = 0.459, 0.469, 0.738 for radiologist 1, 2 and 3, respectively).

Conclusion

An MRI-based radiomics model can help to differentiate sinonasal lymphomas from SCCs with high accuracy.
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Metadaten
Titel
Investigation of MRI-based radiomics model in differentiation between sinonasal primary lymphomas and squamous cell carcinomas
verfasst von
Xinyan Wang
Shuangfeng Dai
Qian Wang
Xiangfei Chai
Junfang Xian
Publikationsdatum
15.04.2021
Verlag
Springer Singapore
Erschienen in
Japanese Journal of Radiology / Ausgabe 8/2021
Print ISSN: 1867-1071
Elektronische ISSN: 1867-108X
DOI
https://doi.org/10.1007/s11604-021-01116-6

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