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Erschienen in:
22.09.2021 | Original Article – Cancer Research
Investigation of the roles of IL-18 (-607 C/A) and IL-18 (-137 G/C) gene variations in bladder cancer development: case–control study
Erschienen in: Journal of Cancer Research and Clinical Oncology | Ausgabe 12/2021
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Background
The purpose of our study is to investigate the roles of IL-18 gene variations in bladder cancer development in Thrace population of Turkey.
Methods
This study was carried out with 103 bladder cancer patients and 81 healthy controls. Genotype distributions of IL-18 (-137 G/C) and IL-18 (-607 C/A) gene variations were determined using polymerase chain reaction (PCR) method.
Results
The CC homozygous genotype for IL-18 (-607 C/A) gene variation was significantly higher in patients with bladder cancer compared to healthy controls (OR 0.345, 95% Cl 0.186–0.639, p = 0.001). Besides this, allele frequencies of IL-18 (-137 G/C) and IL-18 (-607 C/A) gene variations in patient with bladder cancer and healthy control groups were significantly different from the Hardy–Weinberg distribution (p < 0.05). For IL-18 (-137 G/C) and IL-18 (-607 C/A) gene variations, significant difference was determined between the bladder cancer patient and healthy control groups in terms of GC–CA (OR 0.381, 95% Cl 0.203–0.714, p = 0.002), GC–CC (OR 2.147, 95% Cl 1.013–4.550, p = 0.043), GG–AA (OR 0.431, 95% Cl 0.365–0.509, p = 0.049), and GG–CC (OR 2.476, 95% Cl 1.177–5.208, p = 0.015) haplotypes.
Conclusion
In our study, CC genotype of IL-18 (-607 C/A) gene variation was determined as genetic risk factor for bladder cancer development. In bladder cancer patient and healthy control groups, G and C allele frequencies of IL-18 (-137 G/C) gene variation, and C and A allele frequencies of IL-18 (-607 C/A) gene variation were determined significantly different from the Hardy–Weinberg distribution.